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BACKGROUND: Horsegram (Dolichos biflorus Linn.) is a known antilithiatic, hypolipedemic and has free radical scavenging activity and increased production of reactive oxygen species play a role in pathophysiological mechanisms that trigger diabetic complications. AIM: To see the effect of daily oral feeding of D.biflorous on nephropathy and retinopathy in streptozotocin (STZ) induced-diabetic rats. MATERIALS AND METHODS: A total of 24 healthy rats were randomly grouped into controls, diabetic and diabetic on Dolichos. Diabetes was induced by a single dose of STZ (55 mg/kg) and animals were given prepared food and water ad libitum. Dolichos was orally given at 300 mg/kg/day to rats in diabetic on Dolichos group for next 30 days. Fasting blood glucose levels was monitored at beginning and at the end of the experiment while assessment of serum creatinine levels and histopathological study of kidney and retina was carried only at the end of the experiment. Statistical differences between groups were analyzed using analysis of variance followed by, Bonferroni test as posthoc test. RESULTS: Results indicated improvement in serum creatinine levels and reduced glomerular sclerosing and Bowman's space with interstitial alterations and significantly reduced renal hypertrophy in diabetic rat son Dolichos diabetic rats (P < 0.001). Retinal layers showed inconsistent improvement in the width of the neuronal layers and decreased vacuolization of plexiform layers and retinal vessel density. CONCLUSION: D. biflorus at doses of 300 mg/kg/day for 30 days resulted in gradual but significant decreased diabetic nephropathy.
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Choroid plexus carcinoma is a very rare tumor in adults. Here we report a rare case of choroid plexus carcinoma in an adult patient. A 24-year-old male presented with a right temporal intraventricular tumor with a cystic component also extending up to the cortex. Histological examination revealed complex papillary structures and glandular spaces showing stratification and multilayering of cells with nuclear crowding and numerous mitotic figures and large areas of necrosis. The patient went through a complete search for a possible primary keeping in mind the differential diagnosis of metastatic carcinoma that is more common in adults but there was no evidence of any other tumor. Finally a diagnosis of choroid plexus carcinoma was rendered. Immunohistochemical analysis for p53 protein showed positivity. Choroid plexus carcinoma is exceptionally rare in adults but cases do occur.
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INTRODUCTION: Hematological malignancies are quite common and affect all ages and genders. The diagnosis involves a multiparameter approach. The geographical distribution of various types of hematological malignancies has been provided by various authors but no such data have been published regarding the State of Uttarakhand in India. AIM: To study the hematological malignancies at Uttarakhand in India based on age, sex and the type of malignancy with further sub typing wherever possible. SETTINGS AND DESIGN: A total of 220 cases of hematological malignancies were worked up from the Reference Laboratory of Himalayan Institute of Medical Sciences over an eight year period (1998-2005). MATERIALS AND METHODS: Diagnosis was mainly based on morphological examination of peripheral blood and bone marrow smears stained by Leishman's stain and MPO, Sudan Black and PAS stain as and where required. Distribution of cases was studied based on age, sex and the type of malignancy with further sub typing wherever possible. RESULTS: The most common hematological malignancy was found to be Leukemia 129/220 (58%) followed b Lymphoma 33/220 (14.8%), Multiple Myeloma 55/220 (24.7%) and Metastatic Lesions 3/220 (1.3%). These malignancies were seen to be distributed throughout all ages with a peak at 11-20 years age group 39/220 (17.5%) and another peak at 51-60 years age group 41/220 (18.4%). We found an overall male preponderance with a M:F ratio of 2.3:1. CONCLUSIONS: The commonest haematological malignancy in our series was Leukemia. Other diagnoses were Multiple Myeloma, Lymphoma and Secondaries. Multiple Myeloma which turned out to be the second most common diagnosis was an unusual finding.
