Assuntos
Clorquinaldol/uso terapêutico , Fármacos Dermatológicos/uso terapêutico , Eczema/tratamento farmacológico , Gramicidina/uso terapêutico , Hidrocortisona/análogos & derivados , Hidroxiquinolinas/uso terapêutico , Neomicina/uso terapêutico , Nistatina/uso terapêutico , Infecções Cutâneas Estafilocócicas/tratamento farmacológico , Triancinolona Acetonida/uso terapêutico , Administração Tópica , Adolescente , Criança , Pré-Escolar , Ensaios Clínicos como Assunto , Método Duplo-Cego , Combinação de Medicamentos/uso terapêutico , Eczema/complicações , Feminino , Humanos , Hidrocortisona/uso terapêutico , Lactente , Masculino , Infecções Cutâneas Estafilocócicas/complicaçõesRESUMO
The use of topical steroids is associated with adverse systemic effects such as suppression of the hypothalamic-pituitary-adrenal (HPA) axis, and application of more than 50 g per week of clobetasol propionate cream has been shown to cause secondary adrenal failure. We describe 4 patients who used clobetasol propionate cream over a prolonged period; 3 patients used less than 50 g per week (7.5, 25 and 30 g per week) and yet all developed secondary adrenal failure for up to 4 months after cessation of therapy. Adrenal insufficiency following prolonged use of clobetasol propionate in moderate dosages may therefore be more common than previously recognized. It is suggested that the metyrapone test, which conveniently examines the entire HPA axis, should be employed in patients receiving long-term topical clobetasol propionate cream and that glucocorticoid supplementation should be given during episodes of stress, such as infections and surgery, for up to 4 months after cessation of therapy.
Assuntos
Glândulas Suprarrenais/efeitos dos fármacos , Betametasona/análogos & derivados , Clobetasol/análogos & derivados , Psoríase/tratamento farmacológico , Administração Tópica , Insuficiência Adrenal/induzido quimicamente , Adulto , Idoso , Clobetasol/administração & dosagem , Clobetasol/efeitos adversos , Clobetasol/uso terapêutico , Depressão Química , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeAssuntos
Pálpebras , Hipersensibilidade/diagnóstico , Adolescente , Criança , Pré-Escolar , Humanos , LactenteRESUMO
The clinical, pathological, and genetic findings in two closely related families in which a number of cases of lipoid proteinosis occurred are described. The necropsy findings, particularly the neuropathological aspects, in a patient who died from a coincidental pancreatic carcinoma are detailed. The genetic aspects are reviewed.
Assuntos
Lipidoses/genética , Proteinose Lipoide de Urbach e Wiethe/genética , Idoso , Encéfalo/patologia , Córtex Cerebral/patologia , Feminino , Hipocampo/patologia , Humanos , Irlanda , Laringe/patologia , Proteinose Lipoide de Urbach e Wiethe/patologia , Masculino , Pessoa de Meia-Idade , Linhagem , Pele/patologiaRESUMO
A case of naevus lipomatosus cutaneous superficialis of Hoffman and Zurhelle (N.L.C.H.Z.) is reported.Naevus lipomatosus cutaneous superficialis is a rare type of naevus first described by Hoffman and Zurhelle (1921). The condition was reviewed by Lynch and Goltz (1958). They noted eight cases in the world literature, and described a ninth. Since then, only a few further cases have been recorded. The most recent report has been from Finley and Musso (1972) who described the first example of this condition in Australia. We report the first case of this unusual condition from Ireland.
