Cardiopulmonary rehabilitation program impact on prognostic markers in selected patients with resting and exercise-induced ventilatory inefficiency: a clinical trial.

[Purpose] Ventilatory limitation is a common problem in patients with chronic heart failure and pulmonary hypertension. Excess ventilation may arise from augmented ventilatory drive, over activity of chemoreceptors and muscle ergoreceptors, or premature onset of lactic acidosis. Exertional dyspnea can cause limitations in the activities of daily living and as a result, reduced quality of life for these patients. The aim of the present study was to evaluate the effect of cardiopulmonary rehabilitation program on ventilatory efficiency for these patients. [Subjects and Methods] Twenty five patients with chronic heart failure and twenty five patients with pulmonary hypertension and only forty of them completed the study. The training program consisted of interval aerobic training program, based on the results of cardiopulmonary exercise testing. Training period was about five months. Outcomes were ventilatory equivalent for CO2, (VE/VCO2 at anaerobic threshold), VO2 at anaerobic threshold, VO2 max and peak work load. Echocardiography parameters were also measured; right ventricular systolic pressure for patients with pulmonary hypertension and ejection fraction for patients with chronic heart failure. [Results] Both groups showed an improvement in ventilation during exercise in favor of patients with pulmonary hypertension. VE/VCO2 decreased by 6.65 in pulmonary hypertension and by 2.9 in chronic heart failure. Right ventricular systolic pressure decreased by 12.05 mmHg in pulmonary hypertension and ejection fraction increased by 17.74% in chronic heart failure. [Conclusion] Physical therapy cardiopulmonary rehabilitation should be considered in managing patients with ventilatory limitation such as pulmonary hypertension and chronic heart failure.

Immunomodulatory effects of two different physical therapy modalities in patients with chronic obstructive pulmonary disease.

[Purpose] Counteracting the systemic cytokine release and its inflammatory effects by improving respiratory muscle strength and controlling lung inflammation may be important for improving immune system in patients with chronic obstructive pulmonary disease, So the aim of the present study was to evaluate the effect of low level laser therapy and inspiratory muscle training on interleukin-6 (IL-6) as a marker of inflammation and CD4+/CD8+ ratio as a marker for T Lymphocytes in these patients. [Subjects and Methods] Forty male patients with stable COPD participated in the study, their ages ranged between 55-65 years. They were randomly divided into group (A) who received inspiratory muscle training and group (B) who received low level laser (LLL) acupuncture stimulation for about 8 week. [Results] There was a reduction in the concentration of plasma IL-6 associated with an increase in CD4+/CD8+ ratio in both groups, but laser was superior to inspiratory muscle training. IL-6 and CD4+/CD8+ were negatively correlated. [Conclusion] Both inspiratory muscle training and low level laser therapy are effective physical therapy modalities in promoting immune disturbances. The results also supported the superior role of LLLT over IMT in managing immune disturbances.