Total adult cardiovascular risk in Central America / Riesgo cardiovascular total en adultos en América América

Objective. To evaluate prevalence of cardiovascular risk among adults 40 years and older using population-based samples from six Central American countries. Methods. Risk factors were derived from a multi-national cross-sectional survey implemented in 2003–2006, which included a sample of 4 202 participants aged 40 years and older. Charts produced by the World Health Organization and the International Society of Hypertension for the Region of the Americas sub-region B were used to predict risk on the basis of factors including age, sex, blood pressure, total serum cholesterol, smoking status, and diabetes status. Results. Overall, 85.9% of the population was classified as having < 10% risk for cardiovascular events during the following ten years. The likelihood of being in this risk group decreased with age in both males and females. Four percent of respondents were identified as having > 20% risk. More than 75% of those with a 30–40% risk had previously been identified by health services, and an additional 23% were identified during the study, suggesting they could be diagnosed by opportunistic screening for diabetes, hypertension and hypercholesterolemia. Results of bivariate analysis showed that respondents who were male, older, obese and/or less educated had higher risk for cardiovascular events, but a multivariate analysis including education indicated highest risks for older, obese, and less educated females. Conclusions. Measuring cardiovascular disease risk identifies most cases of (or at risk for) diabetes, hypertension and hypercholesterolemia among adults 40 years and older. This strategy can facilitate implementation of control programs and decrease disabilities and premature mortality.

Objetivo. Evaluar la prevalencia del riesgo de padecer enfermedades cardiovasculares en adultos de 40 años de edad o mayores mediante el uso de muestras poblacionales obtenidas de seis países de América Central. Métodos. Se tomaron los factores de riesgo de una encuesta transversal multinacional realizada entre 2003 y 2006, que incluyó una muestra de 4 202 participantes de 40 años de edad o mayores. Se usaron gráficos producidos por la Organización Mundial de la Salud y la Sociedad Internacional para la Hipertensión de la Región de las Américas, subregión B, para predecir el riesgo sobre la base de factores como la edad, el sexo, la presión arterial, las concentraciones totales de colesterol sérico, y la situación con respecto al tabaquismo y la diabetes. Resultados. En términos generales, 85,9% de la población quedó clasificada en el grupo con un riesgo menor de 10% de sufrir episodios cardiovasculares en el transcurso de los 10 años siguientes. La probabilidad de pertenecer a este grupo de riesgo disminuyó con la edad, tanto en los hombres como en las mujeres. Se determinó que 4% de los encuestados tenían un riesgo mayor de 20%. Más de 75% de los que tenían un riesgo de 30% a 40% ya habían sido identificados por los servicios de salud y otro 23% fue identificado durante el estudio, lo cual indica que los diagnósticos pueden hacerse mediante un tamizaje oportunista para la detección de diabetes, hipertensión e hipercolesterolemia. Según los resultados del análisis bivariado, los entrevistados de sexo masculino, de edad más avanzada, obesos o con poca escolaridad tenían un mayor riesgo de sufrir episodios cardiovasculares, pero un análisis multivariado que abarcó el nivel educativo reveló que los riesgos más altos los tienen las mujeres mayores, obesas y con poca instrucción. Conclusiones. El cálculo del riesgo cardiovascular permite identificar la mayoría de los casos (o personas con riesgo de presentar) diabetes, hipertensión e hipercolesterolemia en adultos de 40 años de edad o mayores. Esta estrategia puede facilitar la puesta en práctica de los programas de control, así como reducir la discapacidad y la mortalidad prematura.

Total adult cardiovascular risk in Central America / Riesgo cardiovascular total en adultos en América Central

OBJECTIVE:To evaluate prevalence of cardiovascular risk among adults 40 years and older using population-based samples from six Central American countries. METHODS: Risk factors were derived from a multi-national cross-sectional survey implemented in 2003-2006, which included a sample of 4 202 participants aged 40 years and older. Charts produced by the World Health Organization and the International Society of Hypertension for the Region of the Americas sub-region B were used to predict risk on the basis of factors including age, sex, blood pressure, total serum cholesterol, smoking status, and diabetes status. RESULTS: Overall, 85.9% of the population was classified as having < 10% risk for cardiovascular events during the following ten years. The likelihood of being in this risk group decreased with age in both males and females. Four percent of respondents were identified as having > 20% risk. More than 75% of those with a 30-40% risk had previously been identified by health services, and an additional 23% were identified during the study, suggesting they could be diagnosed by opportunistic screening for diabetes, hypertension and hypercholesterolemia. Results of bivariate analysis showed that respondents who were male, older, obese and/or less educated had higher risk for cardiovascular events, but a multivariate analysis including education indicated highest risks for older, obese, and less educated females. CONCLUSIONS: Measuring cardiovascular disease risk identifies most cases of (or at risk for) diabetes, hypertension and hypercholesterolemia among adults 40 years and older. This strategy can facilitate implementation of control programs and decrease disabilities and premature mortality.

RESUMEN OBJETIVO:Evaluar la prevalencia del riesgo de padecer enfermedades cardiovasculares en adultos de 40 años de edad o mayores mediante el uso de muestras poblacionales obtenidas de seis países de América Central. MÉTODOS: Se tomaron los factores de riesgo de una encuesta transversal multinacional realizada entre 2003 y 2006, que incluyó una muestra de 4 202 participantes de 40 años de edad o mayores. Se usaron gráficos producidos por la Organización Mundial de la Salud y la Sociedad Internacional para la Hipertensión de la Región de las Américas, subregión B, para predecir el riesgo sobre la base de factores como la edad, el sexo, la presión arterial, las concentraciones totales de colesterol sérico, y la situación con respecto al tabaquismo y la diabetes. RESULTADOS: En términos generales, 85,9% de la población quedó clasificada en el grupo con un riesgo menor de 10% de sufrir episodios cardiovasculares en el transcurso de los 10 años siguientes. La probabilidad de pertenecer a este grupo de riesgo disminuyó con la edad, tanto en los hombres como en las mujeres. Se determinó que 4% de los encues-tados tenían un riesgo mayor de 20%. Más de 75% de los que tenían un riesgo de 30% a 40% ya habían sido identificados por los servicios de salud y otro 23% fue identificado durante el estudio, lo cual indica que los diagnósticos pueden hacerse mediante un tami-zaje oportunista para la detección de diabetes, hipertensión e hipercolesterolemia. Según los resultados del análisis bivariado, los entrevistados de sexo masculino, de edad más avanzada, obesos o con poca escolaridad tenían un mayor riesgo de sufrir episodios cardiovasculares, pero un análisis multivariado que abarcó el nivel educativo reveló que los riesgos más altos los tienen las mujeres mayores, obesas y con poca instrucción. CONCLUSIONES: El cálculo del riesgo cardiovascular permite identificar la mayoría de los casos (o personas con riesgo de presentar) diabetes, hipertensión e hipercolesterolemia en adultos de 40 años de edad o mayores. Esta estrategia puede facilitar la puesta en práctica de los programas de control, así como reducir la discapacidad y la mortalidad prematura.

Total adult cardiovascular risk in Central America.

OBJECTIVE: To evaluate prevalence of cardiovascular risk among adults 40 years and older using population-based samples from six Central American countries. METHODS: Risk factors were derived from a multi-national cross-sectional survey implemented in 2003-2006, which included a sample of 4 202 participants aged 40 years and older. Charts produced by the World Health Organization and the International Society of Hypertension for the Region of the Americas sub-region B were used to predict risk on the basis of factors including age, sex, blood pressure, total serum cholesterol, smoking status, and diabetes status. RESULTS: Overall, 85.9% of the population was classified as having < 10% risk for cardiovascular events during the following ten years. The likelihood of being in this risk group decreased with age in both males and females. Four percent of respondents were identified as having > 20% risk. More than 75% of those with a 30-40% risk had previously been identified by health services, and an additional 23% were identified during the study, suggesting they could be diagnosed by opportunistic screening for diabetes, hypertension and hypercholesterolemia. Results of bivariate analysis showed that respondents who were male, older, obese and/or less educated had higher risk for cardiovascular events, but a multivariate analysis including education indicated highest risks for older, obese, and less educated females. CONCLUSIONS: Measuring cardiovascular disease risk identifies most cases of (or at risk for) diabetes, hypertension and hypercholesterolemia among adults 40 years and older. This strategy can facilitate implementation of control programs and decrease disabilities and premature mortality.

Prescriçäo de medicamentos para crianças hospitalizadas: como avaliar a qualidade? / Drug prescription for pediatric in patients: how can the quality be evaluated?

Pacientes pediátricos, chamados "órfäos terapêuticos", säo geralmente excluídos de ensaios clínicos para desenvolvimento de novos medicamentos, os quais säo usados em crianças de modo empírico e muitas vezes questionável. Este estudo descreve o padräo de prescriçäo de medicamentos para crianças hospitalizadas e propöe critérios para avaliar a qualidade da prescriçäo. MÉTODOS: O farmacêutico hospitalar determinou a prevalência de prescriçäo de medicamentos em cinco enfermarias pediátricas, a partir da análise conjunta de dados reunidos em quatro coletas de um dia, nos meses de março, abril, maio e junho de 1999, quando foram registrados todos os medicamentos prescritos nas enfermarias em estudo. Foram propostos seis critérios para avaliar a qualidade das prescriçöes. Os medicamentos foram classificados pela ATC, classificaçäo recomendada pela OMS. RESULTADOS: Foi analisada a prescriçäo de 332 pacientes. Os diagnósticos mais freqüentes foram pneumonia (40,4 por cento), meningite e meningococcemia 6 por cento, diarréia e desidrataçäo 6 por cento. As três classes terapêuticas mais prescritas foram: sistema nervoso (N) 109 por cento, antiinfecciosos de uso sistêmico (J) 81,9 por cento e sistema respiratório ( R ) 69 por cento. Os três medicamentos mais prescritos foram dipirona 88,3 por cento, fenoterol 30,7 por cento e penicilina G 25,0 por cento. A avaliaçäo da qualidade, frente aos critérios propostos, mostrou: 1. excessivo uso da via endovenosa, 2. adequada dose dos medicamentos de baixo índice terapêutico, 3. nenhuma duplicaçäo terapêutica, 4. presença de prescriçäo de medicamentos näo aprovados para uso em pediatria ou para indicaçöes näo aprovadas, 5. freqüentes interaçöes medicamentosas potenciais, e 6. prescriçäo de medicamentos näo padronizados pela instituiçäo. CONCLUSÄO: Medidas simples, como o uso mais criterioso da via intravenosa e padronizaçäo adequada às necessidades dos pacientes pediátricos, podem acrescentar qualidade ao atendimento de crianças hospitalizadas e diminuir o seu desconforto. O trabalho mostra o resultado da integraçäo do farmacêutico hospitalar na equipe multiprofissional de saúde

PACE and the Medicare+Choice risk-adjusted payment model.

This paper investigates the impact of the Medicare principal inpatient diagnostic cost group (PIP-DCG) payment model on the Program of All-Inclusive Care for the Elderly (PACE). Currently, more than 6,000 Medicare beneficiaries who are nursing home certifiable receive care from PACE, a program poised for expansion under the Balanced Budget Act of 1997. Overall, our analysis suggests that the application of the PIP-DCG model to the PACE program would reduce Medicare payments to PACE, on average, by 38%. The PIP-DCG payment model bases its risk adjustment on inpatient diagnoses and does not capture adequately the risk of caring for a population with functional impairments.

Partnership insurance. An innovation to meet LTC financing needs.

In the mid-1980s, the Robert Wood Johnson Foundation (RWJF) began to explore ways to support state-based initiatives in long-term care financing. This exploration has resulted in an innovative public-private long-term care insurance program known as the Partnership for Long-Term Care.

[Drug prescription for hospitalized pediatric patients: how can the quality be evaluated?]. / Prescrição de medicamentos para crianças hospitalizadas: como avaliar a qualidade?

BACKGROUND: Pediatric patients called "therapeutic orphans" are usually excluded from clinical trials for development of new drugs, which, sometimes, are used empirically. This study evaluates the prescriptions for pediatric inpatients, and proposes criteria for evaluation of the quality of the prescriptions. METHODS: The hospital pharmacist determined the prevalence of drug prescription in five pediatric wards. One day collection of all prescriptions for pediatric inpatients was performed in March, April, May and June 1999, and the data were jointly analyzed. Six criteria were proposed for quality evaluation of the drug prescriptions. The drugs were classified according to the ATC classification index. RESULTS: The prescriptions of a total of 322 patients were collected in the four collection days. The three most common diagnoses were: pneumonia 40.4%, meningitis and meningococcemia 6%, diarrhea and dehydration 6%. The three most prescribed therapeutic classes were: nervous system (N ) 109%, general antiinfectives for systemic use ( J ) 81.9% and respiratory system ( R ) 69,0%. The three most prescribed drugs were: metamizole 88.3%, fenoterol 30.7% and penicillin G 25.0%. The quality evaluation showed 1. an excessive use of the intravenous route, 2. appropriate dose schedule for drugs with narrow therapeutic index, 3. no therapeutic duplication, 4. prescription of unapproved and off-label drugs, 5. frequent potential adverse drug interactions, and 6. prescription of drugs not in the therapeutic formulary of the hospital. CONCLUSION: Very simple measures can improve the quality of the health care of pediatric inpatients as inclusion of adequate drug presentations in the hospital formulary, and a careful evaluation of the need of the intravenous route. This study also shows the hospital pharmacists acting as part of the multidisciplinary health care team.

Long-term care insurance underwriting: understanding eventual claims experience.

Little is known about the accuracy of medical underwriting for long-term care insurance. The lack of data on claims experience continues to be an obstacle in testing the ability of medical underwriting to identify above average financial risks. This study used actual claims data to simulate medical underwriting and to examine the risk, duration, and timing of nursing home use for people with conditions that are uninsurable. The results show that at least one older person in seven who is rejected for long-term care insurance due to underwriting may not represent greater financial risk to insurers than do those who are accepted.

Pronounced renal vasoconstriction and systemic hypertension in renal transplant patients treated with cyclosporin A versus FK 506.

This prospective study investigated hypertension and renal vasoconstriction developing during the 1st year after renal transplantation in patients randomly allocated to treatment with FK 506 (n = 28) or CyA (n = 13). Starting doses were 0.2-0.3 mg/kg per day for FK 506 and 5-8 mg/kg per day for CyA: doses were subsequently adjusted to trough levels (5-15 ng/ml for FK 506 and 100-150 ng/ml for CyA). We compared 24-h ambulatory blood pressure measurement, antihypertensive treatment, serum creatinine, and resistance index (RI), measured by Doppler ultrasound at the level of the interlobar artery. Until month 2 of treatment, FK 506-treated patients had a significantly lower RI (8%) and better renal graft function, as evidenced by significantly lower serum creatinine values. Some 13% of FK 506-treated patients, compared to 70% of CyA-treated patients (P < 0.01), needed additional antihypertensive drugs after transplantation to keep blood pressure stable. FK 506 treatment, at the above-mentioned dosages, was associated with a significantly higher number of infections (urinary tract infection, pyelonephritis, and pneumonia). We conclude that CyA produces greater renal vasoconstriction and systemic hypertension than FK 506, as reflected in higher renal interlobar artery RI values and a greater need for antihypertensive treatment. After 2 months of treatment and a reduction in CyA trough levels, the renal effects (i.e., lower RI and lower creatinine values), but not the systemic hypertensive effects, disappear.

Transitions in long-term care.

This article examines transitions between the community and nursing homes among the private pay and the Medicaid eligible older (65+) persons. Discrete-time hazard functions were estimated to determine factors associated with the probability of these transitions. The analysis shows that recent hospitalizations for stroke, dementia, or hip fractures, while strongly predictive of nursing home admissions among the Medicaid elderly, were not significant (except for dementia) predictors for the private pay population. The results are of particular relevance in designing long-term care insurance, and more broadly, long-term care policy.

Spending-down to Medicaid in the nursing home and in the community. A longitudinal study from Monroe County, New York.

Medicaid spend-down continues to be of considerable interest in public policy discussions regarding long-term care financing reforms. Yet, "measuring" of spend-down has been difficult because of data limitations. This study focuses on patterns of spend-down affecting those who become Medicaid eligible both in nursing homes and in the community. The study uses a longitudinal, person-specific, merged Medicare and Medicaid claims and eligibility file constructed for Monroe County, New York. The analyses show that 27% of those who enter nursing homes as private pay can be expected to spend-down to Medicaid while in a nursing home. The spend-downers remain in nursing homes for a prolonged time, with 63% staying for more than 3 years. On admission, spend-downers appear somewhat more likely than those who remained private pay or Medicaid throughout to have been less disabled in terms of activities of daily living (ADL). The community-based spend-down group is larger, younger, and more heavily represented by those who are poor or marginally poor, than the nursing home-based spend-down population. Their spend-down to Medicaid appears to have been triggered principally by the cost of acute medical care not covered by Medicare or another third-party payer. It is this population of the elderly that would have been the principal beneficiary of the short-lived 1989 Medicare Catastrophic Coverage Act. The results of this study indicate that neither the existing private long-term care insurance policies nor the currently circulating public coverage proposals alone are sufficient to protect older persons, at risk of spend-down to Medicaid, from impoverishment. Effective long-term care financing reform will need to create partnerships between public and private insurance, rather than look at them as competing options.

Expression of a phosphoenolpyruvate carboxylase promoter from Mesembryanthemum crystallinum is not salt-inducible in mature transgenic tobacco.

The 5' flanking region of a salt-stress-inducible, CAM-specific phosphoenolpyruvate carboxylase (PEPC) gene from the facultative halophyte Mesembryanthemum crystallinum, was fused to the beta-glucuronidase (GUS) reporter gene and introduced into Nicotiana tabacum SR1. The Ppc1 promoter displayed high levels of expression in transgenic tobacco quantitatively and qualitatively similar to a full-length 35S CaMV-GUS construct. Histochemical assays revealed that the full-length Ppc1-GUS fusions expressed GUS activity in all tissues except in root tips. While tobacco is capable of utilizing the Ppc1 cis-acting regulatory regions from M. crystallinum to yield high levels of constitutive expression, this glycophyte fails to direct a stress-inducible pattern of gene expression typical of this promoter in its native, facultative halophytic host.

Paying for long term care without breaking the bank.

As the U.S. population ages and major health care reform looms on the horizon, the search for new sources of financing for long term care has intensified. A key question is whether these resources should come from greater private contributions or from an expansion in public programs. The Partnership for Long Term Care, a new, state-supported public-private program, taps both sectors to protect those in need of chronic, long term care from impoverishment. The Partnership encourages people to plan for their long term care needs and uses Medicaid as reinsurance for those who purchase a certified policy. The four states that are participating in the Partnership have introduced a new form of means testing and better long term care financing options than currently exist.

Asset spend-down in nursing homes. Methods and insights.

The issue of how many elderly are affected by catastrophic nursing home expenses is a major part of the debate over if and/or how to reform long-term-care financing. Currently, there is some discussion regarding the magnitude of this catastrophic event, referred to as "asset spend-down", among the elderly. National data suggest the magnitude is small, while state-specific studies indicate it is greater. In addition, the literature regarding asset spend-down has presented two different measures of its magnitude, further confusing the issue. These two measures, each based on different denominators, have often been presented without adequate explanation. In this study, the authors review both measures and analyze reasons for the differences observed across studies. Major reasons identified include the type of sample used, the mix of payor source at admission, the length of time covered by the data, data on payor source/Medicaid eligibility, and the ability to observe multiple nursing-home stays within the data. Using the measure based on the number of persons who are private pay at admission, these studies indicate that approximately one fourth will eventually deplete assets. The second measure, based on a count of Medicaid residents at a point in time, indicates approximately one third were private pay when admitted. Study results indicate that national studies have underestimated the extent of spend-down due to national-level data limitations, while state-specific studies inevitably refect the specific state data set available and circumstances particular to each state. More state studies and a better understanding of asset transfer are needed.

The use and cost of health services prior to death: a comparison of the Medicare-only and the Medicare-Medicaid elderly populations.

Lack of data has limited research into the high cost and ethical dilemmas associated with care of the dying elderly. This study is based on a five-year, person-specific file of Medicare and Medicaid use and cost data for residents of Monroe County, New York, over the age of 65. It examines and compares utilization and expenditure patterns of the Medicare-only and the Medicare-Medicaid (dually eligible) decedents in 1988. Examination of reimbursement for nonacute services, not covered by Medicare, reveals that services for the "older old" may be less costly immediately prior to death than for younger decedents. However, when expenses in the year prior to the year of death are also counted, services for the dually eligible, older old decedents appear to be neither more nor less costly than for younger decedents. Distribution of expenses does, however, vary considerably with age. The younger decedents, aged 65 to 74, use 55 percent of their medical resources on hospital care, paid for by Medicare; the older old use 26 percent for hospital services and pay 67 percent for supportive care, reimbursed by Medicaid. The study suggests that medical intervention associated with dying is utilized more often and at a higher cost by younger decedents.

Regeneration of multiple shoots and plants from Mesembryanthemum crystallinum.

Mesembryanthemum crystallinum plants have been regenerated via organogenesis from hypocotyl, cotyledonary node, and leaf expiants with varying frequencies. The highest regeneration frequencies were obtained from either hypocotyls (23-34%) or cotyledonary nodes (21-41%). Leaf expiants yielded very poor regeneration frequencies (0-11%). Expiants were placed on Murashige and Skoog (MS) media supplemented with 3% sucrose, 0.8% bacto-agar and either, 10.8×10(-6)M NAA and 8.8×10(-6)M BA (MSmsh), 1×10(-5)M BA and 1×10(-6)M IAA, (MS4) or 1×10(-6)M BA and 1×10(-6)M IAA (MS5). Shoot formation frequencies were greater on MS4 and MS5 and lower on MSmsh, however, overall differences of regeneration frequency among media tested were not statistically significant. Regenerated plantlets were rooted on MS medium without growth regulators. Mature, regenerated plants were fertile and exhibited DNA content and ploidy profiles that were identical to wild type plants.