Observing the universal screening of a Kondo impurity.

The Kondo effect, deriving from a local magnetic impurity mediating electron-electron interactions, constitutes a flourishing basis for understanding a large variety of intricate many-body problems. Its experimental implementation in tunable circuits has made possible important advances through well-controlled investigations. However, these have mostly concerned transport properties, whereas thermodynamic observations - notably the fundamental measurement of the spin of the Kondo impurity - remain elusive in test-bed circuits. Here, with a novel combination of a 'charge' Kondo circuit with a charge sensor, we directly observe the state of the impurity and its progressive screening. We establish the universal renormalization flow from a single free spin to a screened singlet, the associated reduction in the magnetization, and the relationship between scaling Kondo temperature and microscopic parameters. In our device, a Kondo pseudospin is realized by two degenerate charge states of a metallic island, which we measure with a non-invasive, capacitively coupled charge sensor. Such pseudospin probe of an engineered Kondo system opens the way to the thermodynamic investigation of many exotic quantum states, including the clear observation of Majorana zero modes through their fractional entropy.

Broadband electro-optic polarization conversion with atomically thin black phosphorus.

Active polarization control is highly desirable in photonic systems but has been limited mostly to discrete structures in bulky dielectric media and liquid crystal­based variable retarders. Here, we report electrically reconfigurable polarization conversion across telecommunication wavelengths (1410 to 1575 nanometers) in van der Waals layered materials using tri-layer black phosphorus (TLBP) integrated in a Fabry-Pérot cavity. The large electrical tunability of birefringence in TLBP enables spectrally broadband polarization control. We found that polarization states could be generated over a large fraction of the Poincaré sphere through spectral tuning, and that electrical tuning enables the state of polarization conversion to span nearly half the Poincaré sphere. We observed both linear to circular and cross-polarization conversion with voltage, demonstrating versatility with a high dynamic range.

Tunable intraband optical conductivity and polarization-dependent epsilon-near-zero behavior in black phosphorus.

Black phosphorus (BP) offers considerable promise for infrared and visible photonics. Efficient tuning of the bandgap and higher subbands in BP by modulation of the Fermi level or application of vertical electric fields has been previously demonstrated, allowing electrical control of its above-bandgap optical properties. Here, we report modulation of the optical conductivity below the bandgap (5 to 15 µm) by tuning the charge density in a two-dimensional electron gas induced in BP, thereby modifying its free carrier-dominated intraband response. With a moderate doping density of 7 × 1012 cm-2, we were able to observe a polarization-dependent epsilon-near-zero behavior in the dielectric permittivity of BP. The intraband polarization sensitivity is intimately linked to the difference in effective fermionic masses along the two crystallographic directions, as confirmed by our measurements. Our results suggest the potential of multilayer BP to allow new optical functions for emerging photonics applications.

Dynamic cooling strategy based on individual animal response mitigated heat stress in dairy cows.

Technological progress enables individual cow's temperatures to be measured in real time, using a bolus sensor inserted into the rumen (reticulorumen). However, current cooling systems often work at a constant schedule based on the ambient temperature and not on monitoring the animal itself. This study hypothesized that tailoring the cooling management to the cow's thermal reaction can mitigate heat stress. We propose a dynamic cooling system based on in vivo temperature sensors (boluses). Thus, cooling can be activated as needed and is thus most efficacious. A total of 30 lactating cows were randomly assigned to one of two groups; the groups received two different evaporative cooling regimes. A control group received cooling sessions on a preset time-based schedule, the method commonly used in farms; and an experimental group, which received the sensor-based (SB) cooling regime. Sensor-based was changed weekly according to the cow's reaction, as reflected in the changes in body temperatures from the previous week, as measured by reticulorumen boluses. The two treatment groups of cows had similar milk yields (44.7 kg/d), but those in the experimental group had higher milk fat (3.65 vs 3.43%), higher milk protein (3.23 vs 3.13%), higher energy corrected milk (ECM, 42.84 vs 41.48 kg/d), higher fat corrected milk 4%; (42.76 vs 41.34 kg/d), and shorter heat stress duration (5.03 vs 9.46 h/day) comparing to the control. Dry matter intake was higher in the experimental group. Daily visits to the feed trough were less frequent, with each visit lasting longer. The sensor-based cooling regime may be an effective tool to detect and ease heat stress in high-producing dairy cows during transitional seasons when heat load can become severe in arid and semi-arid zones.

Effect of forage-to-concentrate ratio on production efficiency of low-efficient high-yielding lactating cows.

Feed is usually the costliest input in lactating cow's farms. Therefore, the developing of methods for a better adjustment of feed intake to cow's energetic needs in order to improve efficiency is desired. The aim of this study was to improve feed efficiency of low-efficient (LE) cows through a moderate increase in diet forage-to-concentrate ratio. We studied the effects of replacing 8.2% corn grains in a control low-fiber (LF) diet that contained 17.5% forage neutral detergent fiber (NDF) with 7.5% wheat straw +0.7% soybean meal for a high-fiber (HF) diet that contained 23.4% forage NDF. Based on efficiency data of individual cows from the Agricultural Research Organization's herd measured in our previous study, 15 pairs of pre-classified LE multiparous mid-lactating Israeli Holstein dairy cows were selected, each pair with similar performance, intake, and efficiency data; each member of a pair was then adapted for 2 weeks to one or the other dietary treatment. Traits examined during the 5 weeks of the experiment were DM intake (DMI), eating behavior, milk production, in vivo digestibility, and estimation of feed efficiency [energy-corrected milk (ECM)/DMI and energy balance]. Cows fed the HF diet showed slower eating rate, smaller visit and meal sizes, longer daily eating time, higher visit frequency, and longer meal duration, compared to those fed the LF diet. The DMI of cows fed the HF diet was 9.1% lower, their DM digestibility decreased from 65.7 to 62.2%, and their ECM yield was 7.0% lower than in cows fed the LF diet. Feed efficiency, measured as net energy captured/digestible energy intake, improved in the cows fed the HF vs. LF diet while feed efficiency measured as ECM/DMI remained similar. Our results thus show the potential of improving feed efficiency for milk production in LE cows by increasing the forage-to-concentrate ratio.

Dietary restriction improved feed efficiency of inefficient lactating cows.

The aim of this study was to reduce voluntary dry matter intake (DMI) to increase feeding efficiency of preclassified inefficient (INE) dairy cows through restricted feeding. We studied the effects of dietary restriction on eating behavior, milk and energy-corrected milk (ECM) production, in vivo digestibility, energy balance, and measures of feed efficiency [residual feed intake (RFI) and ECM/DMI]. Before the experiment, 12 pairs of cows were classified as INE. The 2 dietary treatments consisted of ad libitum feeding versus restricted feeding of the same total mixed ration containing 36.5% roughage. Inefficient cows fed the restricted total mixed ration had a shorter eating time and lower meal and visit frequency, but a similar rate of eating, meal size, and meal duration compared with INE cows fed ad libitum. Compared with the INE cows fed ad libitum, restricted INE cows had 12.8% lower intake, their dry matter and neutral detergent fiber digestibility remained similar, and their ECM yield was 5.3% lower. Feed efficiency, measured as RFI, ECM/DMI, and net energy retained divided by digestible energy intake, was improved in the restricted INE cows as compared with the ad libitum cows. Our results show that moderate DMI restriction has the potential to improve feed efficiency of preclassified INE cows.

Effect of lactation trimester and parity on eating behavior, milk production and efficiency traits of dairy cows.

There is absence knowledge about the effects of lactation trimester and parity on eating behavior, production and efficiency of dairy cows. Objective of this study was to identify and characterize in 340 dairy cows, the 20% high efficient (HE), 20% low efficient (LE) and 60% mid efficient (ME) cows according to their individual residual feed intake (RFI) values, within and between lactation trimesters and between 1st and 2nd parities. Efficiency effect within each lactation trimester, was exhibited in daily dry matter intake (DMI), eating rate and meal size, that were the highest in LE cows, moderate in the ME cows and lowest in the HE group. Daily eating time, meal frequency, yields of milk and energy-corrected milk (ECM) and BW were similar in the three efficiency groups within each trimester. The lower efficiency of the LE cows in each trimester attributes to their larger metabolic energy intake, heat production and energy losses. In subgroup of 52 multiparous cows examined along their 1st and 2nd trimesters, milk and ECM production, DMI, eating behavior and efficiency traits were similar with high Pearson's correlation (r=0.78 to 0.89) between trimesters. In another subgroup of 42 multiparous cows measured at their 2nd and 3rd trimesters, milk and ECM yield, DMI and eating time were reduced (P<0.01) at the 3rd trimester, but eating rate, meal frequency and meal size remained similar with high Pearson's correlation (r=0.74 to 0.88) between trimesters. In subgroup of 26 cows measured in 1st and 2nd parities, DMI, BW, milk and ECM yield, and ECM/DMI increased in the 2nd lactation, but eating behavior and RFI traits were similar in both parities. These findings encourage accurate prediction of DMI based on a model that includes eating behavior parameters, together with individual measurement of ECM production. This can be further used to identify HE cows in commercial herd, a step necessary for potential genetic selection program aimed to improve herd efficiency.

Eating behavior, milk production, rumination, and digestibility characteristics of high- and low-efficiency lactating cows fed a low-roughage diet.

This study aimed to identify individual characteristics differing among high-efficiency (HEf; upper 20%, n = 31), low-efficiency (LEf; lower 20%, n = 31), and mid-efficiency (MEf, 60% n = 93) lactating cows. Primiparous (37) and multiparous (118) high-producing milking cows at 30 to 180 d in milk were fed individually a low-roughage diet [31.6% of dry matter (DM)] for 4 wk. Daily average DM intake, rate of eating, visit duration, meal size, and daily rumination time were higher in LEf compared with HEf cows. On the other hand, HEf cows exhibited higher digestibility of DM, crude protein, and neutral detergent fiber than the LEf cows. Daily eating time was similar in the HEf and LEf groups and higher than that of the MEf cows. Visit and meal frequency, average visit and meal duration, daily lying time, and pedometer activity were similar in the HEf, LEf, and MEf groups. The HEf cows produced 1.75% more milk, but similar energy-corrected milk compared with the LEf cows. Milk fat and protein content were lower by 1.8 and 3.8%, respectively, in the HEf cows than in the LEf group. Body weight (BW) and BW gain were similar in the 3 efficiency groups. Diurnal distribution of DM intake showed 6 distinct major meals, each composed of 1.1 to 1.6 visits. Higher intake peaks (greater meal size) were found in the LEf cows compared with the HEf group. Daily DM intake was highly correlated (affected) with energy-corrected milk production (r = 0.61), BW (r = 0.4), eating rate (r = 0.57), and visit size (r = 0.54). Energy balance showed that the lower efficiency of the LEf cows was attributed to their excess heat production and energy loss.

Effect of feeding long or short wheat hay v. wheat silage in the ration of lactating cows on intake, milk production and digestibility.

The objective of this study was to evaluate in lactating cows the effect of either chopping or ensiling of wheat roughage on: intake, digestibility, lactation performance and animal behavior. Three groups of 14 lactating cows each, were fed total mixed rations (TMRs) based on either long wheat hay (HL), short wheat hay (HS) or wheat silage (SI), as the sole roughage source (30% of TMR dry matter (DM)). Parameters examined: sorting behavior, DM intake, milk yield and composition, rumination, recumbence, average daily rumen pH, digesta passage rate, and in-vivo digestibility. Performance data was summarized by day and analyzed using a proc-mixed model. The content of physically effective neutral detergent fiber (peNDF) was similar in the HL and SI and lower in the HS, resulting in similar differences among the three corresponding TMRs. In vitro DM digestibility of wheat silage was higher than that of the two hays (65.6% v. 62.8%) resulting in higher in vitro DM digestibility of the SI-TMR compared with the hay-based TMRs (79.3 v. 77.0%). HS-TMR was better than HL- or SI-TMRs at preventing feed sorting by cows after 12 or 24 h eating of the diets. Cows fed HS-TMR consumed more DM and NDF but less peNDF than the other two groups. Average daily rumen pH was similar in the three groups, but daily rumination time was highest in the cows fed HS-TMR. Rumen retention time was longest in cows fed HL-TMR. DM digestibility in cows fed SI-TMR was higher than that of HS and HL groups (65.2%, 61.8% and 62.4%, respectively), but NDF digestibility was similar in the three treatments. The highest intake of digestible DM was observed in cows fed SI-TMR, HS cows were intermediate and HL cows were the lowest. Consequently, cows fed SI-TMR had higher yields of milk, 4% fat corrected milk and energy-corrected milk (47.1, 42.9 and 43.2 kg/day, respectively) than cows fed HS-TMR (45.7, 41.0 and 41.0 kg/day, respectively) or HL-TMR (44.1, 40.3 and 40.3 kg/day, respectively). Net energy production (NEL+M+gain) per kg DM intake was highest in the SI-TMR, lowest in the HS-TMR and intermediate in the HL-TMR (1.52, 1.40 and 1.45, respectively). Animal welfare, as expressed in daily recumbence time and BW gain was similar in the SI and HS groups and higher than the HL cows.

[The influence of military underwater activity on the oral cavity].

The military dentists who serve in the navy, treat divers, among other patients. Divers are being exposed to a changing, unique environment on a regular basis. The aim of this article is to review latest literature on the different effects of scuba diving on the diver's head, face and oral regions and to emphasize methods of disease prevention, diagnostic tools and treatment guidelines. The review focuses on diving barotrauma (pressure- induced injury related to an air space) as well as scuba diving mouthpiece-related oral conditions, which include facial, jaw pain and headaches, decompression sickness and mouthpiece-related herpes infection. Each condition is described by its effect on the oral cavity and in particular the teeth.

Effect of wheat hay particle size and replacement of wheat hay with wheat silage on rumen pH, rumination and digestibility in ruminally cannulated non-lactating cows.

This study examined the effects on intake, diurnal rumen pH changes, rumination and digestibility of feeding ruminally cannulated non-lactating cows in a Latin square design (four cows×four periods) with four total mixed rations (TMRs) typical for lactating cows. TMRs were based on: long wheat hay or short wheat hay, wheat silage or wheat silage+1.5% NaHCO3 buffer, as the sole roughage source (30% of TMR dry matter (DM)). The level of physically effective NDF remaining above the 8 mm screen (peNDF) was similar in the long hay and silage-based TMRs (9.45% to 9.64% of DM) and lower in the short hay TMR (7.47% of DM). The four TMRs were offered individually at 95% of ad libitum intake to avoid orts within 24 h. Cows fed long hay consumed less DM than the short hay and silage groups (9.6 v. 10.5 and 10.8 kg/day, respectively) and sorted against large hay particles at 12 h post-feeding. Under the limitations of this study (non-lactating cows fed at restricted intake) short hay TMR prevented sorting within 12 h post-feeding, encouraged rumination per kg peNDF ingested, and had higher average rumen pH (6.24), whereas preventing sub acute ruminal acidosis (SARA, defined as pH<5.8 for at least 5 h/day). In contrast, the long hay and silage-based groups were under SARA. In vitro methane production of rumen fluid was higher in the hay-fed cows than in their silage-fed counterparts, and in all treatments lower at 1 h pre-feeding than at 6 h post-feeding. In vivo DM and NDF digestibility were similar for the short hay and silage TMRs, and higher than those of the long hay TMR. Under the conditions of this study, addition of 1.5% buffer to the wheat silage TMR had no effect on intake, rumen pH, creation of SARA and digestibility.

Feeding behavior improves prediction of dairy cow voluntary feed intake but cannot serve as the sole indicator.

Low-cost feeding-behavior sensors will soon be available for commercial use in dairy farms. The aim of this study was to develop a feed intake model for the individual dairy cow that includes feeding behavior. In a research farm, the individual cows' voluntary feed intake and feeding behavior were monitored at every meal. A feed intake model was developed based on data that exist in commercial modern farms: 'BW,' 'milk yield' and 'days in milking' parameters were applied in this study. At the individual cow level, eating velocity seemed to be correlated with feed intake (R 2=0.93 to 0.94). The eating velocity coefficient varied among individuals, ranging from 150 to 230 g/min per cow. The contribution of feeding behavior (0.28) to the dry matter intake (DMI) model was higher than the contribution of BW (0.20), similar to the contribution of fat-corrected milk (FCM)/BW (0.29) and not as large as the contribution of FCM (0.49). Incorporating feeding behavior into the DMI model improved its accuracy by 1.3 (38%) kg/cow per day. The model is ready to be implemented in commercial farms as soon as companies introduce low-cost feeding-behavior sensors on commercial level.

Nonstationary regimes of homogeneous Hamiltonian systems in the state of sonic vacuum.

In the present paper we study the mechanism that leads to the formation of regular patterns of energy localization and complete recurrent energy transport in the homogeneous systems of anharmonic oscillators and oscillatory chains subjected to a state of sonic vacuum. The basic model under investigation comprises a system of purely anharmonic oscillators as well as oscillatory chains given to a localized excitation where the initial energy is imported to one of the oscillators or oscillatory chains. The results of numerical simulations reveal the existence of a strong classical beating phenomenon, characterized by complete, recurrent, resonant energy exchanges between the oscillators and oscillatory chain and this in the state of sonic vacuum where no regular resonant frequencies can be defined. In this study we show that formation of the recurrent energy exchanges in this highly degenerate model is strictly stipulated by the system parameters. Thus, for instance, choosing the parameter of coupling below a certain threshold leads to significant energy localization on one of the oscillators or oscillatory chains. However, increasing the strength of coupling above the threshold leads to the formation of a strong beating response. The analytical study pursued in this paper predicts the origin of formation of a strong beating phenomenon and provides the necessary conditions on the system parameter for its excitation. Moreover, careful analysis of the beating phenomenon reveals the qualitatively different global bifurcation undergone by this type of highly nonstationary regime. The theoretical study is further extended to the system of coupled purely anharmonic lattices. Thus we show analytically and numerically that excitation of some particular solutions (e.g., spatially periodic standing waves and standing breathers) on one of the lattices results in the formation of similar patterns of energy (wave) localization as well as the regime of complete recurrent interchain energy transport. In particular we demonstrate that the formation of these regimes is solely affected by a particular choice of system parameters. The results of the analytical study are found to be in very good agreement with those of numerical simulations.

A magnetically focused molecular beam of ortho-water.

Like dihydrogen, water exists as two spin isomers, ortho and para, with the nuclear magnetic moments of the hydrogen atoms either parallel or antiparallel. The ratio of the two spin isomers and their physical properties play an important role in a wide variety of research fields, ranging from astrophysics to nuclear magnetic resonance (NMR). Unlike ortho and para H(2), however, the two water isomers remain challenging to separate, and as a consequence, very little is currently known about their different physical properties. Here, we report the formation of a magnetically focused molecular beam of ortho-water. The beam we formed also had a particular spin projection. Thus, in the presence of holding magnetic fields, the water molecules are hyperpolarized, laying the foundation for ultrasensitive NMR experiments in the future.

Probing the Kondo density of states in a three-terminal quantum ring.

We have measured the Kondo effect in a quantum ring connected to three terminals. In this configuration nonlinear transport measurements allow us to check which lead contributes to the Kondo density of states (DOS) and which does not. The ring geometry allows a fine-tuning of the coupling to each lead through the Aharonov-Bohm effect via application of a magnetic field. When the ring is connected to two strongly and one weakly coupled leads, conductance through the weakly coupled lead provides a direct measurement of the DOS in the Kondo regime. By applying a bias between the two strongly coupled leads, we demonstrate directly the splitting of the out-of-equilibrium Kondo DOS.

Does cervical length at 13-15 weeks' gestation predict preterm delivery in an unselected population?

OBJECTIVE: To assess the role of early mid-trimester cervical length measurement as a predictor of spontaneous preterm birth in an unselected population. METHODS: In this prospective study, unselected, asymptomatic, Caucasian women with singleton pregnancies underwent standardized transvaginal ultrasonographic (TVS) cervical length measurement at 13-15 weeks' gestation as a screening test for preterm delivery (PTD). Women with multiple gestations, iatrogenic PTD, and previous cervical conization were excluded. The primary outcome measures were spontaneous PTD at < 37 and < 34 weeks. The correlation between cervical length and previous obstetric history was evaluated. RESULTS: A total of 2469 patients met the inclusion criteria. The mean gestational age at cervical assessment was 14 + 2 weeks. The mean gestational age at delivery was 40 + 0 weeks. The rate of spontaneous deliveries before 37 weeks' gestation was 1.7%. In 0.2% the delivery occurred before 34 weeks' gestation. The mean +/- standard deviation cervical length for the entire population was 44.2 +/- 5.4 mm. No difference was observed between cervical length in women that delivered at term and those that delivered either before 37 or before 34 weeks' gestation. Previous obstetric history (prior preterm birth, previous miscarriages and terminations, and parity) did not affect cervical length at 14 weeks of gestation. CONCLUSIONS: Performed at 14 weeks' gestation, TVS measurement of the cervical canal length to predict spontaneous PTD is not a reliable screening procedure.

Does amniotic fluid alpha-fetoprotein have diagnostic or prognostic value at the time of second midtrimester genetic amniocentesis?

In order to assess the usefulness of amniotic fluid alpha-fetoprotein (AFP) levels at the time of midtrimester genetic amniocentesis, 4,430 cases were retrospectively studied to compare the high, normal or low AFP values with the karyotype characteristics and fetal anatomy using ultrasound (US) scanning and confirmed by postnatal evaluation or necroscopy in the case of termination of pregnancy. All the cases presenting malformations were correctly diagnosed by US examinations. AFP levels over the 2nd standard deviation (SD) were found in 112 cases (2.52%) and below the 2nd SD in 11 cases (0.24%). The characteristics of these cases are presented and discussed. According to our results, it is concluded that routine assessment of AFP at the time of midtrimester genetic amniocentesis, if coupled with optimal US scanning, is no longer justified.

Antepartal assessment of IUGR fetuses.

Intrauterine growth restriction (IUGR) should be defined on the basis of a prenatally recognized defective growth compared to that expected for this fetus. This condition is encountered in 10-15% of the pregnancies and the perinatal outcome is impaired mainly as a consequence of fetal hypoxemia that is present in 30% of IUGR fetuses. In order to allow for proper management, the IUGR should be recognized prenatally and the method of choice for this purpose is ultrasound fetal biometry. After the identification of IUGR, 2nd level tests should be performed in order to assess the fetal oxygenation conditions. The validity of Doppler investigation on fetal and umbilical vessels is discussed, and the importance of using computer assisted cardiotocography instead of traditional eye ball evaluation of the non-stress test is emphasized.

Early screening for fetal cardiac anomalies by transvaginal echocardiography in an unselected population: the role of operator experience.

OBJECTIVES: To examine the accuracy of early transvaginal fetal echocardiography performed in an unselected population by operators with different levels of experience and to compare the results with those obtained from a referral population. DESIGN: Prospective study. METHODS: A series of 4785 unselected fetuses and 221 referred fetuses were screened at 13-15 weeks' gestational age by transvaginal echocardiography. For each fetus, visualization of the four-chamber view plus the origin of the great arteries was attempted. Color Doppler imaging was only performed in cases of cardiac malformations already identified by two-dimensional echocardiography. The scans were performed by seven operators with different levels of experience. Reliability was assessed by conventional transabdominal echocardiography at 20-22 weeks, by postnatal follow-up in the first 3 months of life, and/or by autopsy in all cases of termination or fetal death. RESULTS: The rate of complete visualization (four-chamber view plus great arteries) was 47.5% in the unselected population, and 76.9% in the referral population. There were four (0.08%) true positives among the unselected fetuses, and five (2.3%) among referrals, mostly with enlarged nuchal translucency or other malformations. Among the unselected fetuses, nine false negatives were detected by transabdominal echocardiography. Improvement in the operators' ability to recognize cardiac anomalies in unselected population was disappointing and was influenced more by individual approach than by the number of examinations performed. CONCLUSIONS: Early screening for cardiac anomalies among unselected fetuses is ill-advisable. The usefulness of an early approach is confirmed in high risk fetuses or in the presence of enlarged nuchal translucency when performed by expert operators.