1.
Chemistry
; 23(21): 5137-5142, 2017 Apr 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28165173
RESUMO
A highly enantio- and diastereoselective [4+1] annulation between in situ generated ammonium ylides and o-quinone methides for the synthesis of a variety of 2,3-dihydrobenzofurans has been developed. The key factors controlling the reactivity and stereoselectivity were systematically investigated by experimental and computational means and the energy profiles obtained provide a deeper insight into the mechanistic details of this reaction.