Resultados visuales de implante de lente trifocal en pacientes con glaucoma / Visual outcomes with trifocal lens implant in glaucoma patients

Objetivo: Evaluar los resultados visuales en pacientes con sospecha de glaucoma y glaucoma leve candidatos a cirugía de catarata e implante de lente intraocular trifocal. Diseño del estudio: Estudio longitudinal, prospectivo, experimental y analítico. Métodos: Se incluyeron pacientes con catarata y diagnóstico de glaucoma leve o sospechoso de glaucoma que contaran con campo visual, tomografía de nervio óptico y estudio de sensibilidad al contraste y se les realizo cirugía de catarata por facoemulsificación del cristalino con implante de lente intraocular trifocal AT LISA tri 839 MP. Resultados: Se incluyeron 9 ojos de 5 pacientes (4 mujeres y 1 hombre) entre los 66 y 87 años con un promedio de 73.2 ± 7.6 años. La agudeza visual prequirúrgica con corrección lejana fue de 0.29±0.16 LogMar (20/40), intermedia 0.67±0.49 LogMar (20/60), cercana 0.66± 0.57 LogMar (20/80); al mes postquirúrgico la agudeza visual con corrección lejana fue 0.08± 0.06 LogMar (20/25), intermedia 0.05± 0.06 LogMar (20/20), cercana 0.02±0.03 LogMar (20/20). Encontramos una mejoría estadísticamente significativa de la agudeza visual al mes de postoperatorio. En el análisis de la sensibilidad al contraste prequirúrgica y postquirúrgica, no observamos diferencias estadísticamente significativas en ninguna de las frecuencias espaciales (3cpg 1.32 ± 0.25 vs 1.34 ± 0.26, 6cpg 1.41 ± 0.30 vs 1.46 ± 0.28, 12 cpg 1.094 ± 0.42 vs 0.98 ± 0.37, 18cpg 0.69 ± 0.41 vs 0.60 ± 0.30). Conclusiones: Los resultados visuales obtenidos a diferentes distancias con el diseño trifocal indican que esta técnica emergente constituye una alternativa para la cirugía de catarata para pacientes candidatos con glaucoma leve o sospecha de glaucoma sin que el procedimiento altere su seguimiento ni modifique la sensibilidad al contraste.

Objective: To evaluate visual results in patients with glaucoma suspect and mild glaucoma, candidates for cataract surgery and trifocal intraocular lens implantation. Study design: Longitudinal, prospective, experimental and analytical study. Methods: We include patients with cataract and diagnosis of mild or glaucoma suspect who had a visual field, optic nerve tomography and contrast sensitivity study. They underwent to cataract surgery with trifocal intraocular lens implant (ATLISAtri839MP). Results: 9 eyes of 5 patients (4 women and 1 man) were included between 66 and 87 years, with an average of 73.2 ± 7.6 years. Preoperative visual acuity with distance correction was 0.29 ± 0.16 LogMar (20/40), intermediate 0.67 ± 0.49 LogMar (20/60), near to 0.66 ± 0.57 LogMar (20/80); the results per month were: the visual acuity with distance correction was 0.08 ± 0.06 LogMar (20/25), intermediate 0.05 ± 0.06 LogMar (20/20), near to 0.02 ± 0.03 LogMar (20/20). We found improvement in visual acuity at the month of postoperative, statistically significant. In the analysis of preoperative and postsurgical contrast sensitivity, we did not observe statistically signifi cant differences in any of the spatial frequencies (3cpg 1.32 ± 0.25 vs 1.34 ± 0.26, 6cpg 1.41 ± 0.30 vs 1.46 ± 0.28, 12 cpg 1.094 ± 0.42 vs 0.98 ± 0.37, 18 cpg 0.69 ± 0.41 vs. 0.60 ± 0.30). Conclusions: The visual results obtained at different distances with the trifocal design indicate that this emerging technique is an alternative for cataract surgery for candidates with mild glaucoma or glaucoma suspect; whereas the procedure does not alter follow-up or contrast sensitivity.

Spatio-temporal distribution of microglia/macrophages during regeneration in the cerebellum of adult teleost fish, Apteronotus leptorhynchus: a quantitative analysis.

In contrast to mammals, adult teleost fish exhibit an enormous capacity to replace damaged neurons with newly generated ones after injuries in the central nervous system. In the present study, the role of microglia/macrophages, identified by tomato lectin binding, was examined in this process of neuronal regeneration in the corpus cerebelli of the teleost fish Apteronotus leptorhynchus. In the intact corpus cerebelli, or after short survival times following application of a mechanical lesion to this cerebellar subdivision, microglia/macrophages were virtually absent. Conversely, approximately 3 days after application of the lesion, the areal density of microglia/macrophages started to increase at and near the lesion site in the ipsilateral hemisphere, as well as in the contralateral hemisphere, and reached maximum levels at approximately 10 days post lesion. The density remained elevated until it reached background levels approximately one month after the injury. By comparing the time course of the appearance of microglia/macrophages with that of other regenerative events occurring within the first few weeks of wound healing in this model system, we hypothesize that one possible function of microglia/macrophages might be to remove debris of cells that have undergone apoptotic cell death at the lesion site.