[Quantitative analysis of the changes in the nuclear apparatus of thyrocytes in experimental thyroid hyperfunction]. / Kolichestvennyi analiz izmenenii iadernogo apparata tireotsitov pri éksperimental'noi giperfunktsii shchitovidnoi zhelezy.

Quantitative ultrastructural characteristics (volume, surface area, volume fraction and surface density) of the nucleus, nucleolus and cell were studied in albino rats after long-term (5, 10, 15, 20 days) melanotropin (MSH) administration. The experiments showed that enhanced functional activity of thyroid cells induced by MSH administration was accompanied by an increase in the volume, surface area of the nucleus, nucleolus and the cell proper, as well as by an increased nuclear pore diameter. Consequently, the nucleus-cytoplasm ratio in thyroid cells rises.

[Evolution of the adaptive functions of hypophyseal hormones detected by using hypothalamic melanostatin]. / Evoliutsiia adaptivnykh funktsii nekotorykh gipofizarnykh gormonov, vyiavlennaia s pomoshch'iu gipotalamicheskogo melanostatina.

The content of two pituitary tropins (MSH and ACTH) has been determined in rats which were injected by the synthetic melanostatin to suppress MSH of the intermediate part of pituitary by radioimmune analysis. Besides, the function of the adrenal cortex according the content of corticosterone in various tissues was estimated. It has been revealed that the pituitary-adrenal complex activation is caused by the hypothalamic melanostatin suppression of the MSH secretion. All these testify the ACTH and MSH definite role in organisms adaptive reactions at different evolution steps.

[Functional state of the sympathetic-adrenal system in melanocyte-stimulating hormone deficiency under the effect of the melanocyte-inhibiting factor of the hypothalamus]. / Funktsional'noe sostoianie simpatiko-adrenalovoi sistemy pri defitsite melanotsitstimuliruiushchego gormona gipofiza pod vliianiem melanotsitingibiruiushchego faktora gipotalamusa.

Fluorometry was applied to the study of the content of a number of amines (DOPA), adrenalin, noradrenaline) in the adrenal glands and various structures of the rat brain in endogenous deficiency of melanocyte-stimulating hormone of the hypophysis caused by parenteral administration of synthetic melanostatin (MIF) of the hypothalamus. The amines content in the adrenal glands medulla, and also in the medulla oblongata; the cerebellum, and the large hemispheres proved to change 30 to 60 min after MIF administration. The results obtained indicated that various links of the sympathico-adrenal system could take part in the mechanism of MIF action on the hypophysis.

[Electrophoretic determination of quantitative changes of the blood protein fractions after intermedin administration]. / Elektroforeticheskoe opredelenie kolichestvennykh izmenenii belkovykh fraktsii krovi pri vvedenii intermedina.

The authors present the results of experimental studies of the blood serum proteins metabolism in prolonged administration of intermedin--a hormone of the intermediate lobe of the hypophysis. Daily administration of this hormone caused a reduction of albumins and an increase of the beta-globulin fraction. The most pronounced changes in the protein spectrum were noted on the 15th-20th day of the experiment.

[Changes in the thyrocytes to the administration of intermedin under conditions of the aminazine-altered functional state of the nervous system]. / Izmeneniia tireotsitov pri vvedenii intermedina v usloviiakh izmenennogo aminazinom funktsional'nogo sostoianiia nervoi sistemy

Histological and electron microscopial investigations of the thyroid gland were performed in white mice after exogeneous administration of intermedin (MSH) and intermedin against the background of aminasin. It may be concluded that while a prolonged injection of MSH results in the stimulation of the thyroid gland, the administration of the hormone in question against the background of aminasin results in the same ultramorphological structural changes of the gland which are observed after injection of aminasin alone, causing a decreased functional activity of the thyroid gland. The effect of intermedin upon the thyroid is supposed to be realized through those hypothalamus structures which are responsible for the regulation of the thyrotropic function of the hypophysis.