[Immunodiagnosis of chronic tonsillitis]. / Voprosy immunodiagnostiki khronicheskogo tonzilita.

Current methods of allergo- and immunodiagnosis of chronic tonsillitis are reviewed. Among them, attempts to use serological tests and reactions of cell type for defining course and form of chronic tonsillitis. Single tests, especially those basing on the suggested etiological factors, are thought uneffective. The available knowledge on functional characteristics of the lymphopharyngeal ring allows to offer some immunological tests for development of the laboratory-diagnostic algorithm aimed primarily at assessing feasibility of tonsil tissue repair for decisions on therapeutic policy rather than determination of the tonsillitis form.

[Morphological characteristics of central and peripheral organs of rat immune system in time course of adaptation to external low-dose gamma irradiation]. / Morfologicheskaia kharakteristika tsentral'nykh i perifericheskikh organov sistemy immuniteta krys v dinamike adaptatsii k vneshnemu gamma-oblucheniiu v malykh dozakh.

The morphohistochemical changes in immune system lymphoid organs and skin of rats, exposed to single and fractionated gamma-radiation (0.35 Gy) were studied during 1 month. It has been revealed that single irradiation didn't significantly influence, while the fractionated irradiation in equal dose resulted in lymphoid cells elimination from thymus and spleen and changes in skin and bone marrow cells subsets, inducing the increase of lymphoid cells number and activation of tissue basophils and macrophages reaction.

[The role of the thymus gland in the development of adaptation reactions of the immune system during fractionated low-level gamma irradiation]. / Uchastie vilochkovoi zhelezy v razvitii adaptatsionnykh reaktsii immunnoi sistemy pri fraktsionirovannom gamma-obluchenii v malykh dozakh.

In experiments with normal and thymectomized rats it has been revealed that exposure of normal animals to 0.35 Gy of gamma-radiation induces changes in blood cells subsets, depression of NK functional activity, decrease in polymorphonuclear leukocyte basal chemiluminescence level, suppression of the delayed type of hypersensitivity reaction and stimulation of local IgE-synthesis in respiratory organs. At the same time irradiation of adult thymectomized animals did not resulted in significant fluctuations in cellular and humoral immunity indices as well as blood cells functional activity level. Some mechanisms of radiation-induced immune system disturbances mediated via thymus are discussed.

[The functional dynamics of the system of immunity in rats during adaptation to single and fractionated exposures to low doses of external gamma irradiation]. / Dinamika sostoianiia sistemy immuniteta krys v protsesse adaptatsii k odnokratnomu i fraktsionirovannomu vozdeistviiu malykh doz vneshnego gamma-oblucheniia.

The content of serum corticosterone so as immunological and nonspecific reactivity in rats exposed to single or fractionated gamma-radiation (0.35 Gy) were studied during 1 month. It has been revealed that corticosterone level, dynamics of absolute amount of leucocytes, lymphocytes, Rc-receptor-bearing cells in blood, relative content of FcR(+)-cells in bone marrow, spleen and peripheral lymph nodes of irradiated animals depend on the scheme of irradiation. Single irradiation didn't significantly influence natural and antibody-dependent killer cells activity and basal chemiluminescence level of polymorphonuclear cells, while the fractionated irradiation in equal dose induced considerable fluctuations of these parameters. The direction and intensity of the disturbances depend on the time after irradiation.

[The biological effects in animals in relation to the accident at the Chernobyl Atomic Electric Power Station. 8. The status of cellular immunity in different generations of rats]. / Biologicheskie éffekty u zhivotnykh v sviazi s avariei na Chernobyl'skoi AES. Soobshchenie 8. Sostoianie keltochnogo immuniteta u raznykh pokolenii krys.

In studying immunity in laboratory rats of different generations (P, F1 and F2) brought up in Chernobyl in 1989-1990 the authors have revealed the development of leuko- and lymphopenia; decrease in the absolute content of immunocompetent cells bearing Fc receptors to IgG; stable and long-lasting suppression of blood NK cell activity; reduction of antibody-dependent cytotoxicity; and changed ability of blood lymphocytes to interact contactly with allogenic mast cells. The most considerable disorders have been found in 6- and 9-month-old F1 rats and in 3- and 6-month-old F2 rats.

[The effect of acute alcoholic intoxication on the body's immunologic and biochemical indices]. / Vliianie ostroi alkogol'noi intoksikatsii na immunologicheskie i biokhimicheskie pokazateli organizma.

Acute experimental intoxication in rats produced essential changes of the absorptive capacity of neutrophilic blood granulocytes, proteolytic activity, level of proteinase inhibitors and content of blood plasma fibrinogen. Female rats showed a distinct reduction of the activity of natural killer cells. Alcohol had no essential effect on the production of hemolytic antibodies as well as reagins in the respiratory organs.

[Suppressive effect of autologous thymocytes abolished by prednisolone]. / Supressornoe deistvie autologichnykh timotsitov, otmeniaemoe prednizolonom.

The authors studied the effect of autothymocytes on the hemolysin-producing cells formation in different lymphoid organs of young rabbits. Intravenous injection of thymocytes proved to suppress the formation of antibody-producing cells in the spleen of animals. Prednisolone treatment of thymocytes before their injection cancelled the suppressive effect of autologous thymocytes.