RESUMO
An appreciable increase in the number of aberrant lymphocytes was detected in the peripheral blood of patients with febrile form of tick-borne encephalitis (TBE). This increase peaked during week 2 of the infectious process and was paralleled by a decrease in the count of natural killer cells. By the end of the acute period of neuroinfection the number of cells with structural chromosome aberrations decreased, but still surpassed the control (donor blood). Genetically unstable cells were eliminated predominantly at the expense of lymphocytes with chromatid disorders, while the count of CD16-expressing lymphocytes increased. The intensity of reparative DNA synthesis was suppressed during the entire acute period of tick-borne encephalitis.
Assuntos
Aberrações Cromossômicas , Encefalite Transmitida por Carrapatos/sangue , Encefalite Transmitida por Carrapatos/genética , Linfócitos/ultraestrutura , Adulto , DNA/biossíntese , Reparo do DNA , Vírus da Encefalite Transmitidos por Carrapatos/patogenicidade , Feminino , Febre/virologia , Humanos , Linfócitos/sangue , Linfócitos/imunologia , Masculino , Pessoa de Meia-Idade , Receptores de IgG/análiseRESUMO
We studied metabolic and functional activity of peripheral blood phagocytes from patients with febrile tick-borne encephalitis. Phagocytic activity of neutrophils determining nonspecific resistance of the organism progressively increased, while metabolic activity decreased. Secretion of nitric oxide by peripheral blood mononuclear phagocytes was suppressed, while phagocytic functions of these cells remained unchanged.
Assuntos
Encefalite Transmitida por Carrapatos/sangue , Monócitos/fisiologia , Neutrófilos/fisiologia , Doença Aguda , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Monócitos/metabolismo , Neutrófilos/metabolismo , Óxido Nítrico/sangue , Óxido Nítrico/metabolismoRESUMO
Surface relief and configuration of peripheral blood erythrocytes were studied under a scanning electron microscope in 42 patients with paranoid schizophrenia during the active phase and remission. Control group consisted of 30 mentally and somatically healthy donors. The count of functionally intact biconcave discocytes was appreciably (p < 0.001) decreased and the incidence of transitory, prehemolytical, and degenerative forms of erythrocytes increased in the patients. Morphological restructuring of the erythrocyte population was universal in the patients with different duration of the schizophrenic process.
