Sudden unexpected death from an undiagnosed histiocytic sarcoma in an adolescent female.

A previously well 15-year-old female who was awaiting medical investigations for a proptosed right eye collapsed and died suddenly while walking. Postmortem examination revealed diffuse distortion and infiltration of multiple organs by a suspected neoplastic process. Histology confirmed the invasion of multiple organs by atypical cells and myocardial infiltration was the likely cause of death. An extensive panel of immunohistochemistry established the diagnosis of a histiocytic sarcoma. Sudden unexpected death due to a clinically undiagnosed neoplasia in childhood and adolescence is uncommon. This is the first report of a histiocytic sarcoma causing sudden unexpected death and highlights the importance of considering undiagnosed hematological malignancies when examining a case of sudden death at postmortem.

Subungual sarcoidosis: a rare entity.

Sarcoidosis is a multisystem disease, and nail involvement is rare. We report a case of subungual sarcoidosis involving both great toes. This was treated with intradermal steroid injections, with good symptomatic and clinical response.