RESUMO
To assess the therapeutic effects of morniflumate, a new non-steroidal anti-inflammatory drug, a controlled study versus imidazole-2-hydroxybenzoate, both combined with amoxicillin, and antibiotic therapy alone was carried out on 60 patients, aged 18 to 60 with flare-ups of chronic bronchitis. After administering morniflumate, all the clinical parameters assessed (objective auscultation, cough, expectoration, exertional dyspnoea, chest pain, hyperthermia) had improved. The modifications observed in this group were greater and earlier when compared to those of the control groups. No significant variations of laboratory parameters nor any particular side-effects were reported.
Assuntos
Anti-Inflamatórios não Esteroides/uso terapêutico , Bronquite/tratamento farmacológico , Ácido Niflúmico/análogos & derivados , Adolescente , Adulto , Antibacterianos/uso terapêutico , Anti-Inflamatórios não Esteroides/efeitos adversos , Bronquite/fisiopatologia , Doença Crônica , Quimioterapia Combinada , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Ácido Niflúmico/efeitos adversos , Ácido Niflúmico/uso terapêutico , RecidivaRESUMO
The pulmonary primary localization of the histiocytosis X is rather rare. We describe here a case of histiocytosis X with a localization exclusively at pulmonary level in a 38 years old young man who is a heavy smoker. A dry cough, asthenia and an increasing dyspnoea were the first symptoms of the disease. The radiological picture showed a widespread pulmonary intersticepathy. The diagnosis has been obtained testing some fragments of the pulmonary parenchyma taken through a diagnostic thoracotomy with an electron microscope.
Assuntos
Histiocitose de Células de Langerhans/diagnóstico , Pneumopatias/diagnóstico , Adulto , Humanos , MasculinoAssuntos
Asma/tratamento farmacológico , Derivados da Atropina/uso terapêutico , Bronquite/tratamento farmacológico , Etanolaminas/uso terapêutico , Fenoterol/uso terapêutico , Ipratrópio/uso terapêutico , Pneumopatias Obstrutivas/tratamento farmacológico , Adolescente , Adulto , Idoso , Asma/fisiopatologia , Bronquite/fisiopatologia , Combinação de Medicamentos , Avaliação de Medicamentos , Feminino , Fluxo Expiratório Forçado , Volume Expiratório Forçado , Humanos , Pneumopatias Obstrutivas/fisiopatologia , Masculino , Pessoa de Meia-IdadeRESUMO
Psychiatric disorders in a sample of spouses of probands with recurrent Primary Affective Disorders (PAD) and in their first degree relatives were evaluated and compared with those in the spouse of control subjects without psychiatric illnesses. No differences were found in the risk for PAD, but spouses of PAD patients and their respective first degree relatives manifested a greater incidence of affective spectrum disorders.
Assuntos
Transtornos do Humor/genética , Família , Feminino , Humanos , Masculino , Risco , SociologiaRESUMO
Seventy-two spouses of subjects with recurrent primary affective disorders (PAD), were investigated for the presence of psychiatric disorders in their lives and in those of their first degree relatives, and compared with 71 spouses of non-psychiatrically ill control subjects. No difference was found in the risk for PAD; on the other hand spouses of affective patients manifested a greater occurrence of psychiatric disorders belonging to the affective spectrum, as did their respective first-degree relatives.
Assuntos
Transtornos Psicóticos Afetivos/genética , Casamento , Transtorno Bipolar/genética , Transtorno Depressivo/genética , Família , Feminino , Humanos , Masculino , RiscoRESUMO
The authors have investigated HLA-haplotype zygotic assortment in 21 families with multiple cases of affective disorders and in 19 sibling pairs discordant for the disease. The finding of excess similarity between affected sibs stressed the possibility of the existence of genes in the HLA chromosomal region which are involved in the susceptibility to affective disorders. The mode of inheritance of such an hypothesized DS gene was also tested and some theoretical implications are discussed.
Assuntos
Sintomas Afetivos/genética , Antígenos HLA , Feminino , Frequência do Gene , Antígenos HLA/análise , Haploidia , Humanos , MasculinoRESUMO
HLA phenotype distribution was investigated in 91 affective patients. Significant increases over those of the control population were found in HLA-A 29 and in Bw 22 frequencies, while A 10 and A 30 were decreased. No significant difference was shown between the two clinical subgroups (41 unipolar patients and 50 bipolar ones). On comparing our data with those from other authors, Bw 16 was significantly increased. However, a high degree of heterogeneity was also shown for this antigen. Of some interest is the finding that relapsed and non-relapsed patients during long-term lithium therapy display diverging HLA phenotype distributions, with B 5 increased among the non-relapsed subjects.
Assuntos
Transtorno Bipolar/imunologia , Depressão/imunologia , Antígenos HLA/análise , Fenótipo , Transtorno Bipolar/tratamento farmacológico , Transtorno Bipolar/genética , Depressão/tratamento farmacológico , Depressão/genética , Suscetibilidade a Doenças , Etnicidade , Humanos , Itália , Lítio/uso terapêutico , RecidivaRESUMO
First and second degree relatives of 99 probands with affective disorders (49 unipolar and 50 bipolar subjects) were studied. The high risk values obtained for affective disorders were shown to be compatible with those found by other authors, although the prevalence of the illness in the population of Lombardy appears to be much lower than in other countries. Very low rates of suicide and alcoholism were found in our sample. Data obtained by analysis of the affected pairs of relatives rule out the hypothesis of a dominant X-linked gene if the bipolar and the unipolar forms are considered genetically separated entities. Results compatible with a polygenic condition, partially shared by bipolar patients, were found using Slater's and Smith & Falconer's methods. Our data, however, cannot rule out the dominant hypothesis.
