[Biochemical monitoring of the fetoplacental unit in pregnant women with a hypotrophic fetus]. / Biochemické monitorování fetoplacentární jednotky tehotné zeny s hypotrofickým plodem.

The authors investigate the importance of examination of total urinary oestrogens (ET), oestriol (E3) trophoblast-specific beta-1-globulin (SP1) and alpha-1-antrypsin (A1AT) in the blood in a group of 56 pregnant women with suspection of a hypotrophic foetus. They made 192 analyses of ET, 144 E3; 153 SP1; 124 A1AT. With regard to the state of the neonate after delivery they divided the group into sub-groups with a eutrophic neonate and the group with a hypotrophic neonate, and the group with a hypotrophic neonate. They proved by statistical methods a different incidence of pathological values of ET, E3 and SP1 in the two sub-groups. A1AT rises in both sub-groups with advancing pregnancy. The incidence of pathological values was not significant. Assessment of ET is indispensible in any obstetric department; repeated examination is necessary, as one result does not provide adequate information on the function of the placenta and state of the foetus. To confirm the diagnosis, several biochemical parameters should be assessed.