1.
J Am Chem Soc
; 137(22): 7095-8, 2015 Jun 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26029849
RESUMO
A convergent total synthesis of the architecturally complex indole diterpenoid (-)-nodulisporic acid D has been achieved. Key synthetic transformations include vicinal difunctionalization of an advanced α,ß-unsaturated aldehyde to form the E,F-trans-fused 5,6-ring system of the eastern hemisphere and a cascade cross-coupling/indolization protocol leading to the CDE multisubstituted indole core.