Seasonal variation of decompensated heart failure admissions and mortality rates in sub-Saharan Africa, Cameroon.

BACKGROUND: Epidemiological data of heart failure (HF) decompensation from the northern hemisphere suggests higher rates during winter. OBJECTIVES: We aimed to explore the seasonal variation in decompensated HF admission and mortality rates in a country with equatorial climate. METHODS: We conducted a retrospective cross-sectional study by chart review of the admission, discharge registries and patient files from 2016 to 2018 in the cardiology unit of the Yaoundé Central Hospital, Cameroon. Data was collected on HF morbidity and mortality from the registers and patients' files. Corresponding seasonal climatic data was obtained from the meteorology office of the Cameroonian ministry of transports. Analysis of variance and Chi-square test were respectively used to compare the continuous and categorical data between across seasons. Correlation between continuous data was assess with the Spearman correlation. RESULTS: Decompensated HF accounted for 636 (36.2%) out 1755 cardiology unit admission and an 18% lethality rate. Decompensated HF admission, mortality and lethality rates were respectively 38.2%, 6.7% and 17.9% higher during the long rainy season (all P values>0.05). We observed a borderline-to-significant inverse linear continuous correlation between monthly temperatures and admission rate (r=-0.301; P=0.070), lethality rate (r=-0.361; P=0.030) and mortality rate (r=-0.385; P=0.020). There was no significant difference of the distribution of precipitating factors between seasons. CONCLUSION: Although statistically insignificant, decompensated HF admissions and mortality increase in rainy season where the temperature is lower in an equatorial climate.

[Endomyocardial fibrosis in Cameroon: Echocardiographic and clinical description of a pediatric series in Yaoundé]. / Fibrose endomyocardique : description clinique et échocardiographique d'une série pédiatrique camerounaise.

BACKGROUND: Endomyocardial fibrosis is a restrictive cardiomyopathy that causes heart failure. It is characterized by the fibrotic thickening of the endocardium, sometimes involving the myocardium as well. The lesion generally lies at the apices or inflow tracts of one or both ventricles, associated with more or less severe alteration of the valves. It is a disease of the intertropical regions but is not well known in Cameroon. In this study we describe the first series seen in a pediatric hospital in Cameroon. PATIENTS AND METHODS: A retrospective study was conducted in a pediatric hospital in Yaoundé involving children who had been diagnosed with endomyocardial fibrosis after echocardiographic investigation. We collected the clinical and paraclinical data from consultation records and medical files. RESULTS: Between January 2006 to December 2013, we registered 1430 patients with a cardiac anomaly in our center. Endomyocardial fibrosis was found in 46 patients. Neither sex predominated. Ages at the time of diagnosis varied between 2 and 17 years. Most of the patients were between 5 and 15 years old (80.4 %), with a median of 10 years (interquartile range, 7-13 years). The main complaints were breathlessness, cough, abdominal distension, abdominal, and loss of appetite. Apart from the hyperpigmentation of the lips observed in all our patients, dyspnea was the most frequent physical sign and the diagnosis was made at a time when signs of heart failure were preponderant. Growth retardation was found in all the children examined. All patients were underweight with a median weight for age found below the 25th percentile of the norms according to the National Health Statistics. Lower limb edema was absent even in the presence of voluminous ascites. All subjects had hyperpigmented lips. Despite the cyanotic appearance of the lips, pulse oximetry always gave a normal oxygen saturation level and no cyanosis was seen elsewhere. None of the patients had nail clubbing. Fibrosis more often affected the right ventricle (45/46 patients). The apical obliteration by fibrotic material was found in 43 (93.5 %) patients. Moreover, 36 (78.3 %) patients had pericardial effusion: mild to moderate in 32 subjects and abundant in four subjects. Hypereosinophilia was noted in 57.5 % of the patients. Atrial fibrillation was found in six out of 15 patients who had an electrocardiogram done. CONCLUSION: The modes of clinical presentation of endomyocardial fibrosis are not sufficiently well known in our context. Despite its insidious progression, certain signs such as weight loss and hyperpigmented lips could be very helpful for screening and easing orientation of parents and heath personnel, thus enabling early referral for appropriate investigation. The presence of bulky ascites without edema of the lower extremities should be viewed as strongly suggestive.

Ectopia cordis. A report of two cases in Cameroon.

We report two cases of ectopia cordis in two children aged one day and twenty months respectively. A one day old newborn had complete thoracic ectopia cordis associated with an internal cardiac defect and severe thoracic and abdominal wall malformations. Our centre does not have the facilities to manage complex congenital defects and prior to being transferred to a cardiac centre, the neonate died on the second day of admission. A 20-month old baby had partial ectopia of the heart and a defect in the abdominal wall. He had no major congenital cardiac defect and has remained clinically stable with no life threatening symptoms.

[Giant aneurysm of the pulmonary artery: a case report]. / Anévrisme géant de l'artère pulmonaire: à propos d'un cas.

Pulmonary artery aneurysm is a rare condition accounting for less than 1% of all intra thoracic aneurysms. This paper reports a case of giant aneurysm of the trunk and branches of the pulmonary artery, which was discovered incidentally on a computed tomography angiogram in a 48-year-old man with a past history of pulmonary tuberculosis. Besides the aneurysm there was dilation of the pulmonary annulus with massive pulmonary regurgitation, a tight mitral stenosis and sequelae of pleural and pulmonary tuberculosis. The patient is being followed-up with medical treatment and has been stable clinically for the last ten months.

High levels of discordance between office-based and ambulatory blood pressure measurements for diagnosing optimal blood pressure control in high-risk diabetic populations from a developing country.

This study investigated the concordance between office-based blood pressure (BP) readings and ambulatory BP monitoring (ABPM) in 51 consenting type 2 diabetes patients (25 males) in Cameroon with hypertension who had been receiving stable treatment for at least 3 months. The prevalence of optimal BP control was 63% based on office measurements and 23% based on ABPM. Agreement between the two methods was poor (kappa statistic: 0.15; 95% confidence interval: -0.08 to 0.29). Using ABPM as the standard, office BP was helpful for ruling out optimal BP control (specificity: 75%), but not for ruling it in (sensitivity: 41%). Our results suggest that ABPM should be recommended in such settings as ours only for those patients who have already achieved stable optimal BP control according to office measurements.

[Cardiac surgery in Cameroon. Results at one year of the pilot phase]. / Chirurgie cardiaque au Cameroun. Résultats à un an de la phase pilote.

In the framework of implementation of his national program for control and prevention of cardiovascular diseases, Cameroonian government has set up a cardiac surgery project. We report in this manuscript results of one year follow up of the patients operated during the pilot phase. From September 22 till 26, 2008, 11 patients have been operated in Cameroun. Surgical procedures were 5 mitral mechanic valve replacement, 2 aortic mechanic valve replacement, 1 atrial septal defect closure, 2 pace maker implantation. No intrahospital death was observed. One patient died at 11th month after the operation due to mitral valve thrombosis and attributed to lack of compliance. One patient presented low cardiac output, pneumonia and a pleural effusion. 2 patients presented 2 minor complications consisting of pericarditis and superficial wound infection. The results of the pilot phase of cardiac surgery in Cameroon are effective. However, the sustainability of the program require human, material capacity building, and funding mechanism as well.

[A new look at adult chronic heart failure in Africa in the age of the Doppler echocardiography: experience of the medicine department at Yaounde General Hospital]. / Nouveau regard sur l'insuffisance cardiaque chronique de l'adulte en Afrique à l'ère de l'échocardiographie Doppler: experience du service de médecine de l'Hôpital General de Yaoundé.

OBJECTIVE: Heart failure is a frequent and severe condition in Africa, yet few African data are available that take into account modern advances like echocardiography in diagnosis. This study aimed to characterize the epidemiological, clinical, etiologic and therapeutic features of heart failure at Yaounde General Hospital. METHODS: A descriptive study was carried from October 1998 to November 2001. One hundred and sixty-seven patients presenting with clinical and echocardiographic signs of heart failure were included, among which 99 men and 68 women, mean aged 57 years. RESULTS: Heart failure was the reason for 5,77% of all hospital admissions. Rehospitalisation rate was 8,33%, the prevalence 30% and overall mortality was 9,03%. 44% of patients were in class III of the NYHA and 7% in class IV. Dyspnoea was a constant symptom (95,20%); hepatomegaly was the most frequent physical finding (41,92%). Cardiac cavities were dilated and left ventricular ejection fraction was low in patients with systolic (70%) and combined (20%) dysfunction. Isolated diastolic heart failure accounted for 10% of cases. Main aetiologies were: Hypertension (54,49%), cardiomyopathies (26,34%) and valvular heart diseases (24,55%). Ischaemic heart disease was the fifth aetiology (2,39%). Medical treatment consisted of loop diuretics (90%), angiotensin-converting enzyme inhibitor (64,7%), digoxin (30,5%) and beta blockers (19,8%). CONCLUSIONS: The clinical syndrome of heart failure constitutes a major public health problem in Cameroon. Echocardiography is of paramount importance in confirming the diagnosis and precising its aetiology. Preventive and public health strategies need to be defined according to the local characteristics.