RESUMO
Two series of amides based on quinoline scaffold were designed and synthesized in search of photosynthesis inhibitors. The compounds were tested for their photosynthesis-inhibiting activity against Spinacia oleracea L. and Chlorella vulgaris Beij. The compounds lipophilicity was determined by the RP-HPLC method. Several compounds showed biological activity similar or even higher than that of the standard (DCMU). The structure-activity relationships are discussed.
Assuntos
Amidas/química , Hidroxiquinolinas/síntese química , Hidroxiquinolinas/farmacologia , Chlorella vulgaris/efeitos dos fármacos , Chlorella vulgaris/metabolismo , Clorofila/metabolismo , Cloroplastos/efeitos dos fármacos , Interações Hidrofóbicas e Hidrofílicas , Hidroxiquinolinas/química , Lipídeos/química , Estrutura Molecular , Fotossíntese , Spinacia oleracea/efeitos dos fármacos , Relação Estrutura-AtividadeRESUMO
A number of sweeteners contain a sulfonyl group. In our current search for new glucophores several new compounds containing such group were obtained. A series of novel 1-phenylsulfonylcyklohexanecarboxylic acids and 2-arylsulfonylalkanecarboxylic acids was obtained and evaluated for their sweet taste quality. It has been found that methyl substituents are of the key importance for the activity of these compounds.
