RESUMO
Cerebral glucose metabolism was studied in 20 underweight anorectic girls and in 10 age- and sex-matched healthy volunteers using positron emission tomography with (18-F)-fluorodeoxy-glucose. Both groups were scanned during rest, with eye closed and with low ambient noise. Compared to controls, the underweight anorectic group showed a global hypometabolism (p = .002) and an absolute (p < .001) as well as relative (p < .01) hypometabolism of glucose in cortical regions, with the most significant differences found in the frontal and the parietal cortices. Within the underweight anorectic and the control groups, no correlations were found between absolute or relative rCMRGlu and BMI, anxiety scores, or Hamilton scores of depression. Different factors might explain this reduction of glucose metabolism in anorexia nervosa. It might be the consequence of neurophysiological or morphological aspects of anorexia nervosa and/or the result of some associated symptoms such as anxiety or depressed feelings. Supported by cognitive studies, we can also hypothesize a primary corticocerebral dysfunctioning in anorexia nervosa.
Assuntos
Anorexia Nervosa/diagnóstico por imagem , Glicemia/metabolismo , Encéfalo/diagnóstico por imagem , Tomografia Computadorizada de Emissão , Adolescente , Adulto , Anorexia Nervosa/psicologia , Nível de Alerta/fisiologia , Gânglios da Base/diagnóstico por imagem , Índice de Massa Corporal , Mapeamento Encefálico , Córtex Cerebral/diagnóstico por imagem , Comorbidade , Desoxiglucose/análogos & derivados , Desoxiglucose/metabolismo , Transtorno Depressivo/diagnóstico por imagem , Transtorno Depressivo/psicologia , Dominância Cerebral/fisiologia , Feminino , Fluordesoxiglucose F18 , Humanos , Inventário de PersonalidadeRESUMO
Alterations of nocturnal sleep have been widely described in affective disorders. However, little is known about putative daytime sleep and to what extent daytime sleep could interfere with nocturnal sleep. The goal of this study was to investigate 24-hr sleep patterns in 12 depressed patients hospitalized for a major depressive disorder and in 10 control subjects studied under the same experimental conditions. Patients and controls were free to sleep whenever they chose, and sleep recordings were performed using the Oxford Medilog System during 60 hr. Daytime sleep episodes were detected in 50% of the patients and in 60% of the controls. Patients took naps at various times of the day, whereas controls napped in the early afternoon, during the well-known "postlunch dip". Thus daytime sleep prevalence was similar in both groups; however, the biphasic distribution of sleep observed in controls disappeared in the patients. Napping did not affect subsequent nocturnal sleep in either group.
