Locally advanced lymphoepithelial carcinoma of the larynx/hypopharynx: A case report.

Lymphoepithelial carcinoma (LEC) is an uncommon, aggressive cancer that affects mainly the nasopharynx (a form that is closely related to the Epstein-Barr virus). LEC of the larynx/hypopharynx is extremely rare, accounting for only 0.2% of malignant tumors of the larynx. This study describes a case of locally advanced LEC of the larynx/hypopharynx with effective response to chemoradiation (an option that spares the patient from the risks of surgical resection). A 60-year-old sedentary, hypertensive male patient with a previous history of smoking and alcohol abuse received a histopathological diagnosis of locally advanced LEC of the larynx/hypopharynx in May 2018. He underwent treatment with chemoradiation and exhibited a complete clinical response. At about 3 years of follow-up, the patient is currently alive, free from disease and has not presented any tumor recurrences.

SURGICAL BREAST CLIPPING FOR DELIMITATION OF RADIOTHERAPY DOSE IN BREAST CANCER / Clipping de mama cirúrgico para delimitação de dose radioterápica no câncer de mama

Objective: To evaluate the benefit of radiotherapy planning, involving the use of surgical clips in conservative treatment of earlystage breast cancer. Methods: Retrospective cohort. Twelve (12) breast cancer female patients were retrospectively evaluated. These women had undergone breast-conserving treatment in which the tumor bed had been demarcated with titanium 200 surgical clips to guide breast boost radiotherapy. Volumes were calculated. Radiotherapy planning in the same patient with boost dose guided by metal clips was compared to planning guided by surgical scar or by imaging tests prior to surgical treatment. Results: A reduction of 36.7% in total volume of the irradiated breast (p=0.022), a reduction of 55.7% in boost volume (p=0.001), a reduction of 35.9% (p=0.001) in the breast volume receiving the prescribed boost dose and a reduction of 4.5% (p=0.014) in the maximum dose applied to the lung were shown. Conclusions: Clip placement in surgical bed following conservative treatment for breast cancer determined a reduction of 36.7% in irradiated breast volume and use of a lower dose of irradiation.

Objetivo: Avaliar o benefício do planejamento radioterápico, envolvendo o uso de clipes cirúrgicos em tratamento conservador de estágio inicial de câncer de mama. Métodos: coorte retrospectiva. Doze (12) pacientes do sexo feminino com câncer de mama foram avaliadas retrospectivamente. Estas mulheres foram submetidas a tratamento conservador da mama em que o leito do tumor foi demarcado com grampos cirúrgicos de titânio 200 para orientar a radioterapia de mama. Os volumes foram calculados. O planejamento de radioterapia no mesmo paciente com dose de reforço guiada por clipes metálicos foi comparado ao planejamento guiado por cicatriz cirúrgica ou por exames de imagem antes do tratamento cirúrgico. Resultados: Foram observadas uma redução de 36,7% no volume total da mama irradiada (p = 0,022), uma redução de 55,7% no volume do reforço (p = 0,001), uma redução de 35,9% (p = 0,001) no volume mamário recebendo a dose de reforço prescrita e uma redução de 4,5% (p = 0,014) na dose máxima aplicada ao pulmão. Conclusões: A colocação do clipe no leito cirúrgico após tratamento conservador para câncer de mama determinou uma redução de 36,7% no volume mamário irradiado e o uso de menor dose de irradiação