IgG subclasses serum concentrations in a population of children with Down syndrome: comparative study with siblings and general population.

Serum total IgG and subclasses were determined in three different groups of children: with Down syndrome, their siblings and general pediatric population. Several cases of IgG2 and IgG4 deficiency were identified, predominantly in children with Down syndrome. The differences, considering three age groups, were statistically significant for both groups in relation to the general population group, with an increase of IgG1 and IgG3 and a decrease in serum concentrations of IgG2 and IgG4. Down syndrome children and their siblings tend o have a similar variation of the IgG4 serum concentration levels (P < 0.05). The mechanisms of this concordance are not well understood. The results point out that an adequate strategy to improve the immune status of Down syndrome children could have a positive manifestation in the immune profile of their brothers.

IgG subclasses serum concentrations in a population of children with Down syndrome: Comparative study with siblings and general population

Serum total IgG and subclasses were determined in three different groups of children: with Down syndrome, their siblings and general pediatric population. Several cases of IgG2 and IgG4 deficiency were identified, predominantly in children with Down syndrome. The differences, considering three age groups, were statistically significant for both groups in relation to the general population group, with an increase of IgG1 and IgG3 and a decrease in serum concentrations of IgG2 and IgG4. Down syndrome children and their siblings tend o have a similar variation of the IgG4 serum concentration levels (P < 0.05). The mechanisms of this concordance are not well understood. The results point out that an adequate strategy to improve the immune status of Down syndrome children could have a positive manifestation in the immune profile of their brothers (AU)

Se determinaron el suero total IgG y subclases en tres grupos distintos de niños: con síndrome de Down, sus hermanos y población pediátrica general. Se identificaron varios casos de deficiencia en suero IgG2 e IgG4, principalmente en niños con síndrome de Down. Las diferencias, considerando tres grupos de edad, resultaban estadísticamente significativas en ambos grupos en relación con el grupo de población general, con un aumento de IgG1 e IgG3 y un descenso de las concentraciones de suero de IgG2 e IgG4. Los niños con síndrome de Down y sus hermanos tienen tendencia a presentar una variación similar de los niveles de concentración de suero IgG4 (p < 0,05). Los mecanismos de esta concordancia no se entienden demasiado bien. Los resultados indican que una estrategia adecuada para mejorar las condiciones inmunológicas de los niños con síndrome de Down podría tener una manifestación positiva en el perfil inmunológico de sus hermanos (AU)