[Mental health and work: a discussion on the connection between work and diagnosis, based on daily practice]. / Saúde mental e trabalho: uma reflexão sobre o nexo com o trabalho e o diagnóstico, com base na prática.

Seven cases of workers selected among 150 who had undergone psychiatric treatment at the Workers' Health Reference Centers in Santo Amaro and André Gabois from 1994 to 1997 were presented for a detailed analysis characterizing work situations and discussing definition of the diagnosis and causal connections with work. The qualitative case study provides a thematic analysis of the patient history and files. Work situations are characterized by: unhealthy working conditions, problems related to work organization, inadequate human resources management, and urban violence. Symptoms included: fear, anxiety, depression, nervousness, tension, fatigue, malaise, loss of appetite, sleep disorders, and psychosomatic disorders (gastritis, hypertension); in addition, workers were unable to forget about work while off the job. Diagnosis varied. Three cases involved post-traumatic syndrome. Two cases involved organic psychosis linked to accidents or exposure to neurotoxic chemical products. Cases also included neurotic syndromes of fatigue, depression, and paranoia, as well as adaptation and reaction to acute stress. In all of the cases it was possible to relate the clinical picture to the work situation.

Dynamics of the antibody response in patients with therapeutic or spontaneous cure of American cutaneous leishmaniasis.

The antigen specificity and the level of the antibody response were analysed in Perambuco State, Brazil, in sera collected in 1995-96 from 58 patients with clinical American cutaneous leishmaniasis (ACL), 25 ACL patients with apparent cure after chemotherapy with meglumine antimonate, and 10 ACL patients with spontaneous cure. Assessment was by immunoblot analysis, ELISA and indirect immunofluorescence, with Leishmania (Viannia) braziliensis antigens, with a particular interest in evaluating whether the dynamics of the antibody response could be useful to monitor clinical cure. A clear decrease of IgG antibody reactivity was noticed after clinical healing, for all of the antigens analysed, with the exception of the 19 kDa antigen, whose recognition frequency in fact increased in the spontaneously cured patients, suggesting that this antigen may play a role in protective immunity against cutaneous leishmaniasis. The recognition frequencies of the most frequently recognized antigens (27 and 30 kDa antigens) diminished approximately 2-fold in patients clinically healed, suggesting that they could be useful as a marker of cure of ACL. In addition, some of the healthy individuals living in endemic areas presented the same immunoblotting pattern of reactivity observed in active ACL, possibly representing asymptomatically infected individuals.

Identification of potentially diagnostic Leishmania braziliensis antigens in human cutaneous leishmaniasis by immunoblot analysis.

The antibody response in patients with American cutaneous leishmaniasis was analyzed by immunoblotting with soluble and insoluble antigens of Leishmania braziliensis. The recognition of the 27- and/or 30-kDa soluble antigens was considered relevant for the diagnosis of cutaneous leishmaniasis. Immunoblotting was found to be significantly more sensitive and specific than indirect immunofluorescence and enzyme-linked immunosorbent assay.

Demographic-sanitary indicators in Mozambique.

PIP: Data from two inquiries conducted in Mozambique in 1979 are analyzed in order to estimate mortality and fertility rates. The results are compared with estimates from the 1970 general census, and the accuracy of the data is assessed. (summary in FRE, ITA)^ieng