Hyperbaric Oxygen Therapy for Second-Degree Burn Healing: An Experimental Study in Rabbits.

BACKGROUND: The wound healing process includes inflammation, proliferation, and remodelling phases, the main features of which are inflammation, neoangiogenesis, and epithelialization. Hyperbaric oxygen therapy (HBOT) is one modality postulated to improve wound healing. The objective of this study was to determine whether HBOT could improve selected features of burn wound healing in an experimental rabbit model. METHODS: Researchers conducted an experimental study with 36 rabbits given second-degree burns. Subjects were separated into two groups: a control group (n = 18) and an intervention group that was given HBOT at 2.4 atmospheres absolute for 6 days (n = 18). The main outcome measure was wound healing. RESULTS: Compared with the control group, the HBOT group showed more robust inflammatory cells (P = .025) and epithelialization (P = .024), but no significant difference in angiogenesis (P = .442). CONCLUSIONS: The authors conclude that HBOT may improve second-degree burn healing by increasing inflammatory cell migration and re-epithelialization.

[Study of the Consumers' preference on the universal health coverage development strategy through health mutual in Ziguinchor Region, Southwest of Senegal]. / Étude de la préférence des usagers sur les stratégies de développement de la couverture sanitaire universelle à travers les mutuelles de santé dans la région de Ziguinchor au sud-ouest du Sénégal.

In Senegal, the informal and rural sector that accounts for over 80% of the population is covered only up to 7% by a health insurance system. That is why, for the implementation of development strategy of the universal health coverage (UHC) through mutual health insurance providers, the Government of Senegal has focused on this sector. The objective of this study was to assess the consumer's preference on the UHC development strategies through mutual health insurance providers. This was a qualitative and exploratory study based on a literature review, and indepth interview with the heads of households. It was also based on focus groups of people with and without health mutual membership, and the Expert Committee meetings. The results showed that the most critical attributes in the decision-making of consumers to join the health mutual in Ziguinchor were the membership units; the content of the benefit package, the payment modalities of the premium, the premium amount, the availability of transportation, the co-payment level, convention arrangement with health facilities, and health mutual governance. For a successful implementation of the UHC development strategy through health mutual organizations, policymakers should explore the possibility of introducing the modality of payment in kind, the revision of the co-payment amount, and the promotion of equity through the introduction of a differentiated premium contribution by income. They should also establish a crossborder strategy with The Gambia and Guinea-Bissau to improve health care access to people living in the borders. The promotion of innovative funding and risk equalization between health insurance schemes is also recommended. In areas where the microfinance institutions are well organized and structured their substitution to health mutuals should be an option the decision-makers have to explore.

[Intracranial empyemas: Epidemiological, clinical, radiological and therapeutic aspects. Retrospective study of 100 observations]. / Les empyèmes intracrâniens : aspects épidémiologiques, cliniques, paracliniques et thérapeutiques. Étude rétrospective de 100 observations.

INTRODUCTION: Intracranial empyema is a frequent complication of ear-nose-throat (ENT) infections. Limited studies have been carried-out on cerebral empyema during recent years in Senegal. Despite new imaging techniques, diagnostic and therapeutic problems as well as outcome still remain in our regions. We report our experience compared to that of the literature. The study focused on epidemiological aspects, difficulties in diagnosis and treatment as well as prognosis of this condition. METHODS: This was a retrospective study conducted from January 2008 to December 2011 of 100 clinical cases. Diagnosis was made based on contrast CT-scan. Twenty-one percent of patients received medical treatment alone, while 79% underwent surgery. The duration of the treatment varied from 4 to 8 weeks. The follow-up was clinical and radiological with a mean follow-up time of 12 months. RESULTS: Cerebral empyema represented 44.4 % of all intracranial suppuration cases and the mean age was 21 years. The etiology was ENT in 35%, meningitis 10%, unknown 25%. Localization was sub-dural in 57%, extra-dural in 22%, inter-hemispheric in 10% of the cases. Empyema was associated with an abscess in 7 cases. One case was located in the posterior fossa. The evolution was favorable in 78% of the cases and in 12.5% some neurologic sequelae were observed. Eleven patients died and 3% of the patients had recurrences. CONCLUSION: The frequency of intracranial empyema is still high in Senegal. Difficulties in diagnosis, therapeutics and low economic incomes account for the gravity of intracranial empyema. In spite of these risks, early stage and effective treatment is necessary to reduce the morbi-mortality, especially in young aged children.

Laser in situ keratomileusis versus arcuate keratotomy to treat astigmatism.

PURPOSE: To analyze the effectiveness of laser in situ keratomileusis (LASIK) and arcuate keratotomy (AK) to treat simple myopic, compound myopic, and mixed astigmatism. SETTING: Instituto de la Visión, Buenos Aires, Argentina. METHODS: This retrospective nonrandomized study comprised 821 cases treated with LASIK and 46 cases treated with AK. Patients were divided into 4 groups, which had the following preoperative cylinder corrections: simple myopic astigmatism (Group 1) (LASIK: n = 76, -3.91 diopters [D] +/- 1.29 [SD]; AK: n = 5, -3.85 +/- 0.65 D); compound myopic astigmatism up to 2.00 D (Group 2) (LASIK: n = 401, -1.69 +/- 0.76 D; AK: n = 14, -1.48 +/- 0.41 D); compound myopic astigmatism over 2.00 D (Group 3) (LASIK: n = 253, -3.61 +/- 0.89 D; AK: n = 16, -3.09 +/- 0.84 D); mixed astigmatism (Group 4) (LASIK: n = 91, +3.65 +/- 1.62 D; AK: n = 11, 4.39 +/- 0.92 D). RESULTS: Six months postoperatively, the cylinder's vector-corrected change was as follows: Group 1, LASIK 3.75 +/- 1.08 D, AK 3.16 +/- 0.84 D; Group 2, LASIK 1.55 +/- 1.12 D, AK 1.34 +/- 0.44 D; Group 3, LASIK 3.39 +/- 0.98 D, AK 2.70 +/- 1.21 D; Group 4, LASIK 3.77 +/- 1.43 D, AK 3.75 +/- 0.89 D. Respective mean uncorrected visual acuities in each group were as follows: Group 1, 0.71 +/- 0.12 and 0.60 +/- 0.12; Group 2, 0.83 +/- 0.12 and 0.78 +/- 0.24; Group 3, 0.78 +/- 0.18 and 0.48 +/- 0.24; Group 4, 0.69 +/- 0.21 and 0.55 +/- 0.18. CONCLUSIONS: The vector-corrected change and visual acuity achieved with LASIK were better, although not significantly, than those attained with AK except for the UCVA obtained with LASIK in eyes with compound myopic astigmatism over 2.00 D. Both methods proved to be safe.