RESUMO
BACKGROUND: Alveolar soft part sarcoma is a rare soft tissue sarcoma that is characterized by a pattern of slow growth with metastases to the lung, bone, and brain that is not responsive to conventional cytotoxic chemotherapy. OBSERVATIONS: We describe 2 patients, with a combined 19 years of treatment experience including multiple different chemotherapeutic and targeted therapy regimens, surgery, and radiotherapy. We also present a review of the literature regarding treatment options to highlight recent findings. CONCLUSIONS: Alveolar soft part sarcoma is an indolent, but persistently progressive disease. Novel therapeutic agents hold promise in its management.
Assuntos
Metástase Neoplásica/patologia , Sarcoma Alveolar de Partes Moles/terapia , Adolescente , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Criança , Terapia Combinada/métodos , Feminino , Humanos , Radioterapia , Sarcoma Alveolar de Partes Moles/patologia , Procedimentos Cirúrgicos OperatóriosRESUMO
Current therapy for acute lymphoblastic leukemia have resulted in cure rates over 80%. Relapses occur most frequently in the bone marrow. We report the unusual case of a young man who presented with an isolated kidney relapse after maintaining remission from acute lymphoblastic leukemia for over 6 years. Sites of extramedullary relapse and a review of the literature are discussed.
