RESUMO
Five right-handed children with Landau-Kleffner syndrome (LKS) who had disease onset between the ages of 3 and 9 years were studied with EEG and single-photon emission computed tomography (SPECT) before and, in four cases, after 6 months of corticosteroid treatment. EEG findings included both focal and generalized spikes as well as spike-wave discharges with bilateral temporal predominance. These increased markedly during sleep in 1 child, and continuous spike-and-wave complexes appeared during slow-wave sleep in another patient. Neuropsychological testing demonstrated verbal auditory agnosia. Magnetic resonance imaging (MRI) was performed in 4 children and was normal. Brain SPECT imaging demonstrated abnormal perfusion in the left temporal lobe in all patients. The response to corticosteroid therapy was mixed. Our findings reinforce the concept that LKS is a functional disease affecting the language-dominant brain areas. We conclude that SPECT imaging may be of diagnostic assistance in the evaluation of this syndrome of unknown etiology.
Assuntos
Encéfalo/diagnóstico por imagem , Síndrome de Landau-Kleffner/diagnóstico por imagem , Tomografia Computadorizada de Emissão de Fóton Único , Idade de Início , Criança , Pré-Escolar , Eletroencefalografia , Feminino , Lateralidade Funcional/fisiologia , Humanos , Síndrome de Landau-Kleffner/diagnóstico , Síndrome de Landau-Kleffner/tratamento farmacológico , Masculino , Testes Neuropsicológicos , Compostos de Organotecnécio , Oximas , Prednisona/uso terapêutico , Sono/fisiologia , Tecnécio Tc 99m Exametazima , Lobo Temporal/fisiologiaRESUMO
Os autores apresentam tres casos de lipossarcoma, salientando o papel decisivo da tomografia computadorizada no diagnostico, demonstrando a natureza gordurosa do tumor, a localizacao e dimensoes e permitindo sugerir a agressividade da neoplasia atraves do carater infiltrativo e da heterogeneidade da massa
