Bridging the gap between consciousness and matter: recurrent out-of-body projection of visual awareness revealed by the law of non-identity.

Consciousness is the most precious function of brain; however, there is an explanatory gap between consciousness and matter, which is deemed to affect the scientific research on consciousness. We believe that a methodological trap commonly present in scientific research and the incompleteness of logic are the true reasons that affect the research on consciousness. Here, a novel logic tool, the non-identity law, was extracted from physics and applied into the analysis of the visual dynamics related to naturalistic observation of night-shot still life, whose methodological approach is consistent with Descartes' matter-body-mind approach, breaking free from the methodological trap of current research. We show that visual system, the representative sensory system, has a postponed, recurrent out-of-body projection pathway from brain to observed object, besides the well-known feedforward signaling pathway available in existing literature, suggesting that human possesses an instinct of not only subjectively imaging (brain-generated imagery) but also projecting the image back onto the original or a particular place according to the clue of the manipulated afferent messenger light pathway. This finding adds a key piece of puzzle to the visual system. The out-of-body projection, coupled with neural correlates of consciousness (NCC), bridges the gap between consciousness and matter. This study in a self-contained and systematic manner provides a foundation for understanding the subjectivity and intentionality of human consciousness from the angle of visual awareness as well as the isomorphic relationships between unknowable original, private experience, and shareable expression (recording, calculus and deduction), showing that consciousness is obedient to certain rules rather than being unruly. The result paves the way for scientific research on consciousness and facilitates the integration of humanities and natural science.

Polarization-sensitive color in butterfly scales: polarization conversion from ridges with reflecting elements.

Polarization-sensitive color originates from polarization-dependent reflection or transmission, exhibiting abundant light information, including intensity, spectral distribution, and polarization. A wide range of butterflies are physiologically sensitive to polarized light, but the origins of polarized signal have not been fully understood. Here we systematically investigate the colorful scales of six species of butterfly to reveal the physical origins of polarization-sensitive color. Microscopic optical images under crossed polarizers exhibit their polarization-sensitive characteristic, and micro-structural characterizations clarify their structural commonality. In the case of the structural scales that have deep ridges, the polarization-sensitive color related with scale azimuth is remarkable. Periodic ridges lead to the anisotropic effective refractive indices in the parallel and perpendicular grating orientations, which achieves form-birefringence, resulting in the phase difference of two different component polarized lights. Simulated results show that ridge structures with reflecting elements reflect and rotate the incident p-polarized light into s-polarized light. The dimensional parameters and shapes of grating greatly affect the polarization conversion process, and the triangular deep grating extends the outstanding polarization conversion effect from the sub-wavelength period to the period comparable to visible light wavelength. The parameters of ridge structures in butterfly scales have been optimized to fulfill the polarization-dependent reflection for secret communication. The structural and physical origin of polarization conversion provides a more comprehensive perspective on the creation of polarization-sensitive color in butterfly wing scales. These findings show great potential in anti-counterfeiting technology and advanced optical material design.

Abnormal long-lasting synaptic plasticity and cognition in mice lacking the mental retardation gene Pak3.

Mutations in the Pak3 gene lead to nonsyndromic mental retardation characterized by selective deficits in cognition. However, the underlying mechanisms are yet to be elucidated. We report here that the knock-out mice deficient in the expression of p21-activated kinase 3 (PAK3) exhibit significant abnormalities in synaptic plasticity, specifically hippocampal late-phase long-term potentiation, and deficiencies in learning and memory. A dramatic reduction in the active form of transcription factor cAMP-responsive element-binding protein in the knock-out mice implicates a novel signaling mechanism by which PAK3 and Rho signaling regulate synaptic function and cognition.

Regulation of ADF/cofilin phosphorylation and synaptic function by LIM-kinase.

To investigate the role of the LIM-kinase (LIMK) family in the regulation of ADF/cofilin phosphorylation and synaptic function in the mammalian central nervous system (CNS), we conducted biochemical and electrophysiological analysis using mice that were genetically altered in the expression of LIMK-1 and LIMK-2. We showed here that while LIMK-2 knockout mice exhibited minimal abnormalities, the LIMK-1/2 double knockout mice were more severely impaired in both ADF/cofilin phosphorylation and excitatory synaptic function in the CA1 region of the hippocampus. These results indicate a critical role for the LIMK family in the regulation of ADF/cofilin and synaptic function in the brain.