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1.
Inorg Chem ; 63(27): 12538-12547, 2024 Jul 08.
Artigo em Inglês | MEDLINE | ID: mdl-38917470

RESUMO

Lung cancer poses a serious threat to people's lives and health due to its high incidence rate and high mortality rate, making it necessary to effectively conduct early screening. As an important biomarker for lung cancer, the detection of n-propanol gas suffers from a low response value and a high detection limit. In this paper, flower-like Ho-doped ZnO was fabricated by the coprecipitation method for n-propanol detection at subppm concentrations. The gas sensor based on the 3% Ho-doped ZnO showed selectivity to n-propanol gas. Its response value to 100 ppm n-propanol was 341 at 140 °C, and its limit of detection (LOD) was about 25.6 ppb, which is lower than that of n-propanol in the breath of a healthy person (150 ppb). The calculation results show that the adsorption of n-propanol on a Ho-doped ZnO surface releases more energy than isopropanol, ethanol, formaldehyde, acetone, and ammonia. The enhanced gas-sensing properties of the Ho-doped ZnO material can be attributed to the fact that the Ho-doping distorts the crystal lattice of the ZnO, increases the specific surface area, and generates a large amount of oxygen defects. In addition, the doped Ho partially forms a Ho2O3/ZnO heterojunction in the material and improves the gas-sensing properties. The 3% Ho-doped ZnO material is expected to be a promising candidate for the trace detection of n-propanol gas.

2.
Chem Commun (Camb) ; 58(55): 7682-7685, 2022 Jul 07.
Artigo em Inglês | MEDLINE | ID: mdl-35730446

RESUMO

The addition of an extra metal source induces the transformation from crystalline α-Ni(OH)2 to an amorphous NiCoFeCrMo-based high-entropy hydroxide (HEH) and maximizes the high-valence Ni3+ content in HEH. For OER electrocatalysis, the quinary HEH possesses an overpotential of 292 mV at 10 mA cm-2, a Tafel slope of 54.31 mV dec-1 and the boosted intrinsic activity, surpassing other subsystems.

3.
Chem Asian J ; 17(16): e202200392, 2022 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-35621703

RESUMO

Metal-organic frameworks are often used as a chemotherapeutic drug carrier due to their diverse metal sites and good acid degradation ability. Herein Co-doped Zn-MOF-5 nanoparticles with a high Co doping rate of 60% were synthesized for chemo-chemodynamic synergistic therapy of tumor. Co ions can mediate chemodynamic therapy through Fenton-like reaction and regulate the tumor microenvironment by consuming the reduced glutathione. The CoZn-MOF-5 shows high drug loading capacity with doxorubicin loading rate of 72.8%. The CoZn-MOF-5@PEG@DOX nanodrugs has a strong killing effect on 4T1 cancer cells, suggesting the chemo-chemodynamic synergistic effect on tumor therapy.


Assuntos
Nanopartículas , Neoplasias , Linhagem Celular Tumoral , Cobalto/farmacologia , Doxorrubicina/metabolismo , Doxorrubicina/farmacologia , Doxorrubicina/uso terapêutico , Humanos , Neoplasias/patologia , Microambiente Tumoral , Zinco/farmacologia
4.
Chem Commun (Camb) ; 57(24): 3022-3025, 2021 Mar 25.
Artigo em Inglês | MEDLINE | ID: mdl-33624652

RESUMO

Herein, small Co nanoparticles (NPs) encapsulated in N-doped double-shelled carbon nanocages grafted with thin carbon nanotubes (Co@CNTs@DSCNCs) were synthesized from yolk-shell bimetallic zeolitic imidazolate framework (BMZIF). For HER electrocatalysis, they exhibit higher activity (η10 = 214 mV) and more favorable kinetics than Co@CNTs@PC (PC = porous carbon) with thick CNTs and large Co NPs derived from solid BMZIF cubes.

5.
BMC Pulm Med ; 20(1): 37, 2020 Feb 11.
Artigo em Inglês | MEDLINE | ID: mdl-32046709

RESUMO

BACKGROUND: Prolonged and difficult weaning is associated with higher rates of complications and mortality. Therefore, it is important to identify the associated factors. CASE PRESENTATION: We describe our experience with a 37-year-old man diagnosed with severe viral pneumonia (influenza A). He presented with acute respiratory failure type I on admission. During intubation, his blood pressure and heart rate decreased, and epinephrine and norepinephrine were administered. Although his clinical condition improved 8 days after intensive care unit (ICU) admission, he experienced difficulty weaning. He remained conscious but had a poor spontaneous cough with sputum production and weak limb muscle strength. His cough reflex was absent during bronchoscopic sputum suction, and he used abdominal breathing during the T-tube test. Magnetic resonance imaging revealed an Arnold-Chiari malformation type I, posterior dislocation of the odontoid process, and syringomyelia, with compression and deformation of the medulla and high cervical cord. The patient was successfully weaned from the ventilator at 20 days after ICU admission. CONCLUSIONS: Arnold-Chiari malformation type I and posterior dislocation of the odontoid process, which aggravate medullary compression and increase the risk of cervical nerve injury, might be a rare factor affecting prolonged weaning in critical illness.


Assuntos
Malformação de Arnold-Chiari/fisiopatologia , Processo Odontoide/patologia , Pneumonia Viral/complicações , Desmame do Respirador , Adulto , Malformação de Arnold-Chiari/diagnóstico por imagem , Humanos , Imageamento por Ressonância Magnética , Masculino , Processo Odontoide/diagnóstico por imagem
6.
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue ; 31(7): 842-846, 2019 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-31441407

RESUMO

OBJECTIVE: To observe the damage of high mobility group box 1 (HMGB1) on human umbilical vein endothelial cell (HUVEC) barrier permeability and the protective effect of unfractionated heparin (UFH), and to explore the down-regulated protection effect mechanism of UFH on HMGB1-mediated vascular endothelial cadherin (VE-cadherin) expression. METHODS: The trypsin-digested HUVEC were subcultured in culture flasks. When the cells were grown to 80%, they were randomly divided into four groups: phosphate buffer (PBS) control group (200 µL PBS), recombinant human high mobility group box 1 (rhHMGB1) treatment group (100 µg/L rhHMGB1), UFH control group (10 kU/L UFH), and UFH pretreatment group (10 kU/L UFH+100 µg/L rhHMGB1). The cells in each group were challenged with different reagent for 24 hours, and the activity of endothelial cells was determined by methyl thiazolyl tetrazolium (MTT) colorimetric assay. The permeability of endothelial cells was measured by Transwell method, and the expression and distribution of VE-cadherin was observed by immunofluorescence. The protein expressions of VE-cadherin and phosphorylated p38 mitogen-activated protein kinase (p-p38MAPK) were determined by Western Blot. RESULTS: After treatment with 100 µg/L rhHMGB1 for 24 hours, the activity of endothelial cells was not significantly different from that of the PBS control group (A value: 0.230±0.004 vs. 0.255±0.006, P > 0.05), but the permeability was significantly increased (glucan FD40 fluorescence intensity: 11.05±0.12 vs. 6.34±0.39, P < 0.05). Compared with PBS control group, the fluorescence microscopy showed that the VE-cadherin membrane localization was reduced, the distribution was loose, and there were obvious fissures between cells in rhHMGB1 treatment group, and quantitative analysis showed the protein expression of VE-cadherin was decreased significantly (VE-cadherin/ß-actin: 0.16±0.04 vs. 0.31±0.03, P < 0.05), and the expression of p-p38MAPK protein was significantly increased (p-p38MAPK/ß-actin: 0.79±0.03 vs. 0.26±0.05, P < 0.05). UFH pretreatment could protect HMGB1-mediated endothelial cell injury, cell permeability was significantly reduced (glucan FD40 fluorescence intensity: 9.11±0.23 vs. 11.05±0.12), fluorescence expression of VE-cadherin was enhanced, membrane localization was significantly increased, quantitative analysis showed that VE-cadherin protein expression was significantly up-regulated (VE-cadherin/ß-actin: 0.24±0.02 vs. 0.16±0.04), and p38MAPK phosphorylation level was significantly decreased (p-p38MAPK/ß-actin: 0.54±0.05 vs. 0.79±0.03), the difference was statistically significant as compared with rhHMGB1 treatment group (all P < 0.05). There was no significant difference in all parameters between PBS control group and UFH control group. CONCLUSIONS: UFH can protect the endothelial cell barrier from the HMGB1 by regulating the expression and distribution of VE-cadherin. The mechanism may be related to the inhibition of p38MAPK phosphorylation by UFH.


Assuntos
Caderinas/metabolismo , Fibrinolíticos/uso terapêutico , Proteína HMGB1/metabolismo , Heparina/uso terapêutico , Antígenos CD/metabolismo , Permeabilidade Capilar , Células Cultivadas , Células Endoteliais , Humanos
7.
Biomed Res Int ; 2018: 5086516, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29977913

RESUMO

In sepsis-3, in contrast with sepsis-1, the definition "systemic inflammatory response" has been replaced with "dysregulated host response", and "systemic inflammatory response syndrome" (SIRS) has been replaced with "sequential organ failure assessment" (SOFA). Although the definition of sepsis has changed, the debate regarding its nature is ongoing. What are the fundamental processes controlling sepsis-induced inflammation, immunosuppression, or organ failure? In this review, we discuss the heterogeneity of sepsis-3 and address the central role of inflammation in the pathogenesis of sepsis. An unbalanced pro- and anti-inflammatory response, inflammatory resolution disorder, and persistent inflammation play important roles in the acute and/or chronic phases of sepsis. Moreover, powerful links exist between inflammation and other host responses (such as the neuroendocrine response, coagulation, and immunosuppression). We suggest that a comprehensive evaluation of the role of the inflammatory response will improve our understanding of the heterogeneity of sepsis.


Assuntos
Sepse/imunologia , Síndrome de Resposta Inflamatória Sistêmica/imunologia , Humanos , Terapia de Imunossupressão , Inflamação
8.
Inorg Chem ; 56(22): 13646-13650, 2017 Nov 20.
Artigo em Inglês | MEDLINE | ID: mdl-29094930

RESUMO

Herein, through a morphology-inherited annealing treatment of a hollow Fe-doped MOF-5 octahedron as the self-sacrificing template, we report the synthesis of concave ZnFe2O4 hollow octahedral nanocages as sensing materials, which exhibited high performance, including unprecedented excellent sensitivity, good selectivity, and cyclic stability at ultralow working temperature (120 °C).

9.
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