Squishing sound heard following an intra-articular shoulder injection with fluid and air is associated with higher efficacy: A retrospective analysis.

BACKGROUND: Accuracy of blind intra-articular injections for the shoulder is rather low. It is unclear whether accurate injections for capsulitis of the shoulder are more effective than inaccurate injections. OBJECTIVE: It has been hypothesized that a squishing sound following an intra-articular injection with a mixture of air and fluid means that the injection was accurately placed and that the efficacy of accurately placed injections is greater than that of inaccurate injections. The aim of the present study was to test the hypothesis that a squishing sound following an injection predicts a better clinical result. METHODS: Files were selected of patients with capsulitis of the shoulder, who were treated with an intra-articular injection containing a mixture of triamcinolone, lidocaine, and air. After the injection, the shoulder was moved to determine whether a squishing sound could be produced. Efficacy was measured after two weeks according to the Patient Global Impression of Change scale. Differences in efficacy between injections with and without a squishing sound were expressed as an odds ratio. RESULTS: Sixty-one patients were selected. Squishing was heard after 47 injections (77%). Two weeks after the injection, a positive outcome was reported by 49 patients (80%). When squishing was heard, the effect was positive in 42 of the 47 patients (89%) and when no squishing was heard, the effect was positive in 7 of the 14 patients (50%). The odds ratio was 8.4 (95% CI 2.1-34.0; p= 0.003). CONCLUSION: Efficacy of injections with a mixture of triamcinolone, lidocaine, and air for capsulitis of the shoulder is significantly greater when a squishing sound was heard after the injection. We hypothesize that squishing is related to accuracy and accuracy to efficacy. A future study with X-ray arthrography is needed to verify both hypotheses.

[Is bone marrow edema a cause of low back pain? A possible role of bacteria]. / Is eindplaatoedeem van wervellichamen een oorzaak van lage-rugpijn?

Lumbar bone marrow edema, also known as Modic type-1 endplate change, has a prevalence of 43% in low back pain populations and 6% in general populations. Besides mechanical factors and genetic predisposition it has been hypothesized that lumbar bone marrow edema is caused by a latent infection of low-virulence anaerobic bacteria in degenerated lumbar intervertebral discs. The hypothesis is supported by the observation that the presence of Cutibacterium acnes is more frequently found in samples of disci with Modic-1 than in discs without and by the positive effects of antibiotics in patients with back pain and Modic-1 as shown in placebo-controlled RCT's. Opponents of the hypothesis argue that the findings of bacteria are most likely a result of contamination during harvesting the samples. We conclude that time has come to make a start in the Netherlands with treatment with antibiotics of a small group of well-selected patients in well-selected clinics.

The transverse abdominal muscle is excessively active during active straight leg raising in pregnancy-related posterior pelvic girdle pain: an observational study.

BACKGROUND: Many studies suggest that impairment of motor control is the mechanical component of the pathogenesis of painful disorders in the lumbo-sacral region; however, this theory is still unproven and the results and recommendations for intervention remain questionable. The need for a force to compress both innominate bones against the sacrum is the basis for treatment of pregnancy-related pelvic girdle pain (PGP). Therefore, it is advised to use a pelvic belt and do exercises to enhance contraction of the muscles which provide this compression. However, our clinical experience is that contraction of those muscles appears to be excessive in PGP. Therefore, in patients with long-lasting pregnancy-related posterior PGP, there is a need to investigate the contraction pattern of an important muscle that provides a compressive force, i.e. the transverse abdominal muscle (TrA), during a load transfer test, such as active straight leg raising (ASLR). METHODS: TrA thickness was measured by means of ultrasound imaging at rest and during ASLR in 43 non-pregnant women with ongoing posterior PGP that started during a pregnancy or delivery, and in 39 women of the same age group who had delivered at least once and had no current PGP (healthy controls). RESULTS: In participants with PGP, the median TrA thickness increase with respect to rest during ipsilateral and contralateral ASLR was 31% (SD 46%) and 31% (SD 57%), respectively. In healthy controls, these values were 11% (SD 25%) and 13% (SD 22%), respectively. CONCLUSIONS: Significant excessive contraction of the TrA is present during ASLR in patients with long-lasting pregnancy-related posterior PGP. The present findings do not support the idea that contraction of the TrA is decreased in long-lasting pregnancy-related PGP. This implies that there is no rationale for the prescription of exercises to enhance contraction of TrA in patients with long-lasting pregnancy-related PGP.

The Active Straight Leg Raise test in lumbopelvic pain during pregnancy.

Although many properties of the Active Straight Leg Raise (ASLR) test as a diagnostic test in lumbopelvic pain (LPP) are well documented, various elements are lacking. A cross-sectional study was performed to compute sensitivity and specificity, to assess the advantages and disadvantages of various cutoff points, to analyze the relation between the ASLR test and the Posterior Pelvic Pain Provocation (PPPP) test, and to investigate the relation with confounders. Data of 110 women with LPP and 72 without LPP were available. The advantages and disadvantages of four cutoff points of ASLR, and combinations of the ASLR and PPPP, were investigated by comparing sensitivity, specificity and area under the curves (AUC) of receiver operating characteristic curves (ROC). The influence of the site of pain was analyzed by means of AUC. The relation with confounders was measured using Pearson correlation coefficients. Results show that for diagnostic use the best cutoff for the ASLR test in pregnancy is between score 0 and 1. Specificity of the ASLR test is good (88%). Sensitivity for all types of LPP during pregnancy is moderate (54%), and is larger in case of more pain and disability. When combined with the PPPP test, sensitivity of the ASLR test is larger (68%). Isolated symphyseal pain, isolated low back pain and isolated coccyx pain are not diagnosed by these two tests. The ASLR test is not influenced by age, number of previous deliveries, BMI, cause of LPP (pregnancy-related or not), the existence of urinary incontinence and/or level of fatigue.

Severity of signs and symptoms in lumbopelvic pain during pregnancy.

Data on the severity of signs and symptoms of lumbopelvic pain (LPP) during pregnancy are scarce. Therefore, this cross-sectional study examines the severity of LPP and pain-related signs and symptoms. Women with an uncomplicated pregnancy of 20-30 weeks were invited to participate. They rated their pain and fatigue on a numerical rating scale, and pain location was indicated on a drawing. Disability was scored on the Quebec Back Pain Disability Scale (QBPDS) and urine incontinence on a Likert scale. Physical examination consisted of the Active Straight Leg Raise (ASLR) test, the Posterior Pelvic Pain Provocation (PPPP) test and pain score, and force during isometric bilateral hip adduction. Of all 182 participants, 60.4% reported LPP. Mean pain level was 3.6 (SD 2.2); in 20.0% of the women the score was >5. The mean score on the QBPDS was 27 (SD 16); in 20.9% the score was >40. Compared to women without LPP, women with LPP more frequently suffered back pain in the past (p<0.001), had a higher body mass index (p<0.01), more often had urinary incontinence (p<0.05), had less isometric hip adduction force (p<0.001), had more pain on isometric hip adduction (p<0.01), had a higher ASLR score (p<0.001) and more had often a positive PPPP test (p<0.001). Fatigue was not related to LPP during pregnancy. The main conclusion is that pain and disability of LPP during pregnancy can be interpreted as mild to moderate in most cases, and as severe in about 20%.

The effect of experimental groin pain on abdominal muscle thickness.

OBJECTIVES: It is not clear whether abnormal abdominal muscle behavior in athletes with longstanding groin pain is a risk factor for groin pain or is caused by groin pain itself. Therefore, this study investigated whether anticipation of experimental groin pain influences abdominal muscle behavior. METHODS: In 14 healthy athletes, abdominal muscle thickness was measured using ultrasound under conditions of anticipated groin pain and acute groin pain. Groin pain was induced using superficial electrical skin stimulation. Tasks evaluated were isometric hip adduction and active straight leg raise (ASLR) left. RESULTS: The m. transversus abdominis and m. obliquus internus showed a significant decrease in thickness during "anticipation of pain" compared with "no pain" and "pain" during both hip adduction and ASLR (P values <0.04). For m. obliquus externus, a significant increase in thickness was found only during "pain" compared with "no pain" and "anticipation of pain" for ASLR (P<0.004). DISCUSSION: If ASLR or hip adduction is associated with anticipated groin pain, abdominal muscle behavior is different from a pain-free situation and from a painful situation. These results suggest that abnormal abdominal muscle behavior found in athletes with longstanding groin pain may be caused by a pain anticipatory motor strategy. This may have implications for rehabilitation.

Relation between subjective and objective scores on the active straight leg raising test.

DESIGN: Cross sectional. OBJECTIVE: To fill a gap in the validation of the active straight leg raising (ASLR) test concerning the relation between a patient's subjective score on the ASLR test and the objective measured force. SUMMARY OF BACKGROUND DATA: The ASLR test is used to classify patients presenting with pain in the low back and/or pelvic girdle. Although its reliability and validity have been demonstrated, some details are still lacking. METHODS: The ASLR test was performed by 21 parous women with various ASLR scores. Subjective weakness was scored by the patient both with and without a pelvic belt; moreover the isometric forces of leg raising were measured. RESULTS: The correlation coefficients between the subjective ASLR score and objective measured force at 0 and 20 cm elevation were -0.58 (P < 0.01) and -0.52 (P < 0.05), respectively, at the left side; and -0.45 (P < 0.05) and -0.63 (P < 0.01), respectively, at the right side. When measured with a pelvic belt the correlations were, respectively, -0.51 and -0.48 at the left side, and -0.47 and -0.50 at the right side (all P < 0.05). After applying a pelvic belt the mean subjective ASLR score decreased with 0.38 point at the left side and 0.48 point at the right side (both P < 0.05). With the belt, the measured force at 0 cm elevation increased by 11.6% (P < 0.001) at the left side and by 8.6% (P < 0.05) at the right side; at 20 cm elevation the changes in measured force were negligible. No significant correlation was found between the subjective and the objective changes elicited by the pelvic belt. CONCLUSION: The subjective scores on the ASLR test correlate well with the objective measured forces; this supports the reliability of the ASLR test. The subjective influence of a pelvic belt on the ASLR score could not be objectified.

Mobility of the pelvic joints in pregnancy-related lumbopelvic pain: a systematic review.

About 45% of all pregnant women and 25% of all women postpartum suffer from pelvic girdle pain and/or low back pain (PLPP). It has been suggested that increased motion of the three joints in the pelvic ring is one of the causes of PLPP. However, in spite of the availability of high technology the relation between enlarged motion of the pelvic joints and pain remains unclear. This article presents 14 studies on this topic, of which 8 are of sufficient quality to draw conclusions. The conclusion is that, during the last months of pregnancy and the first 3 weeks after delivery, motion of the pelvic girdle joints is 32-68% larger in patients with PLPP than in healthy controls. The overlap in the range of symphyseal motion between PLPP patients and healthy controls is too large to use motion as a diagnostic tool in individual cases. The findings support the idea that enlarged motion is one of the factors that causes PLPP and justifies treatment with measures to reduce this motion.

The mechanical effect of a pelvic belt in patients with pregnancy-related pelvic pain.

BACKGROUND: Many patients with pregnancy-related pelvic girdle pain experience relief of pain when using a pelvic belt, which makes its use a common part of the therapy, but there is no in vivo proof of the mechanical effect of the application of a pelvic belt. METHODS: The influence of a pelvic belt on sacroiliac joint laxity values was tested in 25 subjects with pregnancy-related pelvic girdle pain by means of Doppler imaging of vibrations in prone position with and without the application of a pelvic belt. The belt was adjusted just below the anterior superior iliac spines (high position) and at the level of the pubic symphysis (low position). FINDINGS: Sacroiliac joint laxity values decreased significantly during both applications of a pelvic belt (P<0.001). The application of a pelvic belt in high position decreased sacroiliac joint laxity to a significantly greater degree than the application of a belt in low position (P=0.006). The decrease of laxity significantly correlated with the decrease of the score on the active straight leg raise test (r=0.57 for the low position, P=0.003 and r=0.54 for the high position, P=0.005). INTERPRETATION: Application of a pelvic belt significantly decreases mobility of the sacroiliac joints. The decrease of mobility is larger with the belt positioned just caudal to the anterior superior iliac spines than at the level of the pubic symphysis. The findings are in line with the biomechanical predictions and might be the basis for clinical studies about the use of pelvic belts in pregnancy-related pelvic girdle pain.

The use of medication in low back pain.

The choice of medication for low back pain should be evidence based and tailored as much as possible to suit the individual patient. Acetaminophen (paracetamol), mild opioids and NSAIDs are the first-line drugs for low back pain but there is no evidence that one is more effective than the others. Non-benzodiazepine muscle relaxants (with or without pain medication) could be considered as second-line drugs in acute low back pain, and cyclic antidepressants in chronic low back pain. The risk of adverse side effects can be reduced by taking account of the patient's medical history and by using a test dose. The realization that symptoms other than pain are sometimes more important and/or easier to overcome can increase the benefits of medication. The long-term effects of medication can be improved when it is combined with non-drug interventions.

Reliability and validity of hip adduction strength to measure disease severity in posterior pelvic pain since pregnancy.

STUDY DESIGN: A cross-sectional analysis was performed in patients with posterior pelvic pain since pregnancy (PPPP). The strength of adduction of the hips was measured and compared with the scores of commonly used disease severity measures of lumbopelvic pain. OBJECTIVES: To assess the reliability and validity of using hip adduction strength as measure of disease severity in patients with PPPP. SUMMARY OF BACKGROUND DATA: Various tools are used to measure disease severity in PPPP; there is still a need for simple tests with high reliability and validity. METHODS: Intra- and intertester reliability of hip adduction strength measurement was assessed in two small groups of women with PPPP. Validity of hip adduction strength to measure disease severity was investigated in a group of 200 patients with PPPP by comparing the test scores with the medical history, scores on self-reported scales on disability, pain, and tiredness, pain provocation tests, and the active straight leg raise test. Responsiveness of hip adduction strength was assessed in a group of 75 patients with PPPP. Global impression of improvement, scored by the patient, was used as criterion standard. The responsiveness of the hip adduction strength was expressed as the standardized response mean and was compared with the responsiveness of the Quebec Back Pain Disability Scale. RESULTS: The intratester reliability for measuring hip adduction strength and the intraclass correlation coefficient were both 0.79. The intertester reliability for measurement of adduction strength and the intraclass correlation coefficient were also both 0.79. Hip adduction strength correlated as expected with all disease severity measures. Responsiveness of the hip adduction strength was large (standardized response mean = 0.93) and slightly less than that of the Quebec Back Pain Disability Scale (standardized response mean = 1.20). CONCLUSION: Hip adduction strength can be recommended to measure disease severity in PPPP, especially to describe groups of patients and to evaluate the course of the disease in groups as well as in individual patients. Decreased hip adduction strength appears to be caused by the inability to use the hip muscles rather than by weakness of the muscles.

Possible role of the long dorsal sacroiliac ligament in women with peripartum pelvic pain.

BACKGROUND: To enhance the understanding of the pathophysiology of women with peripartum pelvic pain, it is necessary to couple anatomical insights with relevant clinical research. In this context, the long dorsal sacroiliac ligament is especially of interest because it was noticed that women diagnosed with peripartum pelvic pain frequently experience pain within the boundaries of this ligament. Njoo (1) found a high intertester reliability and a high specificity for long dorsal sacroiliac ligament pain. The present article focuses on the possible role of the long dorsal sacroiliac ligament in the pain pattern of women with peripartum pelvic pain. The diagnostic and therapeutic consequences are considered. STUDY DESIGN: A cross-sectional analysis was performed in a homogenous group of women meeting strict criteria for posterior pelvic pain since pregnancy, diagnosed as having peripartum pelvic pain and excluded for any history of fracture, neoplasm or previous surgery of the lumbar spine, the pelvic girdle, the hip joint or the femur. The patients were also excluded for signs indicating radiculopathy: asymmetric Achilles tendon reflex and/or (passive) straight leg raising restricted by pain in the lower leg. METHODS: The study group comprised 178 women diagnosed with peripartum pelvic pain, selected from the outpatient clinic of a specialized rehabilitation center. Selection was based on criteria enabling a strict division between lumbar and pelvic complaints. Pain in the long dorsal sacroiliac ligament was detected by standardized palpation of the long dorsal sacroiliac ligament by specifically trained physicians and scored on a modified scale. Comparisons with the posterior pelvic pain provocation test and the active straight leg raise test was carried out. RESULTS: The present study confirms that the long dorsal sacroiliac ligament frequently shows tenderness on palpation in patients with peripartum pelvic pain. Sensitivity was 76%. Sensitivity in a group of 133 women of the study group that scored positive on both active straight leg raise and posterior pelvic pain provocation tests was 86%. When only severe pelvic patients were included, sensitivity increased to 98%. In comparisons between the posterior pelvic pain provocation and the long dorsal sacroiliac ligament tests on the left and right side, Pearson's correlation coefficient was 0.33 and 0.41, respectively. In comparisons between the active straight leg raise and the long dorsal sacroiliac ligament tests on the left and right side, Pearson's correlation coefficient was 0.35 and 0.41, respectively. CONCLUSIONS: The present study, carried out on a group of peripartum pelvic pain patients with strict in- and exclusion criteria, attempts to further elucidate the pathophysiology of patients with peripartum pelvic pain by adding a simple pain provocation test. It is concluded that the combination of the active straight leg raise, the posterior pelvic pain provocation and the long dorsal sacroiliac ligament pain tests combined with the proposed in- and exclusion criteria seems promising in differentiating between mainly lumbar and pelvic complaints. Although the sensitivity of the long dorsal sacroiliac ligament pain test seems promising, further clinical study is necessary in targeting specifically the long dorsal sacroiliac ligament. It is suggested that studies initiated to show the prevalence of sacroiliac joint pain in patients presenting nonspecific lumbopelvic pain, by using intra-articularly double block injection techniques, should include a peripheral injection of at least the long dorsal sacroiliac ligament.

Responsiveness of outcome measurements in rehabilitation of patients with posterior pelvic pain since pregnancy.

STUDY DESIGN: A cohort study was conducted. OBJECTIVE: To develop a test battery for evaluating the course of posterior pelvic pain since pregnancy. SUMMARY OF BACKGROUND DATA: Properly validated scales to evaluate the course of posterior pelvic pain since pregnancy are scarce. Moreover, the use of many tests would be too strenuous for the patient and has an unfavorable cost-benefit ratio. METHODS: The ability of 48 effect measures to detect clinically relevant changes over time (responsiveness) was tested in patients with posterior pelvic pain since pregnancy. In this test, 35 measures were evaluated in a group of 44 patients, and 16 measures in a group of 56 patients (three measures were evaluated in both groups). All the tests were performed at baseline and after 8 weeks treatment. A global impression of improvement (improved or not improved) scored by the patient was used as the standard for assessing the course of the disease. Responsiveness was examined by calculating the standardized response mean of the improved patients and by using a two-tailed Mann-Whitney nonparametric test to compare the patients who had improved and those who had not improved. RESULTS: Of the 48 effect measures, 26 measures of five categories (activities of daily living, pain, hip muscle strength, spine mobility, and spine muscle strength) showed good correlation with the patient's global impression of improvement. The measures in the "mobility of the pelvic joints" category were insufficient for assessing clinical change in posterior pelvic pain since pregnancy. The measures in the "fatigue" and "pain provocation tests" categories correlated only moderately with clinical change. CONCLUSIONS: It seems possible to gain appropriate information about the course of posterior pelvic pain since pregnancy with a small test battery. The usefulness of the Québec Back Pain Disability Scale, the hip adduction strength assessment, and the active straight-leg-raise test was proved by the current study. The value of 23 other instruments was substantiated, but further studies are needed to confirm their usefulness. The correlation of 22 evaluated measures with the patient's global improvement was too weak for them to be recommended as measures of clinical changes over time in posterior pelvic pain since pregnancy. It is recommended that clinicians and investigators compile a small test battery by selecting the best representatives of the five measurement categories that have good correlation with the patient's global impression of improvement.

Validity of the active straight leg raise test for measuring disease severity in patients with posterior pelvic pain after pregnancy.

STUDY DESIGN: A cross-sectional analysis was performed with a group of women meeting strict criteria for posterior pelvic pain after pregnancy. The active straight leg raise test and common severity measurement scales of lumbopelvic pain were scored. OBJECTIVE: To assess the validity of the active straight leg raise test as a disease severity scale for patients with posterior pelvic pain after pregnancy. SUMMARY OF BACKGROUND DATA: Various diagnostic tools are used to measure disease severity in patients with posterior pelvic pain after pregnancy, but simple tests with high reliability and validity still are needed. METHODS: The investigation was performed with 200 women who had posterior pelvic pain after pregnancy. The validity of the active straight leg raise test as a severity scale was investigated by comparing the test score with the medical history, scores on self-reported disability scales, pain and tiredness, and pain provocation tests. The usefulness of the active straight leg raise test as a severity scale was compared with that of the Québec Back Pain Disability Scale. The influence of several demographic and anthropometric variables on the active straight leg raise score was investigated. RESULTS: The active straight leg raise score ranged from 0 to 10 and correlated as expected with all severity scales. The correlation between the scores on the active straight leg raise test and the Québec Back Pain Disability Scale was 0.70. No association was found between the active straight leg raise score and age, parity, duration of the postpartum period, height, or weight. CONCLUSION: The active straight leg raise test can be recommended as a disease severity scale for patients with posterior pelvic pain after pregnancy.

Efficacy of epidural steroid injections for low-back pain and sciatica: a systematic review of randomized clinical trials.

The purpose of the study was to assess the efficacy of epidural steroid injections for low-back pain. Data was obtained using computer-aided search of published randomized clinical trials and assessment of the methods of the studies. Twelve randomized clinical trials evaluating epidural steroid injections were identified. Data was extracted based on scores for quality of the methods, using 4 categories (study population, interventions, effect measurement, and data presentation and analysis) and the conclusion of the author(s) with regard to the efficacy of epidural steroid injections. Method scores of the trials ranged from 17 to 72 points (maximum 100 points). Eight trials showed method scores of 50 points or more. Of the 4 best studies (> 60 points), 2 reported positive outcomes and 2 reported negative results. Overall, 6 studies indicated that the epidural steroid injection was more effective than the reference treatment and 6 reported it to be no better or worse than the reference treatment. There appeared to be no relationship between the methodological quality of the trials and reported outcomes. In conclusion, there are flaws in the design of most studies. The best studies showed inconsistent results of epidural steroid injections. The efficacy of epidural steroid injections has not been established. The benefits of epidural steroid injections, if any, seem to be of short duration only. Future research efforts are warranted, but more attention should be paid to the methods of the trials.