[Physicochemical and biological properties of human placental amniotic interferon]. / Izuchenie fiziko-khimicheskikh i biologicheskikh svoistv chelovecheskogo platsentarnogo amnioticheskogo interferona.

The possibility of generating large quantities of highly active interferon from human placenta amniotic membrane (plaferon) has been demonstrated. Plaferon is innocuous and nonreactogenic in experimental models and has an antiviral effect of wide spectrum. The activity is resistant to DNase, RNase, lipase, and stable at pH 2. A polyclonal serum to human leukocyte interferon and monoclonal NK-2 antibody did not inhibit the antiviral activity of plaferon. The level of hormones in plaferon and leukocyte interferon preparations was practically similar. In diploid cultures of human fibroblasts the antiviral condition under the effect of plaferon developed slower than under the effect of leukocyte interferon.

[Comparative study of the antiproliferative action of placental interferons]. / Sravnitel'noe izuchenie antiproliferativnogo deistviia platsentarnykh interferonov.

The antiproliferative activity of placenta interferons (amniotic, chorional) prepared at the Institute of Experimental Morphology, Academy of Sciences of the Georgian SSR, was studied. Amniotic interferon was found to be most active in tumor cell cultures of human origin. Placenta interferons showed lower antiproliferative activity in continuous monkey and hamster kidney cell cultures and primary human embryo fibroblast cultures.