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1.
Neuroscience ; 267: 286-306, 2014 May 16.
Artigo em Inglês | MEDLINE | ID: mdl-24583040

RESUMO

Although extensively investigated in socio-cognitive neuroscience, empathy is difficult to study. The first difficulty originates in its multifaceted nature. According to the multidimensional model, empathy combines emotional, automatic (simulation), cognitive (mentalizing) and regulatory (executive functions) processes. Substantial functional magnetic resonance imaging (fMRI) data demonstrated that co-activations in the mirror neuron system (MNS) and mentalizing network (MENT) sustain this co-recruitment of so-called first- and second-person-like processes. Because of the poor temporal resolution of fMRI techniques, we currently lack evidence about the precise timing of the MNS-MENT combination. An important challenge is, thus, to disentangle how MNS and MENT dynamically work together along time in empathy. Moreover, the role of the executive functions in the MNS-MENT combination time course is still unknown. Second, empathy - feeling into - is closely related to sympathy - feeling with - and both phenomena are often conflated in experimental studies on intersubjectivity. In this electrical neuroimaging (EEG) pilot-study, we tested whether the egocentered vs. heterocentered visuo-spatial mechanisms respectively associated with sympathy and empathy differentially modulate the dynamic combination of the MNS-MENT activations in their respective neural time course. For that, we employed our newly developed behavioral paradigm assessing the visuo-spatial - but not emotional - features of empathy and sympathy. Using a data-driven approach, we report that empathy and sympathy are underlied by sequential activations in the MNS from the insula to the inferior frontal gyrus (IFG) between 63ms and 424ms. However, at 333-424ms, empathy triggered greater co-activations in the right IFG and dorsolateral prefrontal cortex (dlPFC) (executive functions). Linking together our present and prior (Thirioux et al., 2010) findings from the same dataset, we suggest that this greater recruitment of the right dlPFC monitors the shift from egocentered and first-person-like mechanisms in the MNS to heterocentered and second-person-like mechanisms in the left temporo-parietal junction within the MENT, i.e., reflecting the onset of perspective-change processes in the neural time course of empathy. Contrasting with sympathy, this recruitment of the executive functions could modulate the output end of the mirroring processing in the premotor and sensorimotor cortices.


Assuntos
Mapeamento Encefálico , Encéfalo/fisiologia , Cognição/fisiologia , Emoções/fisiologia , Empatia/fisiologia , Relações Interpessoais , Adulto , Eletroencefalografia , Feminino , Voluntários Saudáveis , Humanos , Masculino , Neuroimagem , Estimulação Luminosa , Desempenho Psicomotor , Adulto Jovem
2.
Neuroimage ; 69: 126-37, 2013 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-23186917

RESUMO

Functional networks are comprised of neuronal ensembles bound through synchronization across multiple intrinsic oscillatory frequencies. Various coupled interactions between brain oscillators have been described (e.g., phase-amplitude coupling), but with little evidence that these interactions actually influence perceptual sensitivity. Here, electroencephalographic (EEG) recordings were made during a sustained-attention task to demonstrate that cross-frequency coupling has significant consequences for perceptual outcomes (i.e., whether participants detect a near-threshold visual target). The data reveal that phase-detection relationships at higher frequencies are dependent on the phase of lower frequencies, such that higher frequencies alternate between periods when their phase is either strongly or weakly predictive of visual-target detection. Moreover, the specific higher frequencies and scalp topographies linked to visual-target detection also alternate as a function of lower-frequency phase. Cross-frequency coupling between lower (i.e., delta and theta) and higher frequencies (e.g., low- and high-beta) thus results in dramatic fluctuations of visual-target detection.


Assuntos
Encéfalo/fisiologia , Vias Neurais/fisiologia , Percepção Visual/fisiologia , Adulto , Mapeamento Encefálico , Eletroencefalografia , Feminino , Humanos , Masculino , Estimulação Luminosa , Processamento de Sinais Assistido por Computador
3.
Phytopathology ; 101(9): 1061-73, 2011 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-21486143

RESUMO

Phytophthora capsici Leonian is a destructive soilborne pathogen that infects economically important solanaceous, cucurbitaceous, fabaceous, and other crops in the United States and worldwide. The objective of this study was to investigate the genetic structure of 255 P. capsici isolates assigned to predefined host, geographical, mefenoxam-sensitivity, and mating-type categories. Isolates from six continents, 21 countries, 19 U.S. states, and 26 host species were genotyped for four mitochondrial and six nuclear loci. Bayesian clustering revealed some population structure by host, geographic origin, and mefenoxam sensitivity, with some clusters occurring more or less frequently in particular categories. Bayesian clustering, split networks, and statistical parsimony genealogies also detected the presence of non-P. capsici individuals in our sample corresponding to P. tropicalis (n = 9) and isolates of a distinct cluster closely related to P. capsici and P. tropicalis (n = 10). Our findings of genetic structuring in P. capsici populations highlight the importance of including isolates from all detected clusters that represent the genetic variation in P. capsici for development of diagnostic tools, fungicides, and host resistance. The population structure detected will also impact the design and interpretation of association studies in P. capsici. This study provides an initial map of global population structure of P. capsici but continued genotyping of isolates will be necessary to expand our knowledge of genetic variation in this important plant pathogen.


Assuntos
Estruturas Genéticas/genética , Phytophthora/classificação , Phytophthora/genética , Doenças das Plantas/microbiologia , Recombinação Genética/genética , Alanina/análogos & derivados , Alanina/farmacologia , Sequência de Bases , Teorema de Bayes , Núcleo Celular/genética , Análise por Conglomerados , DNA Mitocondrial/química , DNA Mitocondrial/genética , Marcadores Genéticos , Variação Genética , Genótipo , Haplótipos , Especificidade de Hospedeiro , Fator de Acasalamento , Dados de Sequência Molecular , Peptídeos , Filogeografia , Phytophthora/efeitos dos fármacos , Polimorfismo Genético , Análise de Sequência de DNA , Especificidade da Espécie
4.
Neuroscience ; 181: 134-49, 2011 May 05.
Artigo em Inglês | MEDLINE | ID: mdl-21315805

RESUMO

Constructing and updating an internal model of verticality is fundamental for maintaining an erect posture and facilitating visuo-spatial processing. The judgment of the visual vertical (VV) has been intensively studied in psychophysical investigations and relies mainly on the integration of visual and vestibular signals, although a contribution of postural and somatosensory signals has been reported. Here we used high-density 192-channel evoked potential (EP) mapping and distributed source localization techniques to reveal the neural mechanisms of VV judgments. VV judgments (judging the orientation of visual lines with respect to the subjective vertical) were performed with and without a tilted visual frame. EP mapping revealed a sequence of neural processing steps (EP maps) of which two were specific for VV judgments. An early EP map, observed at ∼75-105 ms post-stimulus, was localized in right lateral temporo-occipital cortex. A later EP map (∼260-290 ms) was localized in bilateral temporo-occipital and parieto-occipital cortex. These data suggest that early VV-related neural processing involves the lateral and ventral visual stream and is related to visual processing concerning orientation, attention and comparison. The later, more dorsal, activation involves multimodal cortex subtending a constantly available and updated internal model of the vertical that we can refer to for the control of one's posture, actions, and visuo-spatial processing.


Assuntos
Córtex Cerebral/fisiologia , Potenciais Evocados Visuais/fisiologia , Julgamento/fisiologia , Orientação/fisiologia , Tempo de Reação/fisiologia , Percepção Visual/fisiologia , Adulto , Córtex Cerebral/anatomia & histologia , Feminino , Humanos , Masculino , Adulto Jovem
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