1.
J Med Chem
; 29(4): 448-53, 1986 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-3959024
RESUMO
Derivatives of the antifibrinolytic drug tranexamic acid [trans-4-(aminomethyl)cyclohexanecarboxylic acid] containing one or two tranexamic acid moieties were synthesized. Most of the derivatives have good stability in acidic and neutral solutions but are easily hydrolyzed in plasma. By measuring the amount of tranexamic acid excreted in the urine after an oral dose, relative absorptions of a number of derivatives in the rat were estimated. Most of the derivatives showed greater absorption than tranexamic acid itself. 1-[(Ethoxycarbonyl)oxy]ethyl trans-4-(amino-methyl)cyclohexanecarboxylate hydrochloride was chosen for studies in man.
Assuntos
Ácidos Cicloexanocarboxílicos/síntese química , Ácido Tranexâmico/síntese química , Animais , Absorção Intestinal , Masculino , Ratos , Ratos Endogâmicos , Relação Estrutura-Atividade , Ácido Tranexâmico/análogos & derivados , Ácido Tranexâmico/metabolismo
2.
Acta Pharm Suec
; 16(3): 173-86, 1979.
Artigo
em Inglês
| MEDLINE
| ID: mdl-484250
3.
Acta Pharm Suec
; 15(6): 406-18, 1978.
Artigo
em Inglês
| MEDLINE
| ID: mdl-749545