RESUMO
PURPOSE: To evaluate in men with type 2 diabetes the association of cardiometabolic indices [Visceral Adiposity Index (VAI), Triglyceride Glucose Index (TyG), and lipid accumulation product (LAP)] with total testosterone (TT) levels, and their predictive cut-off values in identifying hypogonadism. METHODS: 265 consecutive men aged 40-70 years with type 2 diabetes performed an andrological evaluation; metabolic parameters and TT were determined. Receiver operating characteristic (ROC) curves were used to identify cut-off values of cardiometabolic indices in predicting low testosterone (TT < 12 nmol/l). RESULTS: VAI, TyG, and LAP were negatively associated with TT levels. The prevalence of hypogonadism in men in the fourth quartiles of VAI, TyG, and LAP was ~ 70.0-75.0% compared to ~ 10.0-17.0% in men in the first quartiles (p < 0.001). The sensitivity and specificity of the three cardiometabolic indices in predicting TT < 12 nmol/l were significantly higher concerning BMI, waist circumference, lipid profile and HbA1c. Cut off values of VAI ≥ 3.985, TyG ≥ 4.925, and LAP ≥ 51.645 predict hypogonadism with good sensitivity and specificity. CONCLUSION: This is the first study evaluating the association of VAI, TyG, and LAP with hypogonadism in men with type 2 diabetes. Alterations in these indices should direct the patients to andrological evaluation.
Assuntos
Doenças Cardiovasculares , Diabetes Mellitus Tipo 2 , Hipogonadismo , Humanos , Masculino , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/epidemiologia , Circunferência da Cintura , Glucose , Triglicerídeos/metabolismo , Hipogonadismo/diagnóstico , Hipogonadismo/epidemiologia , Hipogonadismo/etiologia , Obesidade Abdominal/complicações , Adiposidade , Índice de Massa Corporal , Doenças Cardiovasculares/complicações , TestosteronaAssuntos
Anemia Hemolítica Autoimune/tratamento farmacológico , Colite Ulcerativa/tratamento farmacológico , Ciclosporinas/uso terapêutico , Fluocortolona/uso terapêutico , Doença Aguda , Adulto , Anemia Hemolítica Autoimune/etiologia , Colite Ulcerativa/complicações , Avaliação de Medicamentos , Quimioterapia Combinada , Feminino , Humanos , RecidivaRESUMO
The short and long-term efficacy of the combined administration of azathioprine and sulphasalazine in the treatment of ulcerative colitis was evaluated. A complete and durable remission of the clinical, the endoscopic and the histological signs of the disease was achieved in all the patients but one, who did not follow the domiciliary therapeutic regimen. No adverse effects referable to the long-term assumption of the azathioprine have been noted.
