RESUMO
Effects of acute lethal blood loss on postresuscitation heart impairment has been studied. Experiments were performed in mongrel male rats anesthesized with sodium pentobarbital (25 mg/kg). Functional metabolic heart impairments have been evaluated in different terms after resuscitation by isolated perfused heart method (Fallen et al., J. Appl. Physiol, 22 (1967) 836-839). It has been established that maximal heart injury occurs in the first hours after resuscitation. It is supported by the following findings: depression of myocardium contractile function grew; enzyme excretion from cardiomyocytes in coronary flow increased: efficacy of glucose utilization by means of carried function decreased; pyruvate excretion in coronary flow elevated. Because of severe course of postresuscitation period functional metabolic heart disturbances are more pronounced and preserved for a long time.
