[Isolation of Nocardia asteroides using hemoculture (clinical report)]. / Izolace Nocardia asteroides z hemokultury (sdelení z praxe).

The authors describe the finding of Nocardia asteroides from a haemoculture in a patient with right-sided pneumonia and several predisposing factors (TB, chronic bronchitis, anamnestic hepatitis, chronic hepatopathy, anaemia, ethylism and a neoplasm revealed in the final stage). Early bacteriological diagnosis and aimed antimicrobial therapy led to radical improvement of the very dramatic clinical condition. The authors discuss the possible higher incidence of the infectious agent, which previously was detected only very rarely.

[Manifestations and early course of type I diabetes mellitus--a decisive period from the viewpoint of controlling the further development of the disease]. / Manifestace a casný prubeh diabetes mellitus I. typu--rozhodující období z hlediska moznosti ovlivnení dalsího vývoje onemocnení.

The autoimmune process focused on B-cells of the islets of Langerhans and leading gradually to their destruction is latent before the manifestation of diabetic symptoms. The detection of this preclinical stage in particular in sporadic cases is in common clinical practice, due to the low prevalence of the disease in the population and pretentious character as regards applied methods, unreal. Therefore attention is focused on the period of clinical manifestation of the diabetic syndrome and its early stages when by early diagnosis and intensive insulin or immunosuppressive treatment it is still possible to preserve a substantial proportion of functional B-cells and influence in an effective manner the onset and duration of remission. The authors summarize experience assembled during the eighties, incl. therapeutic procedures and problems of active immunomodulation in the prehyperglycaemic stage of the disease.