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1.
J Agric Saf Health ; 20(3): 211-8, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-25174152

RESUMO

There are limited data about the incidence and prevalence of musculoskeletal disorders (MSDs) among loggers in the southern U.S. despite the risk factors associated with these occupations. Risk factors are both personal (age, body mass index, etc.) and job-related (awkward postures, repetitive hand and foot movements, vibration, etc.). A survey was conducted to estimate the incidence of self-reported pain and diagnosed MSDs and to study the relationship with known risk factors. Respondents were loggers attending training and continuing education classes. Respondents were asked to identify personal attributes, machine use, awkward postures, repetitive movements, and recent incidence of pain and medical diagnoses. All were male with an average age of 44 (range of 19-67) and an average body mass index of 31.3. Most were machine operators (97%) who have worked in the logging industry for an average of 22.9 years. Most machines identified were manufactured within the past ten years (average machine age 6.7 years). For machine operators, 10.5% (16) reported an MSD diagnosis, 74.3% (113) reported at least mild back pain, and 71.7% (109) reported at least mild neck pain over the past year. Further analysis attempted to identify an association between personal attributes, machine use, posture, and pain. Risk factors related to machine use may be biased since most survey respondents had considerable choice or control in working conditions, as they were firm owners and/or supervisors.


Assuntos
Dor nas Costas/epidemiologia , Agricultura Florestal , Doenças Musculoesqueléticas/epidemiologia , Cervicalgia/epidemiologia , Doenças Profissionais/epidemiologia , Saúde Ocupacional/estatística & dados numéricos , Adulto , Idoso , Dor nas Costas/etiologia , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Doenças Musculoesqueléticas/etiologia , Cervicalgia/etiologia , Doenças Profissionais/etiologia , Prevalência , Fatores de Risco , Autorrelato , Sudeste dos Estados Unidos/epidemiologia , Inquéritos e Questionários , Tennessee/epidemiologia , Adulto Jovem
2.
JACC Cardiovasc Interv ; 2(6): 561-7, 2009 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-19539262

RESUMO

OBJECTIVES: We sought to assess the prevalence of secondary right-to-left circulatory shunt (RLS) in patients undergoing transcatheter closure of patent foramen ovale (PFO) as detected by power M-mode transcranial Doppler (TCD) and intracardiac echocardiography. BACKGROUND: Prevalence of residual RLS in late follow-up after PFO closure may be as high as 34%. Other cardiac and noncardiac sources of RLS may coexist and obscure PFO closure evaluation. METHODS: Eighty-eight patients who underwent transcatheter PFO closure to prevent recurrent paradoxical cerebral embolism between June 2005 and December 2006 were evaluated for a secondary source of RLS. Before device deployment, a sizing balloon was inflated in the PFO tunnel and agitated saline contrast was injected into the inferior vena cava. Clinically significant secondary RLS was defined as >10 embolic tracks on TCD at rest or immediately after calibrated (40 mm Hg), sustained (10 s) respiratory strain, with corresponding negative color-flow Doppler. Late residual RLS was evaluated in all patients with TCD and transthoracic echocardiography (mean: 192 days; 95% confidence interval [CI]: 161 to 223 days). RESULTS: The sample (n = 84) was 59% female, age 49 +/- 14 years. Seventeen patients (20%; 95% CI: 11.7 to 28.8) had secondary RLS during balloon occlusion. At late follow-up (n = 66), 13 of 14 (93%) patients with secondary RLS and 23 of 52 (44%) patients without secondary RLS had residual RLS (p = 0.002). CONCLUSIONS: This is the first report to systematically assess the prevalence of secondary RLS in patients undergoing PFO closure. Residual RLS detected by TCD may be due to secondary RLS, which may have implications for clinical outcomes.


Assuntos
Oclusão com Balão , Circulação Sanguínea , Embolia Paradoxal/diagnóstico por imagem , Forame Oval Patente/diagnóstico por imagem , Embolia Intracraniana/diagnóstico por imagem , Ultrassonografia Doppler em Cores , Ultrassonografia Doppler Transcraniana , Adulto , Oclusão com Balão/instrumentação , Meios de Contraste/administração & dosagem , Embolia Paradoxal/etiologia , Embolia Paradoxal/fisiopatologia , Embolia Paradoxal/prevenção & controle , Feminino , Forame Oval Patente/complicações , Forame Oval Patente/fisiopatologia , Forame Oval Patente/terapia , Humanos , Injeções Intravenosas , Embolia Intracraniana/etiologia , Embolia Intracraniana/fisiopatologia , Embolia Intracraniana/prevenção & controle , Masculino , Pessoa de Meia-Idade , Projetos Piloto , Valor Preditivo dos Testes , Estudos Prospectivos , Prevenção Secundária , Fatores de Tempo , Resultado do Tratamento , Veia Cava Inferior
3.
J Neuroimaging ; 19(3): 235-41, 2009 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-18826441

RESUMO

BACKGROUND AND PURPOSE: Comparison was performed between unilateral and bilateral power M-mode transcranial Doppler to detect right-to-left circulatory shunt (RLS). METHODS: Recorded Doppler data from 87 patients with confirmed RLS referred for transcatheter closure of patent foramen ovale were reanalyzed for embolic tracks (ET) counted from left and right temporal bone windows during bubble study. Unilateral counts were obtained by multiplying each side by 2; bilateral counts were obtained by summing left and right ET. Both unilateral and bilateral ET were converted to a 6-point logarithmic grade. Sex and age group subanalyses were performed. RESULTS: At rest, significantly more ET were detected with bilateral versus unilateral detection (P= .01), but not following Valsalva (P= .13). Unilateral and bilateral detection were equally able to detect large RLS (grades IV or V) following Valsalva (P= 1.00). For the group aged > or =55 years, the right-hand side yielded greater ET than the left-hand side (mean difference 9%+/- 37; 95% confidence interval -3 to 21%) at rest (P= .01), but not following Valsalva (mean difference 1%+/- 25; 95% confidence interval -7 to 9%, P= .10). CONCLUSIONS: Unilateral detection of ET by power M-mode transcranial Doppler is equivalent to bilateral detection to assess RLS.


Assuntos
Doenças Arteriais Cerebrais/diagnóstico por imagem , Artéria Cerebral Média/diagnóstico por imagem , Fatores Etários , Circulação Cerebrovascular , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Reprodutibilidade dos Testes , Estudos Retrospectivos , Fatores Sexuais , Osso Temporal , Ultrassonografia Doppler Transcraniana
4.
Am J Cardiol ; 102(7): 916-20, 2008 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-18805122

RESUMO

Retrospective studies have shown improvement in migraines after patent foramen ovale (PFO) closure. To date, no study has evaluated whether the completeness of closure affects headache status; therefore, the objective of this study was to evaluate the impact of residual right-to-left shunt (RLS) on migraine symptoms after transcatheter PFO closure in migraineurs with and without aura. This was a small-series, single-center, retrospective analysis of late follow-up data on 77 patients with presumed paradoxical embolism and migraine who underwent PFO closure for secondary stroke prevention. Power M-mode transcranial Doppler was used to assess RLS at baseline and 6 and 12 months after closure. A standardized migraine questionnaire was administered at baseline and 6, 12, and 24 months after closure. Fifty-five (71%) patients had migraine with aura. Final closure and migraine status were available for 67 patients; 23 (34%) had incomplete PFO closure, defined as 30 embolic tracks detected at final power M-mode transcranial Doppler examination (median 366 days, 95% confidence interval 332 to 474). Migraine relief (> or = 50% reduction in frequency) was independent of closure status (77% complete closure vs 83% incomplete closure, p = 0.76) at late follow-up (540 days, 95% confidence interval 537 to 711). Migraineurs with aura were 4.5 times more likely to experience migraine relief than migraineurs without aura. In conclusion, migraine relief may occur despite residual RLS after transcatheter PFO closure, which may suggest a reduction in RLS burden below a neuronal threshold that triggers migraine; however, this warrants further investigation. Migraine with aura may be an independent predictor of relief after PFO closure.


Assuntos
Forame Oval Patente/cirurgia , Transtornos de Enxaqueca/prevenção & controle , Acidente Vascular Cerebral/prevenção & controle , Cateterismo Cardíaco , Ecocardiografia , Feminino , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Transtornos de Enxaqueca/diagnóstico por imagem , Sistema de Registros , Estudos Retrospectivos , Estatísticas não Paramétricas , Resultado do Tratamento , Ultrassonografia Doppler Transcraniana
5.
J Headache Pain ; 8(4): 209-16, 2007 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-17901924

RESUMO

The objective of the study was to assess differences in proportion of large right-to-left shunt (RLS) and atrial septal characteristics between migraineurs and non-migraineurs referred for transcatheter closure of patent foramen ovale (PF0). This retrospective study took place in a large metropolitan medical centre. The patients were migraineurs with aura (n=52), migraineurs without aura (n=19) and non-migraineurs (n=149). RLS was evaluated before closure using bilateral power m-mode transcranial Doppler at rest and after calibrated, sustained Valsalva manoeuvre, and graded with a validated 0-5 scale. Intracardiac echocardiography was used to assess atrial septal characteristics. Migraineurs had a higher proportion of large RLS (Grade IV or V) than nonmigraineurs at rest and after calibrated Valsalva (rest, p=0.04; Valsalva, p=0.01). Atrial septal characteristics were similar between groups. Migraine is associated with larger RLS at rest and strain; however migraine status does not predict PFO characteristics.


Assuntos
Septo Interatrial/fisiopatologia , Forame Oval Patente/complicações , Forame Oval Patente/fisiopatologia , Transtornos de Enxaqueca/etiologia , Transtornos de Enxaqueca/fisiopatologia , Fluxo Sanguíneo Regional/fisiologia , Adulto , Idoso , Septo Interatrial/patologia , Encéfalo/irrigação sanguínea , Encéfalo/fisiopatologia , Procedimentos Cirúrgicos Cardíacos , Circulação Cerebrovascular/fisiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Transtornos de Enxaqueca/diagnóstico por imagem , Enxaqueca com Aura/diagnóstico por imagem , Enxaqueca com Aura/etiologia , Enxaqueca com Aura/fisiopatologia , Valor Preditivo dos Testes , Estudos Retrospectivos , Sensibilidade e Especificidade , Resultado do Tratamento , Ultrassonografia Doppler Transcraniana , Manobra de Valsalva/fisiologia
6.
Am J Cardiol ; 99(9): 1312-5, 2007 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-17478164

RESUMO

The purpose of the present study was to assess clinical outcomes and closure status after the transcatheter closure of patent foramen ovale. Two hundred thirty-seven consecutive patients (mean age 53 +/- 15 years; 48% men) who underwent patent foramen ovale closure for the prevention of recurrent stroke were evaluated. Primary end points were death, recurrent stroke, and residual right-to-left shunt (RLS). Closure status was monitored at 1, 6, 12, 24, 36, and 48 months after the index procedure by power M-mode transcranial Doppler and was defined by the number of embolic tracks detected after the release of a sustained, calibrated Valsalva maneuver. During a mean follow-up period of 568 +/- 364 days, the cumulative event rate for recurrent stroke (n = 8) was 3.4%, for an estimated event-free survival of 0.94 (SE 0.03). There was a significant difference in the estimated probability of recurrent stroke for patients grouped by age (< or =55 years 1.4% vs >55 years 6.6%, p = 0.03). There were 7 deaths (3.0%), 1 secondary to and 6 unrelated to recurrent strokes, and 3 surgical explantations (1.3%). Event-free survival, defined as freedom from death, stroke, or explantation, was 0.92 (SE 0.02). The magnitude of RLS was significantly less at late follow-up compared with baseline (grade 4.6 +/- 0.7 vs 1.8 +/- 1.6, p <0.001). Complete closure or minimal residual RLS (grade 0 to II) was achieved in 66% of patients. Device type (CardioSEAL or Amplatzer) did not affect the risk for adverse events or the presence of large residual RLS. In conclusion, transcatheter patent foramen ovale closure is associated with a low recurrent stroke rate in long-term follow-up.


Assuntos
Oclusão com Balão , Cateterismo Cardíaco , Embolia Paradoxal/prevenção & controle , Comunicação Interatrial/terapia , Embolia Intracraniana/prevenção & controle , Acidente Vascular Cerebral/prevenção & controle , Adulto , Idoso , Intervalo Livre de Doença , Embolia Paradoxal/etiologia , Feminino , Seguimentos , Comunicação Interatrial/complicações , Humanos , Embolia Intracraniana/etiologia , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Prevenção Secundária , Acidente Vascular Cerebral/etiologia , Resultado do Tratamento
7.
Stroke ; 38(6): 1780-5, 2007 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-17463309

RESUMO

BACKGROUND AND PURPOSE: We hypothesized that direct cervical investigation with Power M-Mode Doppler (PMD) combined with single-gate Doppler spectral analysis (SGDSA) using a 2-MHz pulsed-wave Doppler transducer would show reasonable accuracy parameters when compared with standard color-coded carotid duplex ultrasound (CDU). METHODS: We prospectively screened for cervical internal carotid artery (ICA) stenosis by direct observation using a 2 MHz PMD/SGDSA device. PMD identified the artery (location, depth, flow direction) and SGDSA assessed waveform; peak systolic, end diastolic, and mean flow velocities (MFV) of the common carotid artery; cervical ICA proximally and distally; and external carotid artery. Diagnostic accuracy was compared with concurrent carotid duplex ultrasound. The continuity principle was applied using the proximal/distal cervical ICA MFV ratio. RESULTS: We examined 456 vessels (228 patients). Using ICA proximally/ICA distally MFV ratio of 1.5 or greater or absence of ICA signature, for 40% to 59% or greater stenosis (including occlusions), sensitivity was 75.4%, specificity 99.8%, positive predictive value 97.7%, negative predictive value 96.6%, and accuracy 96.7%. For MFV ratio 1.6 or greater or absence of ICA signature and 60% to 79% or greater stenosis (including occlusions), sensitivity was 92.3%, specificity 98.1%, positive predictive value 81.8%, negative predictive value 99.3%, and accuracy 97.6%. CONCLUSIONS: Use of combined PMD and SGDSA to directly observe the extracranial ICA is reasonably accurate compared with carotid duplex ultrasound. Using the MFV ratio of proximal/distal extracranial ICA improves accuracy parameters and provides a quick and effective bedside screen for ICA stenosis. This novel technique should be considered part of the standard PMD/transcranial Doppler examination.


Assuntos
Artéria Carótida Interna/diagnóstico por imagem , Estenose das Carótidas/diagnóstico por imagem , Ultrassonografia Doppler de Pulso/métodos , Ultrassonografia Doppler Transcraniana/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Sensibilidade e Especificidade , Transdutores
8.
J Fish Dis ; 30(2): 101-9, 2007 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-17298565

RESUMO

The distribution of infectious salmon anaemia (ISA) was examined among 80 cages from three Atlantic salmon grow-out farms in Maine, USA that were stocked with smolts from a single hatchery. Cage-level disease was broadly defined as one or more moribund fish testing positive for infectious salmon anaemia virus (ISAV) by RT-PCR and a second confirmatory test (IFAT, culture or genotype sequence). Spatio-temporal and cage-level risks were explored using logistic regression and survival analysis. Non-spatial risk factors associated with ISA, or shortened survival time to disease, included increased predation, trucking company choice for smolt transfers, a finely-sedimented benthic substrate, and smaller average size of smolts at stocking. Univariable analysis identified the time-dependent spatial factor 'adjacency to newly infected cages' to be predictive of new infection in neighbouring cages 11-12 weeks later. However, none of the spatial factors, or their lags retained relevance in multiple-variable models. The results suggest a diffuse distribution of virus exposure throughout infected sites, with host-susceptibility factors probably influencing disease manifestation in individual cages. The narrow focus of the current study may limit application of the findings to other sites and year-classes. However, these data support the relevance of husbandry efforts to optimize fish health in regions affected by ISAV.


Assuntos
Doenças dos Peixes/epidemiologia , Isavirus/isolamento & purificação , Infecções por Orthomyxoviridae/veterinária , Salmo salar/virologia , Animais , Doenças dos Peixes/virologia , Pesqueiros , Imunofluorescência , Isavirus/genética , Isavirus/imunologia , Modelos Logísticos , Maine/epidemiologia , Infecções por Orthomyxoviridae/epidemiologia , Estudos Retrospectivos , Reação em Cadeia da Polimerase Via Transcriptase Reversa/veterinária , Fatores de Risco , Análise de Sobrevida
9.
J Am Coll Cardiol ; 45(4): 493-5, 2005 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-15708692

RESUMO

OBJECTIVES: The purpose of this study was to determine the effects of transcatheter patent foramen ovale (PFO) closure on migraine frequency in patients with paradoxical cerebral embolism. BACKGROUND: The prevalence of migraine headache is higher in cryptogenic stroke patients with PFO than in the general population. Previous studies have suggested that closure of the PFO may reduce migrainous symptoms. METHODS: Between April 2001 and December 2003, 162 consecutive patients with paradoxical cerebral embolism underwent transcatheter PFO closure for prevention of recurrent cryptogenic stroke or transient ischemic attack. A one-year retrospective analysis of migraine symptoms before and after PFO closure was performed. RESULTS: Active migraine was present in 35% (57 of 162) of patients, and 68% (39 of 57) experienced migrainous aura; 50 patients were available for analysis at one year. Complete resolution of migraine symptoms occurred in 56% (28 of 50) of patients, and 14% (7 of 50) of patients reported a significant (>or=50%) reduction in migraine frequency. Patients reported an 80% reduction in the mean number of migraine episodes per month after PFO closure (6.8 +/- 9.6 before closure vs. 1.4 +/- 3.4 after closure, p < 0.001). Results were independent of completeness of PFO closure at one year. CONCLUSIONS: In patients with paradoxical cerebral embolism, migraine headaches are more frequent than in the general population, and transcatheter closure of the PFO results in complete resolution or marked reduction in frequency of migraine headache.


Assuntos
Cateterismo Cardíaco , Comunicação Interatrial/complicações , Comunicação Interatrial/cirurgia , Transtornos de Enxaqueca/etiologia , Transtornos de Enxaqueca/cirurgia , Embolia Paradoxal/complicações , Feminino , Seguimentos , Humanos , Embolia Intracraniana/complicações , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos
10.
J Neuroimaging ; 14(4): 342-9, 2004 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-15358955

RESUMO

BACKGROUND AND PURPOSE: Transcatheter closure of patent foramen ovale (PFO) can benefit from a less invasive diagnostic method than transesophageal echocardiography (TEE). Thirty-three gate power m-mode transcranial Doppler (pmTCD) was evaluated for its accuracy in diagnosis of PFO and utility in evaluating residual intracardiac right-to-left shunt (RLS) following transcatheter closure. METHODS: The sensitivity of pmTCD and single-gate TCD (sgTCD) to detect contrast bubble emboli through RLS was compared during transcatheter PFO closure. During 100 preclosure diagnostic evaluations and in 81 postclosure assessments, embolic tracks on pmTCD were counted following intravenous contrast injections and were graded using a 6-level logarithmic scale. The accuracy of TEE and pmTCD was separately compared to PFO anatomical findings during transcatheter closures. RESULTS: There were significantly more microemboli detectable on pmTCD (322 +/- 166; 95% confidence interval [CI], 388-257) than on sgTCD (186 +/- 109; 95% CI, 229-143; P < .001). McNemar change tests suggest that the diagnostic capabilities of pmTCD and TEE for detecting PFO are comparable and correspond to the anatomical findings determined during cardiac catheterization (P = .69 and .45, respectively). During 6-month postclosure evaluation (mean = 185 days), 66% of the patients demonstrated successful closure without significant RLS (ie, grades 0, I, or II), and 34% were found to have incomplete closure with significant RLS (ie, grades III, IV, or V). CONCLUSIONS: pmTCD provides greater sensitivity to contrast bubble emboli than does sgTCD. Among candidates for transcatheter closure, pmTCD provides an improved noninvasive method for diagnosing PFO and evaluating transcatheter closure.


Assuntos
Cateterismo Cardíaco , Comunicação Interatrial/diagnóstico por imagem , Comunicação Interatrial/terapia , Ultrassonografia Doppler Transcraniana/métodos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Análise de Variância , Embolia/diagnóstico por imagem , Embolia/etiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
11.
Ultrasound Med Biol ; 28(1): 49-57, 2002 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-11879952

RESUMO

Difficulties in location of transcranial ultrasound (US) windows and blood flow in cerebral vessels, and unambiguous detection of microemboli, have limited expansion of transcranial Doppler US. We developed a new transcranial Doppler modality, power M-mode Doppler (PMD), for addressing these issues. A 2-MHz digital Doppler (Spencer Technologies TCD100M) having 33 sample gates placed with 2-mm spacing was configured to display Doppler signal power, colored red and blue for directionality, in an M-mode format. The spectrogram from a user-selected depth was displayed simultaneously. This system was then explored on healthy subjects and patients presenting with varying cerebrovascular pathology. PMD facilitated window location and alignment of the US beam to view blood flow from multiple vessels simultaneously, without sound or spectral clues. Microemboli appeared as characteristic sloping high-power tracks in the PMD image. Power M-mode Doppler is a new paradigm facilitating vessel location, diagnosis, monitoring and microembolus detection.


Assuntos
Circulação Cerebrovascular/fisiologia , Embolia Intracraniana/diagnóstico por imagem , Embolia Intracraniana/fisiopatologia , Ultrassonografia Doppler Transcraniana/métodos , Humanos
12.
Lippincotts Prim Care Pract ; 4(4): 400-9, 2000.
Artigo em Inglês | MEDLINE | ID: mdl-11261116

RESUMO

Oncologic emergencies may occur in patients who have no prior diagnosis of malignancy as well as in patients who are known to have cancer. It is important for the primary care practitioner to consider an oncologic cause for symptoms or problems that may bring a patient into the office. These symptoms often are vague and could be indicative of numerous problems frequently associated with individuals who have cancer. A brief overview of the most common oncologic emergencies is given, along with differential diagnostic possibilities and management strategies.


Assuntos
Tamponamento Cardíaco/etiologia , Hipercalcemia/etiologia , Neoplasias/complicações , Compressão da Medula Espinal/etiologia , Síndrome da Veia Cava Superior/etiologia , Idoso , Tamponamento Cardíaco/diagnóstico , Tamponamento Cardíaco/epidemiologia , Tamponamento Cardíaco/terapia , Emergências , Feminino , Humanos , Hipercalcemia/diagnóstico , Hipercalcemia/epidemiologia , Hipercalcemia/terapia , Masculino , Pessoa de Meia-Idade , Neoplasias/terapia , Atenção Primária à Saúde , Compressão da Medula Espinal/diagnóstico , Compressão da Medula Espinal/epidemiologia , Compressão da Medula Espinal/terapia , Síndrome da Veia Cava Superior/diagnóstico , Síndrome da Veia Cava Superior/epidemiologia , Síndrome da Veia Cava Superior/terapia
13.
Ophthalmic Surg Lasers ; 30(9): 715-20, 1999.
Artigo em Inglês | MEDLINE | ID: mdl-10574492

RESUMO

PURPOSE: To report our experience with perfluoro-N-octane (PFO) in the surgical management of complicated retinal detachments due to proliferative diabetic retinopathy. METHODS: Retrospective review of 18 consecutive eyes of 18 patients with tractional or combined tractional and rhegmatogenous retinal detachments due to severe proliferative diabetic retinopathy managed by pars plana vitrectomy and the intraoperative use of PFO. Preoperative characteristics, intraoperative findings and procedures and postoperative results were recorded. RESULTS: The mean preoperative acuity was 2/200 (range, 20/25 to light perception). The mean final visual acuity was 4/200 (range, 20/20 to no light perception). With a mean follow-up of 6 months, there was an 89% anatomic reattachment rate at the last visit and visual acuity was stable or improved in 72% of eyes. CONCLUSIONS: In our experience, PFO is a helpful surgical adjunct in the anatomic reattachment of tractional or combined tractional and rhegmatogenous diabetic retinal detachments. Visual acuity was stabilized or improved in the majority of eyes.


Assuntos
Retinopatia Diabética/complicações , Fluorocarbonos/administração & dosagem , Descolamento Retiniano/cirurgia , Adulto , Retinopatia Diabética/diagnóstico , Humanos , Injeções , Período Intraoperatório , Fotocoagulação a Laser , Pessoa de Meia-Idade , Descolamento Retiniano/etiologia , Estudos Retrospectivos , Índice de Gravidade de Doença , Resultado do Tratamento , Acuidade Visual , Vitrectomia/métodos
14.
Ophthalmology ; 106(4): 782-9, 1999 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-10201603

RESUMO

OBJECTIVE: To assess the results of surgical excision of subfoveal choroidal neovascularization (CNV) in patients with age-related macular degeneration (AMD). DESIGN: Retrospective, interventional, noncomparative case series. PARTICIPANTS AND INTERVENTION: Sixty-four consecutive patients undergoing surgical removal of AMD-related subfoveal CNV were studied. The surgical method included a small retinotomy, subretinal tissue plasminogen activator (t-PA), perfluoro-n-octane, and air-fluid exchange. MAIN OUTCOME MEASURES: Final visual acuity was the main outcome measure; surgical complications and recurrence rates were also assessed. RESULTS: Preoperative visual acuity ranged from 20/100 to 1/200, with a mean of 20/400. Average follow-up was 19 months. The best acuity achieved after surgery ranged from 20/20 to hand motions, with a mean of 20/200. Final visual acuity ranged from 20/50 to light perception, with a mean of 20/400. Final acuity was improved 3 or more lines in 19 eyes (30%) (median, 5 lines), stable in 27 eyes (42%), and 3 or more lines worse in 18 eyes (28%) (median, 4 lines). Factors associated with greater visual improvement included poorer initial acuity, larger CNV size, and smaller subretinal hemorrhage. Analysis of groups similar to Macular Photocoagulation Study subgroups A through D showed an average improvement of 1 line for group C (visual acuity, 20/200 or worse; CNV larger than 2 disc areas). Other preoperative, intraoperative, and postoperative factors, including recurrence and retinal detachment, did not have a significant effect on final visual outcome. CONCLUSIONS: After surgical excision of AMD-related subfoveal CNV, vision improved or stabilized in the majority of patients. Surgery may be of greatest value for patients with poorer vision, larger subfoveal CNV, and minimal hemorrhage. Further evaluation of this technique should be accomplished via completion of a controlled, randomized multicenter study.


Assuntos
Neovascularização de Coroide/cirurgia , Fóvea Central , Degeneração Macular/complicações , Idoso , Idoso de 80 Anos ou mais , Neovascularização de Coroide/etiologia , Feminino , Fibrinolíticos/uso terapêutico , Angiofluoresceinografia , Fluorocarbonos/uso terapêutico , Humanos , Complicações Intraoperatórias , Masculino , Pessoa de Meia-Idade , Recidiva , Estudos Retrospectivos , Ativador de Plasminogênio Tecidual/uso terapêutico , Resultado do Tratamento , Acuidade Visual , Vitrectomia
15.
Curr Eye Res ; 16(9): 865-74, 1997 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-9288447

RESUMO

PURPOSE: Previous epidemiologic studies of uveitis have focused on predominantly Caucasian populations, and none have been based in the Southeast. We analyzed the epidemiology of uveitis among a referral population with a high percentage of African Americans in the United States. METHODS: We evaluated demographic data from 385 consecutive patients referred to the Duke Uveitis Clinic. RESULTS: Of the 385 patients, 120 (31%) were African American and 258 (67%) Caucasian; 237 (62%) were female and 148 (38%) male. The most common diagnoses among the 385 patients were idiopathic panuveitis (64 patients [17%]), idiopathic anterior uveitis (47 patients [12%]), pars planitis (46 patients [12%]), sarcoidosis (44 patients [11%]), and toxoplasmosis (39 patients [10%]). These diagnoses were also the most common among the 120 African American patients: 33 patients (28%) had idiopathic panuveitis, 30 (25%) had sarcoidosis, 10 (8%) had idiopathic anterior uveitis, 8 (7%) had toxoplasmosis, and 6 (5%) had pars planitis. Among the 258 Caucasian patients, the most common diagnoses were pars planitis (39 patients [15%]), idiopathic anterior uveitis (37 patients [14%]), toxoplasmosis (30 patients [12%]), idiopathic panuveitis (28 patients [11%]), and multifocal choroiditis and panuveitis (MCP) (17 patients [7%]). Categorizing diagnoses of all 385 patients by anatomic location, panuveitis was most frequent (148 patients [38%]), followed by anterior uveitis (97 patients [25%]), posterior uveitis (93 patients [24%]), and intermediate uveitis (47 patients [12%]). CONCLUSIONS: The higher frequency of sarcoidosis and idiopathic panuveitis than previously reported is related to our larger African American population base. The racial composition of the Southeast does not, however, account for differences such as our higher percentage of MCP; it is possible that other genetic or environmental factors play a role in this region.


Assuntos
População Negra , Uveíte/epidemiologia , Adolescente , Adulto , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Criança , Demografia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Sarcoidose/complicações , Sarcoidose/epidemiologia , Distribuição por Sexo , Sudeste dos Estados Unidos , Uveíte/classificação , Uveíte/etnologia , População Branca
16.
Ophthalmic Surg Lasers ; 28(8): 645-52, 1997 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-9268995

RESUMO

BACKGROUND AND OBJECTIVE: Subfoveal neovascular membranes are usually located either in the subsensory retinal space or below the retinal pigment epithelium (RPE). This article describes the clinical and histopathologic features of subfoveal membranes with both subretinal and sub-RPE components (combined membranes). PATIENTS AND METHODS: Six surgically excised subfoveal neovascular membranes from six patients were examined histopathologically. Preoperative and postoperative clinical information was obtained from each patient. RESULTS: Clinically, the combined membranes had no special characteristic features. The most common fluorescein angiographic finding postoperatively was a window defect of the RPE. Visual acuity improved in three patients and became worse in the other three patients. CONCLUSIONS: All patients with combined subfoveal neovascular membranes had age-related macular degeneration. In this disease, a single subfoveal membrane may extend into both the subretinal and the sub-RPE spaces. Patients may benefit from surgical removal of the membrane.


Assuntos
Degeneração Macular/complicações , Epitélio Pigmentado Ocular/patologia , Neovascularização Retiniana/patologia , Idoso , Idoso de 80 Anos ou mais , Membrana Basal/patologia , Feminino , Angiofluoresceinografia , Fóvea Central/patologia , Fundo de Olho , Humanos , Masculino , Epitélio Pigmentado Ocular/cirurgia , Neovascularização Retiniana/cirurgia , Estudos Retrospectivos
17.
Ophthalmic Genet ; 17(3): 115-8, 1996 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-8905852

RESUMO

Patients with germinal retinoblastoma (those with bilateral disease or positive family history) have a mutation which puts them at risk for developing new tumors. It is unclear whether the frequency of new tumor development is effected by the type of treatment employed. It may be hypothesized that external beam radiation "sterilizes' the whole retina, and thus decreases the risk of new and recurrent tumors. We reviewed our experience with 66 eyes in 47 patients over the past ten years. We did not find a significant difference in the incidence of new and recurrent retinoblastoma among eyes treated with external beam radiation versus focal modalities.


Assuntos
Neoplasias Oculares/terapia , Recidiva Local de Neoplasia/etiologia , Retinoblastoma/terapia , Braquiterapia , Pré-Escolar , Criocirurgia , Neoplasias Oculares/etiologia , Humanos , Incidência , Lactente , Fotocoagulação a Laser , Radioterapia de Alta Energia , Retinoblastoma/etiologia
18.
Echocardiography ; 13(5): 511-512, 1996 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-11442962
19.
Echocardiography ; 13(5): 519-528, 1996 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-11442964

RESUMO

Doppler detection of venous and arterial gas emboli has been recognized since 1968. The technology has been applied using 5-MHz ultrasound to study decompression sickness and monitor cardiopulmonary bypass and intracranial surgery. Since the advent of transcranial Doppler, which requires the use of lower ultrasonic carrier frequencies to penetrate the temporal bone, the detection of particulates moving in the bloodstream has been available. Using 2 MHz, microembolic signals have been detected in a variety of clinical situations, including cardiac conditions known to have high probabilities to produce embolic stroke. The basic features of a Doppler embolic signal have been clarified, and many investigators are applying the technology to determine the clinical significance of the detected emboli and their use in diagnosis and medical and surgical treatments. The basis for automatic sizing, counting, and characterizing the emboli is under development. The applications of Doppler detection of emboli will range from diagnosis and localization of embolic sources to improvement in surgical techniques and adjustments in medical treatments. (ECHOCARDIOGRAPHY, Volume 13, September 1996)

20.
Echocardiography ; 13(5): 551-554, 1996 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-11442968

RESUMO

BACKGROUND: Finding the pathological meaning of Doppler microembolic signals is important to developing the clinical applications of this new technology. METHODS: Two hundred eighty-four plaques, removed at carotid endarterectomy, were examined by the surgeon and pathologist for evidence of ulceration. The ipsilateral middle cerebral artery was monitored, with 2-MHz pulsed Doppler, preoperatively and during surgical mobilization of the carotid arteries. Associated Doppler embolic signals representing formed element emboli (FEE) were sought for 15-273 (mean 60) minutes. The embolization rate was calculated in FEE/hour. RESULTS: Preoperatively, 21% of patients demonstrated FEEs. During surgical mobilization of the carotid arteries, 51% demonstrated FEEs. A 79% prevalence of plaque ulceration was found. Analysis demonstrated 61% sensitivity and specificity, and an 86% positive predictive value. The positive predictive value increased progressively with higher FEE rates, up to 100% for patients with >60 FEE/hour. CONCLUSIONS: FEEs detected in the middle cerebral artery ipsilateral to carotid artery stenosis are diagnostic of plaque ulceration or luminal thrombus formation. Other embolic sources may be ruled out by monitoring the contralateral carotid artery system and the ipsilateral carotid arteries. There is no significant relationship between the number and prevalence of FEEs and the severity of stenosis or preoperative symptoms. Postoperative cerebral complications of stroke were associated with more FEEs than were postoperative transient ischemic attacks. (ECHOCARDIOGRAPHY, Volume 13, September 1996)

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