1.
Angew Chem Int Ed Engl
; 57(47): 15441-15444, 2018 11 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30277304
RESUMO
Viedma ripening is an emerging method for the solid-phase deracemization of mixtures of enantiomers. Up to now, the scope of the method has remained limited to molecules with a single stereocenter. We show here that this method can be extended to obtain a single enantiomer from a mixture of stereoisomers with two different stereocenters. In addition, we show that by using tailor-made chiral additives, the conversion time can be reduced by a factor of 100.