1.
Bioorg Med Chem Lett
; 22(15): 5031-4, 2012 Aug 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22749420
RESUMO
A series of 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives has been prepared and subsequently evaluated with regards to the inhibition of 5-LOX/COX. Structure optimization furnished derivatives with promising in vitro activity as dual 5-LOX/COX inhibitors with submicromolar IC(50) values for inhibition of 5-LOX and COX-1, respectively.