Sono-Maceration - a rapid and inexpensive method for the isolation of ursolic acid from Neolamarckia cadamba leaves.

This article records for the first time the isolation of Ursolic acid from the leaves of Neolamarckia cadamba (Roxb.) Bosser (Family: Rubiaceae) using ultrasonic waves. This bioactive triterpenic acid was isolated without its isomer, oleanolic acid, in a very convenient way with good yield. The structure was identified by means of one dimensional Nuclear Magnetic Resonance (NMR) spectroscopic techniques like 1H NMR, 13C NMR, distortionless enhancement by polarization transfer (DEPT) and two dimensional NMR spectroscopic method for example, heteronuclear single quantum coherence (HSQC). It was also assayed for antidiabetic and antioxidant potencies. About 71.5 mg of pure ursolic acid was isolated from 2.6 grams of ethyl acetate soluble fraction using sono-maceration as an extraction technique.

Synthesis of 2-oxoquinoline-3-carboxamide of ampicillin and amoxicillin as inhibitors of penicillin binding protein 1A of pseudomonas aeruginosa.

A series of ampicillin and amoxicillin derivatives were prepared by N-acylation with N1-substituted 1, 2-dihydro-2-oxoquinoline carboxylic acids by Schotten-Baumann procedure and evaluated as inhibitors of Pseudomonas aeruginosa using molecular docking study. Most of the derivatives showed remarkableactivity against Gram positive and Gram negative bacteria in vitro.