[Management of cutaneous toxicities induced by epidermal growth factor receptor inhibitors: a review]. / Prise en charge des toxicités cutanées des thérapies dirigées contre les récepteurs du facteur de croissance epidermique: revue de la littérature.

The epidermal growth factor receptor (EGFR) is overexpressed in many solid tumors. Its inactivation has an inhibitory effect on the growth and spread of the tumoral cells. It therefore represents an attractive target to treat different cancers. Several molecules have already been registered while others are still under evaluation. One of the common side effects of these therapies is the development of cutaneous toxicities, more precisely a cutaneous rash, sometimes major and distressing. The physiopathology of these cutaneous side effects is poorly understood. Moreover a correlation between the severity of the rash and the tumoral response has been demonstrated in some studies. If this link is confirmed, the rash could be used as a marker for the anti-tumoral activity. This review will summarize the clinical presentations and the current recommendations for the management of cutaneous toxicities induced by EGFR inhibitors.

Personal perspective: in search of an optimum cycling posture.

Correct cycling posture improves performance and may prevent injuries. This article addresses the most important variables that determine cycling posture of road racing cyclists. It focuses not only on 'posture height' but also on 'posture length', an aspect that has as yet received little attention. In order to help cyclists find their optimum posture, reliable anthropometric measuring is of utmost importance. The relevant measurements and the necessary measuring instruments are considered. Special attention is given to gender related posture aspects.