Vitamin D deficiency associated with risk of prediabetes among older adults: Data from the National Health and Nutrition Examination Survey (NHANES), 2007-2012.

AIM: To examine the association between vitamin D (25(OH)D) deficiency and risk of prediabetes in Americans 50+ years of age. MATERIALS AND METHODS: This was a cross-sectional analysis of NHANES (2007-2012) subjects aged 50+ years, free of kidney/liver diseases and diabetes. Prediabetes was defined as: HbA1c level 5.7%-6.4%, or fasting plasma glucose level 100-125 mg/dL, or Oral Glucose Tolerance Test result 140-199 mg/dL, with no laboratory value in the diabetic range. The comparison group had normal glucose tolerance (NGT) with no marker in the prediabetes/diabetes range. Total serum 25(OH)D levels were deficient at <50 nmol/L, insufficient 50-75 nmol/L, and sufficient >75 nmol/L. Logistic regression included strata, cluster and weight variables. Models were adjusted for body mass index (BMI), ethnicity, age and gender. RESULTS: The final sample was 2286 adults, predominantly White (80.4%) and female (56.6%), with a mean age of 62.3 years. Within the sample, 1387 had prediabetes (59.1%) and 899 were NGT (40.9%). Individuals classified within a lower serum vitamin D category were more likely to have prediabetes (p = 0.03). Those with 25(OH)D deficiency were more likely to have prediabetes compared to 25(OH)D sufficient individuals (crude OR = 1.48, 95% CI 1.15-1.91), and this association remained significant after adjustment for ethnicity, BMI, age and gender (aOR = 1.39, 95% CI 1.02-1.89). There was no effect modification by BMI, gender or ethnicity. CONCLUSIONS: Vitamin D status was associated with risk of prediabetes in this sample of Americans 50+ years of age. Future research should seek to understand the potential mechanistic relationship between vitamin D and prediabetes.

The association between an objective measure of physical activity and weight status in preschoolers.

OBJECTIVE: Our objective was to determine the association between physical activity and BMI among racially diverse low-income preschoolers. RESEARCH METHODS AND PROCEDURES: This was a cross-sectional study of 2- to 5-year-olds (n = 56) enrolled in Massachusetts Special Supplemental Nutrition Program for Women, Infants & Children (WIC). Physical activity was measured for 7 consecutive days with an accelerometer. Height and weight were obtained from WIC records, and BMI-for-age percentiles were calculated based on the Centers for Disease Control and Prevention's (CDC) 2000 Growth Charts. At-risk-for-overweight (BMI-for-age of > or = 85th to < 95th percentile) and overweight (BMI-for-age > or = 95th percentile) groups were combined and referred to as overweight. Final analysis inclusion criteria were: completion of 4.5 days of activity assessment and anthropometric data obtained within 90 and 120 days of the activity assessment for children ages 24 to 35.99 and 36 to 59.99 months, respectively. RESULTS: Overweight children had significantly lower mean daily very vigorous minutes (VVM) (2.6 mins vs. 4.6 mins, p < 0.05) and lower very active minutes (VAM) [i.e., sum of vigorous minutes (VM) and VVM] per day (22.9 mins vs. 32.1 mins, p < 0.05) than children who were not overweight. Daily VVM [odds ratio (OR) = 0.68; 95% confidence interval (CI), 0.49 to 0.96], VM (OR = 0.94; CI, 0.88 to 1.00), and VAM (OR = 0.94; 95% CI, 0.89 to 1.00) were all associated with significantly lower odds of being overweight. DISCUSSION: This study suggests that, in a diverse group of preschoolers, vigorous and very vigorous activity are associated with lower odds of overweight. However, these findings require corroboration in a diverse sample of preschoolers using a longitudinal design.