1.
Chem Commun (Camb)
; 51(90): 16259-62, 2015 Nov 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26400240
RESUMO
Short peptides featuring a tetrahydropyridazinedione (tpd) backbone tether exhibit reduced conformational flexibility external to the heterocyclic constraint. Analysis by NMR, molecular modeling and X-ray crystallography suggests both covalent and non-covalent stabilization of extended peptide conformations. An efficient solid-phase protocol was developed for the synthesis of a new class of ß-strand mimics based on oligomeric tpd subunits.