[HPLC of oligodeoxyribonucleoside phosphorothioates ]. / V'EAZKH oligodesokciribonukleozidtiofosfatov.

Conditions are described for the separation of synthetic oligodeoxyribonucleoside phosphorothioates by HPLC using a SCOUT WP PEI weak anion exchanger and for the separation of oligodeoxyribonucleotides with mixed phosphate and phosphorothioate internucleotide bonds on a Partisphere C18 support in ion-pair conditions. The influence of the nucleoside composition and the number of phosphorothioate bonds on the retention time was studied.