RESUMO
The effect of continuous versus interrupted high-dose aspirin (ASA) for 14 days was evaluated in a randomized double-blind study in 8 rheumatoid arthritis patients. Acute gastric mucosal injury was measured by serial gastroscopy and gastric biopsy. Significant gross mucosal damage was seen in all patients following 3 days of ASA (P less than 0.01) and persisted without significant change in severity to the end of the study. Histologic gastritis in areas free of hemorrhages and erosions was not increased significantly by ASA. In spite of gross mucosal injury, symptoms occurred infrequently. Serum pepsinogen I, but not serum gastrin, increased significantly following 3 days of ASA, and the elevation persisted to the end of the study. The extent of mucosal injury at 14 days was not significantly different in those receiving ASA continuously from those on an interrupted schedule. Thus, gastric mucosal adaptation to ASA in man was not demonstrated.
Assuntos
Aspirina/administração & dosagem , Mucosa Gástrica/efeitos dos fármacos , Artrite Reumatoide/tratamento farmacológico , Ensaios Clínicos como Assunto , Relação Dose-Resposta a Droga , Avaliação de Medicamentos , Mucosa Gástrica/patologia , Gastrinas/sangue , Gastrite/induzido quimicamente , Gastrite/patologia , Gastroscopia , Humanos , Masculino , Pessoa de Meia-Idade , Pepsinogênios/sangue , Antro Pilórico/patologia , Fatores de TempoRESUMO
The effect of metoclopramide, a stimulant of gastric motility, on gastric emptying was tested in 6 patients with chronic gastric retention after vagotomy and gastric resection, unexplained by mechanical obstruction or stomal ulceration. Gastric emptying was measured using a gamma camera technique and a solid meal labeled with 99mtechnetium-labeled diethylenetriaminepentaacetic acid. Metoclopramide produced a 2.6-fold increase in gastric emptying in the first 90 min after eating the meal, compared to placebo (P less than 0.01). Metoclopramide did not alter gastric emptying in 8 normal volunteers. These data indicate that metoclopramide may be useful in treatment of patients with chronically impaired gastric emptying after gastric surgery.
Assuntos
Metoclopramida/uso terapêutico , Síndromes Pós-Gastrectomia/tratamento farmacológico , Gastropatias/tratamento farmacológico , Adulto , Humanos , Masculino , Pessoa de Meia-Idade , Placebos , Cintilografia , VagotomiaRESUMO
A case of Crohn's disease which presented as a gastrocolic fistula is described. Clinical, laboratory and pathological descriptions are included. The incidence and various etiologies of gastrocolic fistulas are discussed.
