Assuntos
Alopecia/cirurgia , Cicatriz/cirurgia , Cabelo/transplante , Adulto , Idoso , Alopecia/diagnóstico por imagem , Alopecia/patologia , Cicatriz/diagnóstico por imagem , Cicatriz/patologia , Dermoscopia , Feminino , Seguimentos , Cabelo/diagnóstico por imagem , Humanos , Pessoa de Meia-Idade , Satisfação do Paciente , Estudos Retrospectivos , Pele/diagnóstico por imagem , Pele/patologia , Fatores de Tempo , Resultado do TratamentoRESUMO
BACKGROUND: Surgical excision is the preferred method of eradicating Bowen´s disease (BD). Photodynamic therapy (PDT) has been successfully used for treatment of actinic keratosis, basal cell carcinoma, and BD. OBJECTIVE: Our aim was to evaluate the efficacy and tolerability of PDT for treatment of extensive BD. METHOD: Eighteen patients with 23 biopsy-proven BD lesions were treated with PDT. We defined as extensive those lesions large than 3 cm. Methyl aminolevulinate cream was applied for 3 h before illumination with an light emitting diode light source at a wavelength of 630 nm (energy density of 37 J/cm²). Treatment was repeated 1 week later. RESULTS: After 12 weeks of treatment, 22 of 23 BD lesions (90%) showed complete clinical response. Only three lesions recurred after a follow-up period of 12 months. Cosmetic outcome at 12 months was good or excellent in 94% of patients. CONCLUSION: Methyl aminolevulinate PDT is an effective treatment option for extensive BD with excellent cosmesis.
