[The use of nimodipine in the acute period of a cerebral infarct]. / O primenenii nimodipina v ostrom periode infarkta mozga.

Before and after intravenous administration of 1-1.5 mg nimotop 18 patients with acute brain infarction underwent EEG, integral body rheography, computed tomography and measurement of regional volumetric cerebral circulation (RVCC). Nimotop appeared to increase RVCC in the infarction zone, especially in low initial RVCC levels. The drug induced a shift to EEG normalization and a hypotensive effect, cerebral hemodynamics remaining without changes. Nimodipine-type calcium antagonists favourably affect brain perfusion and bioelectric activity which is promising for application in acute cerebral infarction.

[Effect of calcium antagonists of the verapamil type on regional cerebral blood flow and bioelectric activity of the brain in patients with cerebral infarction]. / Deistvie antagonistov kal'tsiia tipa verapamila na regionarnyi ob"emnyi mozgovoi krovotok i bioélektricheskuiu aktivnost' golovnogo mozga u bol'nykh tserebral'nym infarktom.

The authors have studied the regional volume cerebral blood flow (RVCBF) in 25 patients with acute cerebral infarction before and after the intravenous administration of 5-7.5 mg of isoptin and carried out quantitative frequency analysis of the EEG in 20 patients prior to and following the administration of 5 mg of finoptin. It has been revealed that isoptin augments the RVCBF in the infarcted zone, particularly when patients with extensive infarction, edema and atrophy of the cerebral tissue (according to findings of computer-aided tomography) have low baseline levels of the RVCF and somewhat decreases the blood flow in intact zones. The administration of finoptin tended to normalize the EEG, particularly in the infarcted area in patients with a severe clinical picture of infarction. Calcium antagonists of the verapamil type exert a favourable effect on perfusion and bioelectrical activity of the brain; as a result their use is indicated in the patients with acute cerebral infarction.

[Pharmacodynamic action of cavinton on regional volume blood flow, central hemodynamics and the bioelectric activity of the brain in the acute stage of a cerebral infarct]. / Farmakologicheskoe deistvie kavintona na regionarnyi ob''emnyi mozgovoi krovotok, tsentral'nuiu gemodinamiku i bioélektricheskuiu aktivnost' golovnogo mozga v ostroi stadii tserebral'nogo infarkta.

Forty-two patients with acute cerebral infarction were studied for the regional volumetric cerebral blood flow (rVCBF) and central hemodynamics (by integral rheography of the body) before and after the intravenous administration of 10 or 20 mg of cavinton (vinpocetine). It was found that in the absence of changes in the central hemodynamics an increase in the cerebral blood flow was the predominant characteristic, but parodoxical reactions were occasionally observed in the acute period of an extensive hemispherical infarct. The findings of quantitative frequency analysis of the EEG conducted in 40 patients correlated with the results of the study of the blood flow and indicated a more favourable prognosis in brain stem infarction or mild cortical infarction. Treatment of extensive cortical infarction was associated with cases of parodoxical deterioration of brain function which should be taken into account in prescribing cavinton to patients during the acute stage of cerebral infarction.

[Combined quantitative analysis of electro- and rheoencephalograms at different ages and features of their individual indices with use of vasoactive drugs]. / Kombinirovannyi kolichestvennyi analiz élektro- i reoéntsefalogramm v razlichnykh vozrastakh i osobennosti ikh otdel'nykh pokazatelei pri primenenii vazoaktivnykh veshchestv

The polygraphic studies with the calculation of the complex of the EEG and REG quantitative parameters which were conducted in 20 individuals of young age and 20 adult individuals, displayed that there was an increase of the vascular tone and a decrease of the brain pulse blood-content which were observed not rarely with the EEG irritation at the same time in the mature age. Papaverine and euphilline action revealed dependence on the initial tone of the brain vessels and expressiveness of the general hemodynamic shifts.