[An analysis of the lymphocytes with anomalous nuclei in the peripheral blood of rats subjected to gamma irradiation]. / Analiz limfotsitov s anomal'nymi iadrami v perifericheskoi krovi krys, podvergnutykh gamma-oblucheniiu.

The share of lymphocytes with abnormal nuclei in the peripheral rat blood was found to increase during the first 24 h following irradiation with doses LD0, LD50, and LD100. With LD50 the index under study significantly varied in survived, died and control animals. It is suggested that the occurrence of abnormal nuclei in the peripheral rat blood is the result of the two processes, namely, the mitotic division and apoptotic death of cells.

[A comparative study of the micronucleus test and chromosome aberrations in PHA-stimulated human lymphocytes]. / Sravnitel'noe issledovanie mikroiadernogo testa i khromosomnykh aberratsii v FGA-stimulirovannykh limfotsitakh cheloveka.

A dose dependence of the number of cells with chromosome aberrations was studied in PHA-stimulated donor's peripheral blood lymphocytes irradiated in vitro with doses of 10-400 cGy. In studying the number of chromosome aberrations and percentage of cells with micronuclei in parallel cultures no correlation was found between these indices within the groups exposed to a similar radiation dose.

[Activity of granulocyte proteinases and level of acid-stable proteinase inhibitors in the bronchial secretions of children with bronchopathies of different etiology]. / Aktivnost' proteinaz granulotsitov i uroven' kislotostabil'nykh ingibitorov proteinaz v bronkhial'nom sekrete detei s bronkhopatiiami razlichnoi étiologii.

Activities of elastase- and trypsin-like proteinases from granulocytes as well as content of their acid-stable inhibitors were studied in 80 samples of the bronchial secretory products obtained from 34 children from 4 to 15 years old suffering from various forms of bronchopulmonary pathology/primary chronic pneumonia, Cartagener's syndrom, mucoviscidosis, pulmonary malformations. Normal bronchial secretory products were characterized by high content of the acid-stable inhibitors as well as by absence of the granulocytic proteinases activity. Development of inflammatory impairments in bronchi was accompanied by 2-3-fold decrease in content of the inhibitors with simultaneous increase in the enzymatic activity. The data obtained suggest that the relationship between activity of granulocytic proteinases and content of acid-stable inhibitors in bronchial secretory products might be considered as an important index of inflammatory processes in bronchi. De novo synthesis of acid-stable inhibitors in lungs appears to be decreased in the course of development of inflammation.