Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
West Afr J Med ; 32(4): 243-7, 2013.
Artigo em Inglês, Francês | MEDLINE | ID: mdl-24488276

RESUMO

Changing lifestyle, driven by socio-economic trends, is changing the cardiovascular risk and disease profile in developing countries. We studied the cardiovascular risk factors of Federal Medical Centre, Umuahia hospital staff between 40 and 60 years. 297 members of hospital staff were consecutively recruited in October 2010. Data obtained include blood pressure, height and weight, body mass index (BMI), fasting blood sugar, serum cholesterol (total and differential) and serum triglyceride. The data were analysed using the SPSS package (version 10). The following prevalence levels were found: hypertension 37.5%, obesity 40.8%, diabetes mellitus 5.7%, hypercholesterolemia 18.1% and metabolic syndrome 24.7%. LDL, low HDL and elevated TG were elevated in 26.8%, 41.9% and 9.7% respectively. Only 2% had very low risk for cardiovascular disease.


Assuntos
Doenças Cardiovasculares/etiologia , Dislipidemias/epidemiologia , Transtornos do Metabolismo de Glucose/epidemiologia , Hipertensão/epidemiologia , Corpo Clínico Hospitalar , Obesidade/epidemiologia , Adulto , Doenças Cardiovasculares/diagnóstico , Doenças Cardiovasculares/metabolismo , Estudos Transversais , Dislipidemias/complicações , Dislipidemias/diagnóstico , Feminino , Transtornos do Metabolismo de Glucose/complicações , Transtornos do Metabolismo de Glucose/diagnóstico , Humanos , Hipertensão/complicações , Hipertensão/diagnóstico , Masculino , Pessoa de Meia-Idade , Nigéria , Obesidade/complicações , Obesidade/diagnóstico , Prevalência , Fatores de Risco
2.
Eur J Biochem ; 267(2): 305-20, 2000 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-10632700

RESUMO

This study describes the molecular makeup of the cell-wall lipopolysaccharides (LPSs) (O-chain polysaccharide-->core oligosaccharide-->lipid A) from five Helicobacter pylori strains: H. pylori 26695 and J99, the complete genome sequences of which have been published, the established mouse model Sydney strain (SS1), and the symptomatic strains P466 and UA915. All chemical and serological experiments were performed on the intact LPSs. H. pylori 26695 and SS1 possessed either a low-Mr semi-rough-form LPS carrying mostly a single Ley type-2 blood-group determinant in the O-chain region covalently attached to the core oligosaccharide or a high-Mr smooth-form LPS, as did strain J99, with an elongated partially fucosylated type-2 N-acetyllactosamine (polyLacNAc) O-chain polymer, terminated mainly by a Lex blood-group determinant, connected to the core oligosaccharide. In the midst of semi-rough-form LPS glycoforms, H. pylori 26695 and SS1 also expressed in the O-chain region a difucosylated antigen, alpha-L-Fucp(1-3)-alpha-L-Fucp(1-4)-beta-D-GlcpNAc, and the cancer-cell-related type-1 or type-2 linear B-blood-group antigen, alpha-D-Galp(1-3)-beta-D-Galp(1-3 or 4)-beta-D-GlcpNAc. The LPS of H. pylori strain P466 carried the cancer-associated type-2 sialyl Lex blood-group antigen, and the LPS from strain UA915 expressed a type-1 Leb blood-group unit. These findings should aid investigations that focus on identifying and characterizing genes responsible for LPS biosynthesis in genomic strains 26695 and J99, and in understanding the role of H. pylori LPS in animal model studies. The LPSs from the H. pylori strains studied to date were grouped into specific glycotype families.


Assuntos
Helicobacter pylori/química , Antígenos CD15/química , Lipopolissacarídeos/química , Lipopolissacarídeos/classificação , Animais , Sequência de Carboidratos , Helicobacter pylori/classificação , Helicobacter pylori/genética , Helicobacter pylori/imunologia , Antígenos do Grupo Sanguíneo de Lewis/química , Lipopolissacarídeos/análise , Espectroscopia de Ressonância Magnética , Camundongos/microbiologia , Dados de Sequência Molecular , Oligossacarídeos/química , Especificidade da Espécie
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...