1.
Org Lett
; 2(19): 2921-2, 2000 Sep 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10986072
RESUMO
A short formal synthesis of squalamine is described, utilizing the biotransformation product 2, which is available in one step from commercially available 3-keto-23,24-bisnorchol-4-en-22-ol (1). Regioselective C-22 oxidation and C-24 sulfation of the corresponding alcohols in the presence of a free C-7 alcohol make for an efficient preparation of squalamine intermediate 11.