Focal convulsions associated with subclinical measles infection.

A patient with focal convulsions of sudden onset had cerebrospinal pleocytosis and electroencephalographic evidence of a focal lesion in the right hemisphere. Except for fever, there was no clinical evidence of a viral infection. Measles antibodies were detected in the serum and CSF. The CSF abnormalities resolved, and the patient has been well for 4 years. This case is unusual because of the focal CNS involvement and the lack of any other clinical features of measles infection.

Neonatal polycystic encephalomalacia: four new cases and review of the literature.

Four patients with pathologically documented polycystic cavitation of the brain had an acute illness characterised by stupor, seizures, CSF erythrocytic and monocytic pleocytosis, increased CSF protein, and diminished CSF glucose. The acute phase was followed by chronic decerebation, disappearance of the CSF abnormalities, and radiological evidence of polycystic cavitation of the brain. In one patient Herpes simplex was isolated from a cutaneous vesicle. The CSF abnormalities in the disorder have received scant attention, and have not previously been correlated with the acute and chronic stages. Clearly some cases are associated with Herpes simplex virus. The clinical profile should now be sufficiently distinctive to permit future identification of the aetiology in more neonates.