The significance of selected epidemiologico-clinical factors in the prevalence of the Helicobacter pylori infection in young males.

A serological diagnosis (ELISA test) was carried out of infections by Helicobacter pylori in 1200 young males (recruits in the Polish Army) and the influence of selected epidemiologico-clinical factors (civil status, place of residence, profession, economical conditions, tobacco smoking, consumption of alcohol, diseases of the parodontonium, nutritional habits) on the prevalence of the infection was studied. Specific antibodies were detected in 228 (19%) of the persons tested. Of the eight factors analyzed, only three parodontium diseases, tobacco smoking and place of residence (of decreasing importance in that order), had a statistically significant relationship to infection by Helicobacter pylori in young males.

Significance of the 14C-urea breath test in the determination of the location infected by Helicobacter pylori in the alimentary canal.

118 patients with chronic gastritis were the subject of the tests; they were divided into two groups on the basis of a bacteriological (culture) diagnosis of the infections by Helicobacter pylori: group I-patients with the infection present only in the stomach; group II-patients with the infection synchronically occurring in the mouth and the stomach. Both groups underwent the 14C-urea breath test to detect the Helicobacter pylori infection. In general, for the patients of group I the radioactivity of the samples of blown air showed a single maximum after ca 15-25 min. For patients of group II two maxima were obtained, the first after ca 5 min and the second after ca 15-25 min. Our investigations indicate that the 14C-urea breath test can not only be used to detect patients infected by Helicobacter pylori but also to establish the location (mouth, stomach) in the alimentary canal of the infection by that bacterium.

[Comparison of thrombosis rate after laparoscopic and conventional interventions with the I(125) fibrinogen test]. / Vergleich der Thromboserate nach laparoskopischen und konventionellen Eingriffen mittels des J125-Fibrinogen-Tests.

The purpose of the present work was to compare the frequency of thrombosis in patients after laparoscopic and conventional operations. The diagnosis of thrombotic complications of the veins of the legs was determined by means of the I125 fibrinogen test. This isotopic test was chosen because it enables the early diagnosis of a thrombosis of the venous sinus of the calf at a stage at which no clinical symptoms have yet appeared. It was shown that in the group of patients submitted to laparoscopic intervention only 19 (18.8%) developed thrombotic complications out of the 101 patients, whereas in the group of conventionally operated patients 42 cases (45.7%) occurred in the 92 patients. Moreover, there was a statistically significant difference in the incidence of thrombotic complications in patients after laparoscopic cholecystectomy in comparison with the traditional operative method, with 14 cases (23.3%) out of 60 patients versus 35 (62.5%) out of 56 patients, respectively.

[The effect of Helicobacter pylori infection and duodenogastric reflux on the histology of gastric mucosa in peptic ulcers]. / Wplyw zakazenia Helicobacter pylori i refluksu dwunastniczo-zoladkowego na obraz histologiczny blony sluzowej zoladka w chorobie wrzodowej.

In a group of 96 patients with peptic ulcer (36 patients with ulcer of the stomach, 60 patients with ulcer of the duodenum) we analysed the alterations of the mucosa of the stomach associated with the ulcer. A significantly frequent occurrence was shown of the athropic gastritis and of the dysplasia in patients with ulcer of the stomach in comparison with the group of patients with ulcer of the stomach in the comparison with the group of the patients with ulcer of the duodenum. Among the patients analysed we also appraised the alterations on the picture of the stomach mucosa of the Helicobacter pylori infection, of the duodeno-gastric reflux as well as of the concentration of the bile acids and of lysolecithin contained in the gastric juice in the ulcerous disease of the stomach and of the duodenum. The presence of the Helicobacter pylori infection was identified bacteriologically, the duodeno-gastric reflux was diagnosed with the radionucleide method and the concentration of the bile acids and lysolecithin in gastric juice was determined chromatographically. It was confirmed that the Helicobacter pylori infection as well as the bile acids and the lysolecithin the concentration of which in the gastric juice in patients with an ulcer in the stomach were significantly higher in comparison with patients with and the ulcer in the duodenum, were a decisive factor for more exacerbated histological alterations of the mucosa of the stomach in case of ulcer of the stomach.

[Coexistence of infection of the oral cavity and stomach and duodenal mucosa with Helicobacter pylori in patients with ulcer and chronic gastritis]. / Koexistenz der Infektion der Mundhöhle sowie der Magen- und Duodenalschleimhaut mit Helicobacter pylori bei Patienten mit Ulkuskrankheit und chronischer Gastritis.

In a group of 260 patients with a peptic ulcer of the stomach or the duodenum and/or chronic gastritis, bacteriological tests were conducted aiming at the detection of Helicobacter pylori in the mucosa of the stomach and the duodenum and in the gingival pockets. The presence of the infection of the mucosa of the stomach and/or of the duodenum was confirmed in 197 patients (75.8%). In this group of patients the bacteria occurred simultaneously in the oral cavity in 77 (39.1%) patients. It was found that the frequency of coexistence of Helicobacter pylori infection in the gingival pockets with an infected gastric or duodenal ulcer was not statistically significant. However, there was a statistically significant correlation between the frequency of Helicobacter pylori infection in the oral cavity (83.3%) and the simultaneous occurrence of extensive infection of the gastric mucosa.

[Duodenogastric reflux and Helicobacter pylori infection in chronic gastritis--evaluation of risk factor significance and risk factor interactions]. / Refluks dwunastniczo-zoladkowy i zakazenie Helicobacter pylori w przewleklym zapaleniu zoladka--ocena znaczenia czynników i wystepujacych miedzy nimi interakcji.

Among 184 sick persons with chronic gastritis proved histologicaly, frequency of appearance of duodenal gastric reflux was estimated scintigraphically, and frequency of appearance of IgG against Helicobacter pylori by serologic test (ELISA and IFP). Reflux was proved in 70 (38%) cases, whereas in 152 (82.6%) specific IgG was found. Using GLM program in the statistic analysis it was found that impact of each of these factors on inflammatory changed gastric mucous membrane is different. The weakest impact of reflex was on appearance of GChA in stomach, impact was 1.9 times higher on appearance of GChpA, GChSimp.--6.4 times higher and of GChSup. as high as 23.9 times. Whereas the weakest impact of Helicobacter pylori was on appearance of GChSimp. in stomach, in appearance of GChSup. the impact was 1.4 times higher, GChpA--1.9 times higher, while GChA 2.1 times higher. Taking into consideration interaction between reflux and infection it was proved that bacterial factor (Helicobacter pylori) acts on gastric mucous membrane (except chronic superficial inflammation) from 2.3 to 30.1(!) times higher (depending on form of chronic inflammation) than duodenal-gastric reflux.