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2.
Reg Anesth Pain Med ; 26(2): 100-4, 2001.
Artigo em Inglês | MEDLINE | ID: mdl-11251131

RESUMO

BACKGROUND AND OBJECTIVES: To quantify the motor threshold current of a needle following elicitation of paresthesia during axillary brachial plexus block (ABPB). METHODS: This is a prospective, observational study of ABPB in 72 patients. Having elicited paresthesia, the minimum current required to produce a motor response was noted. The development and success of the block were subsequently followed. RESULTS: Nineteen blocks were excluded (18 because of arterial puncture and 1 blocked needle). Of the remaining 53 blocks, 41 (77%) produced a motor response at 0.5 mA or less. The median current was 0.17 mA (range, 0.03 to 3.3 mA). The site of initial paresthesia and subsequent motor response were related in 43 (81%) of cases. CONCLUSIONS: A needle position causing paresthesia produced a motor response at 0.5 mA or less in 77% of cases studied. This current may, therefore, be a reasonable threshold to aim for when performing an ABPB.


Assuntos
Axila , Plexo Braquial , Bloqueio Nervoso , Parestesia , Anestésicos Locais , Braço , Estimulação Elétrica , Potencial Evocado Motor , Humanos , Lidocaína , Pessoa de Meia-Idade , Músculo Esquelético/inervação , Bloqueio Nervoso/métodos , Parestesia/etiologia , Estudos Prospectivos , Limiar Sensorial
3.
J Med Chem ; 14(12): 1193-7, 1971 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-5116233

RESUMO

PIP: The synthesis of a series of triphenylethlenes with CF(3) groups placed directly on the ethylene carbon is described, and the postcoital and uterotropic activities of these 1-trifluoromethyl-1,2,2-triphenylethylenes are determined. The parent compound and 3 substituted analogs were prepared by the stepwise replacement of the vinylic F atoms of hexafluoropropene with aryl groups from ArLi reagents. The postcoital antifertility and uterotrophic activities in the rat were determined by treating rats with induced precocious puberty with the synthesized compounds for 6 days after mating occurred. The most potent compound of this series was trans-p-methyoxy-alpha-phenyl-alpha'-(trifluoromethyl) stilbene.^ieng


Assuntos
Anticoncepcionais Orais/síntese química , Etilenos/síntese química , Administração Oral , Animais , Compostos de Benzil/administração & dosagem , Compostos de Benzil/síntese química , Compostos de Benzil/farmacologia , Anticoncepcionais Orais/administração & dosagem , Anticoncepcionais Orais/farmacologia , Anticoncepcionais Pós-Coito/síntese química , Etilenos/administração & dosagem , Etilenos/farmacologia , Feminino , Fertilidade/efeitos dos fármacos , Flúor , Espectroscopia de Ressonância Magnética , Masculino , Ratos , Ratos Endogâmicos , Relação Estrutura-Atividade , Estirenos/administração & dosagem , Estirenos/síntese química , Estirenos/farmacologia , Fatores de Tempo , Útero/efeitos dos fármacos
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