RESUMO
The interpretation of specific IgE test results in patients with suspected food allergies is not always straightforward. In fact, specific IgE test results for food allergens can provide physicians with more questions than answers. Based on the description of two patient cases, we discuss the interpretation of specific IgE test results for food allergens; the description includes the diagnostic process, cross-reactivity and component-resolved diagnostics.
Assuntos
Hipersensibilidade Alimentar/diagnóstico , Imunoglobulina E/imunologia , Alérgenos/imunologia , Criança , Reações Cruzadas/imunologia , Feminino , Hipersensibilidade Alimentar/imunologia , Humanos , Masculino , Malus/imunologia , Hipersensibilidade a Amendoim/imunologiaRESUMO
A 45-year-old woman was diagnosed with carotenaemia due to excessive intake of beta-carotene in a vitamin drink.
Assuntos
Suplementos Nutricionais/efeitos adversos , Pigmentação da Pele/efeitos dos fármacos , beta Caroteno/administração & dosagem , beta Caroteno/sangue , Feminino , Mãos , Humanos , Pessoa de Meia-IdadeRESUMO
BACKGROUND: About 25% of greenhouse flower and/or ornamental plant growers sensitised to workplace flowers or moulds have occupational asthma, a disease that is suffered by 8% of the growers who cultivate these crops. AIM: To document a case of occupational asthma due to IgE mediated allergy to the flower Molucella laevis. METHODS: and RESULTS: There was a history of work related seasonal asthmatic and rhinoconjunctivitis symptoms in a Molucella laevis grower. Bronchial obstruction following exposure to Molucella laevis was documented by a fall in FEV(1) from 89% to 73% of predicted during seasonal exposure to Molucella laevis. Daily PEF measurements showed a fall from 500 to 250 l/min during this period following withdrawal of inhaled steroids. Bronchial reactivity to inhaled methacholine was increased (PC(20) 1.45 mg/ml). Confirmation of sensitisation to Molucella laevis flower pollen extract was done using an SPT and by demonstration of Molucella laevis specific serum IgE (18 IU/ml; class 4). Specific inhalation challenge with Molucella laevis extract provoked an early and late asthmatic reaction (EAR and LAR) with a fall in FEV(1) compared with control day of 40% and 53% respectively, with associated 5.1-fold increase in absolute sputum eosinophil cell counts and 2.9-fold increase in neutrophil cell counts.
Assuntos
Alérgenos/efeitos adversos , Asma/etiologia , Imunoglobulina E/efeitos adversos , Doenças Profissionais/etiologia , Exposição Ocupacional , Pólen/efeitos adversos , Poluentes Ocupacionais do Ar/efeitos adversos , Poluentes Ocupacionais do Ar/análise , Albuterol/uso terapêutico , Asma/tratamento farmacológico , Broncodilatadores/uso terapêutico , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do TratamentoAssuntos
Anafilaxia/etiologia , Hipersensibilidade/complicações , Hipersensibilidade/etiologia , Poaceae/efeitos adversos , Pele/imunologia , Adulto , Dermatite de Contato/complicações , Dermatite de Contato/etiologia , Humanos , Hipersensibilidade/imunologia , Masculino , Poaceae/imunologia , Urticária/etiologiaRESUMO
Management of respiratory failure in acute respiratory distress syndrome (ARDS) typically requires ventilatory assistance. If traditional approaches to mechanical ventilation and adjunctive measures fail to succeed in achieving adequate oxygenation, alternative measures should be considered. We describe an ARDS patient with respiratory failure caused by a severe Chlamydiaceae species community-acquired pneumonia (CAP). Aerosolized prostacyclin (PGI(2)) treatment was successfully instituted for refractory hypoxemia.
